Mezagitamab in systemic lupus erythematosus: clinical and mechanistic findings of CD38 inhibition in an autoimmune disease

Autor: Richard A Furie, Van Anh Nguyen, Feng Hong, Scott R P McDonnell, Noah M Walton, Carsten Merkwirth, Deborah Berg, Elena Tomaselli Muensterman

Publikováno v: Lupus Science and Medicine, Vol 11, Iss 1 (2024)

Objective To evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic lupus erythematosus (SLE).Methods A phase 1b double-blind, placebo-controlled, multicentre s

Externí odkaz: https://doaj.org/article/9545ba1275374259ad9a0a70853a795b

Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders

Autor: Hideo Hagihara, Keizo Takao, Noah M. Walton, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa

Publikováno v: Neural Plasticity, Vol 2013 (2013)

Adequate maturation of neurons and their integration into the hippocampal circuit is crucial for normal cognitive function and emotional behavior, and disruption of this process could cause disturbances in mental health. Previous reports have shown t

Externí odkaz: https://doaj.org/article/a384797a539c46ca9f7218cb4b0e0c81

Gastrin-Releasing Peptide Contributes to the Regulation of Adult Hippocampal Neurogenesis and Neuronal Development

Autor: Jeffrey H. Kogan, Shinichi Miyake, Anoek de Koning, Rick Shin, Noah M. Walton, Adam K. Gross, Kouichi Tamura, Katsunori Tajinda, Mitsuyuki Matsumoto, Xiuyuan Xie, Qian Chen, Carrie L. Heusner

Publikováno v: Stem Cells, 32(9), 2454-2466. Wiley-Blackwell
Walton, N M, de Koning, A, Xie, X Y, Shin, R, Chen, Q, Miyake, S, Tajinda, K, Gross, A K, Kogan, J H, Heusner, C L, Tamura, K & Matsumoto, M 2014, ' Gastrin-Releasing Peptide Contributes to the Regulation of Adult Hippocampal Neurogenesis and Neuronal Development ', Stem Cells, vol. 32, no. 9, pp. 2454-2466 . https://doi.org/10.1002/stem.1740

In the postnatal hippocampus, newly generated neurons contribute to learning and memory. Disruptions in neurogenesis and neuronal development have been linked to cognitive impairment and are implicated in a broad variety of neurological and psychiatr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de7058b073ff885ab0bc4cc3fe40968
https://doi.org/10.1002/stem.1740

SREB2/GPR85, a schizophrenia risk factor, negatively regulates hippocampal adult neurogenesis and neurogenesis‐dependent learning and memory

Autor: Qian Chen, Jeffrey H. Kogan, Shinichi Miyake, Yuan Zhou, Mitsuyuki Matsumoto, Carrie L. Heusner, Kouichi Tamura, Adam K. Gross, Katsunori Tajinda, Noah M. Walton, Rick Shin

Publikováno v: The European Journal of Neuroscience

SREB2/GPR85, a member of the super-conserved receptor expressed in brain (SREB) family, is the most conserved G-protein-coupled receptor in vertebrate evolution. Previous human and mouse genetic studies have indicated a possible link between SREB2 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f4afb87bb66857b191537c612b5a93
https://doi.org/10.1111/j.1460-9568.2012.08180.x

The radial glia antibody RC2 recognizes a protein encoded by Nestin

Autor: Frank Fuxiang Mao, Andy Peng Xiang, Donghyun Park, Bruce T. Lahn, Noah M. Walton, Li Zhang, Sun Shim Choi

Publikováno v: Biochemical and Biophysical Research Communications. 382:588-592

The RC2 antibody is widely used to label mouse radial glial cells in the developing central nervous system. While the antibody is known to recognize a 295-kDa intermediate filament proximal protein, the gene encoding the RC2 antigen remains to be ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8590fd09f16f6084ccdfb8c46f5ea520
https://doi.org/10.1016/j.bbrc.2009.03.074