Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Noah Post"'
Autor:
Colby S. Shemesh, Rosie Z. Yu, Mark S. Warren, Michael Liu, Mirza Jahic, Brandon Nichols, Noah Post, Song Lin, Daniel A. Norris, Eunju Hurh, Jane Huang, Tanya Watanabe, Scott P. Henry, Yanfeng Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 34-47 (2017)
Antisense oligonucleotides are metabolized by nucleases and drug interactions with small drug molecules at either the cytochrome P450 (CYP) enzyme or transporter levels have not been observed to date. Herein, a comprehensive in vitro assessment of th
Externí odkaz:
https://doaj.org/article/e207d7ae85c046919a7c54818f631e90
Autor:
Rosie Z Yu, Mark J Graham, Noah Post, Stan Riney, Thomas Zanardi, Shannon Hall, Jennifer Burkey, Colby S Shemesh, Thazha P Prakash, Punit P Seth, Eric E Swayze, Richard S Geary, Yanfeng Wang, Scott Henry
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotides (ASOs) have greatly improved potency via receptor-mediated uptake. In the present study, the in vivo pharmacology of a 2′-O-(2-methoxyethyl)-modified ASO conjugated
Externí odkaz:
https://doaj.org/article/2b26807b841244429f7ffc38c01b9c47
Autor:
Colby S Shemesh, Rosie Z Yu, Hans J Gaus, Sarah Greenlee, Noah Post, Karsten Schmidt, Michael T Migawa, Punit P Seth, Thomas A Zanardi, Thazha P Prakash, Eric E Swayze, Scott P Henry, Yanfeng Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Triantennary N-acetyl galactosamine (GalNAc3) is a high-affinity ligand for hepatocyte-specific asialoglycoprotein receptors. Conjugation with GalNAc3 via a trishexylamino (THA)-C6 cluster significantly enhances antisense oligonucleotide (ASO) potenc
Externí odkaz:
https://doaj.org/article/1de8c3f8738147bdba5db5c61c7a342f
Autor:
Surinder Kaur, Stephen C Alley, Matt Szapacs, Amanda Wilson, Eugene Ciccimaro, Dian Su, Neil Henderson, Linzhi Chen, Fabio Garofolo, Shawna Hengel, Wenying Jian, John F Kellie, Anita Lee, John Mehl, Joe Palandra, Haibo Qiu, Natasha Savoie, Diaa Shakleya, Ludovicus Staelens, Hiroshi Sugimoto, Giane Sumner, Jan Welink, Robert Wheller, Y-J Xue, Jianing Zeng, Jinhui Zhang, Huiyu Zhou, Jian Wang, Scott Summerfield, Olga Kavetska, Lieve Dillen, Ragu Ramanathan, Mike Baratta, Arindam Dasgupta, Anna Edmison, Luca Ferrari, Sally Fischer, Daniela Fraier, Sam Haidar, Kathrin Heermeier, Christopher James, Allena Ji, Lina Luo, Gustavo Mendes Lima Santos, Noah Post, Anton I Rosenbaum, Sune Sporring, Sekhar Surapaneni, Stephen Vinter, Katty Wan, Eric Woolf, Seongeun (Julia) Cho, Elham Kossary, Sandra Prior, Mohsen Rajabi Abhari, Catherine Soo, Yow-Ming Wang, Abbas Bandukwala, Elana Cherry, Isabelle Cludts, Soma Ghosh, Shirley Hopper, Akiko Ishii-Watabe, Susan Kirshner, Kevin Maher, Kimberly Maxfield, Joao Pedras-Vasconcelos, Yoshiro Saito, Dean Smith, Therese Solstad, Daniela Verthelyi, Meenu Wadhwa, Leslie Wagner, Günter Waxenecker, Haoheng Yan, Lucia Zhang
Publikováno v:
Bioanalysis. 14:505-580
The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an overwhelmingly high number of nearly 900 professionals representing ph
Autor:
Surinder, Kaur, Stephen C, Alley, Matt, Szapacs, Amanda, Wilson, Eugene, Ciccimaro, Dian, Su, Neil, Henderson, Linzhi, Chen, Fabio, Garofolo, Shawna, Hengel, Wenying, Jian, John F, Kellie, Anita, Lee, John, Mehl, Joe, Palandra, Haibo, Qiu, Natasha, Savoie, Diaa, Shakleya, Ludovicus, Staelens, Hiroshi, Sugimoto, Giane, Sumner, Jan, Welink, Robert, Wheller, Y-J, Xue, Jianing, Zeng, Jinhui, Zhang, Huiyu, Zhou, Jian, Wang, Scott, Summerfield, Olga, Kavetska, Lieve, Dillen, Ragu, Ramanathan, Mike, Baratta, Arindam, Dasgupta, Anna, Edmison, Luca, Ferrari, Sally, Fischer, Daniela, Fraier, Sam, Haidar, Kathrin, Heermeier, Christopher, James, Allena, Ji, Lina, Luo, Gustavo Mendes, Lima Santos, Noah, Post, Anton I, Rosenbaum, Sune, Sporring, Sekhar, Surapaneni, Stephen, Vinter, Katty, Wan, Eric, Woolf, Seongeun Julia, Cho, Elham, Kossary, Sandra, Prior, Mohsen Rajabi, Abhari, Catherine, Soo, Yow-Ming, Wang, Abbas, Bandukwala, Elana, Cherry, Isabelle, Cludts, Soma, Ghosh, Shirley, Hopper, Akiko, Ishii-Watabe, Susan, Kirshner, Kevin, Maher, Kimberly, Maxfield, Joao, Pedras-Vasconcelos, Yoshiro, Saito, Dean, Smith, Therese, Solstad, Daniela, Verthelyi, Meenu, Wadhwa, Leslie, Wagner, Günter, Waxenecker, Haoheng, Yan, Lucia, Zhang
Publikováno v:
Bioanalysis. 14(9)
The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an overwhelmingly high number of nearly 900 professionals representing ph
Autor:
Luca Ferrari, Wenkui Li, Christopher P. Evans, Lieve Dillen, Noah Post, Jens Sydor, Jinhui Zhang, Susan Stojdl, Boris Gorovits, Jason Boer, Anita Lee, Mark G. Qian, Natasha Savoie, Kevin P. Bateman, Brian Dean, Allena J. Ji, Jiang Wu, Amanda Wilson, Michael H. Buonarati, Jian Wang, Gustavo Mendes Lima Santos, Daniel S Spellman, Hendrik Neubert, Hui Zhang, Scott G. Summerfield, Eric Yang, Nilufer Tampal, Parya Nouri, Christopher J Beaver, Anna Edmison, Christine Fandozzi, Troy Voelker, Jenny Zhang, Fabio Garofolo, Michael McGuinness, Sam Haidar, Bill Mylott, Stephen Vinter, Arindam Dasgupta, Patrick Faustino, Daniela Fraier, Wenying Jian, Tahseen Mirza, Sune Sporring, Diaa Shakleya, Timothy V Olah, Eric Woolf, Stephen C. Alley, Nicola Hughes, Suman Dandamudi, Hongbin Yu, Phillip Sundman, Rebecca Elliott, Lina Luo, Jan Welink
Publikováno v:
Bioanalysis. 13:203-238
The 14th edition of the Workshop on Recent Issues in Bioanalysis (14th WRIB) was held virtually on June 15–29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract r
Publikováno v:
Bioanalysis. 11:1909-1912
Autor:
Andrew F. Powers, John Matson, Shuling Guo, Sarah Greenlee, Kaitlyn A Tremble, A. Robert MacLeod, Mariam Aghajan, Noah Post, Joseph Ochaba
Publikováno v:
Nucleic Acids Research
Endocytosis is a mechanism by which cells sense their environment and internalize various nutrients, growth factors and signaling molecules. This process initiates at the plasma membrane, converges with autophagy, and terminates at the lysosome. It i
Autor:
A. Robert MacLeod, Youngsoo Kim, Noah Post, Thazha P. Prakash, Xiaokun Xiao, Stephanie Klein, Zhengfeng Yin, Joanna Schmidt, Tianyuan Zhou, Xiaolin Luo, Minji Jo
Publikováno v:
Molecular Therapy
Antisense oligonucleotides (ASOs) are a novel therapeutic approach to target difficult-to-drug protein classes by targeting their corresponding mRNAs. Significantly enhanced ASO activity has been achieved by the targeted delivery of ASOs to selected
Publikováno v:
Drug Metabolism and Disposition. 47:1164-1173
Volanesorsen (previously known as ISIS 304801) is a 20-nucleotide partially 2'-O-(2-methoxyethyl) (2'-MOE)-modified antisense oligonucleotide (ASO) gapmer, which was recently approved in the European Union as a novel, first-in-class treatment in the