A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.

Autor: Anurag Verma, Noah L Tsao, Lauren O Thomann, Yuk-Lam Ho, Sudha K Iyengar, Shiuh-Wen Luoh, Rotonya Carr, Dana C Crawford, Jimmy T Efird, Jennifer E Huffman, Adriana Hung, Kerry L Ivey, Michael G Levin, Julie Lynch, Pradeep Natarajan, Saiju Pyarajan, Alexander G Bick, Lauren Costa, Giulio Genovese, Richard Hauger, Ravi Madduri, Gita A Pathak, Renato Polimanti, Benjamin Voight, Marijana Vujkovic, Seyedeh Maryam Zekavat, Hongyu Zhao, Marylyn D Ritchie, VA Million Veteran Program COVID-19 Science Initiative, Kyong-Mi Chang, Kelly Cho, Juan P Casas, Philip S Tsao, J Michael Gaziano, Christopher O'Donnell, Scott M Damrauer, Katherine P Liao

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010113 (2022)

The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated wi

Externí odkaz: https://doaj.org/article/ffdb9e4bf94d4c729a4428cb28eaf0c9

Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors

Autor: Gabrielle Shakt, Noah L. Tsao, Michael G. Levin, Venexia Walker, Rachel L. Kember, Derek Klarin, Phil Tsao, Benjamin F. Voight, Salvatore T. Scali, Scott M. Damrauer

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 4 (2024)

Background Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationsh

Externí odkaz: https://doaj.org/article/085b73819b9b447d9b552f9eb92c1753

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Autor: Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han H. Wu, Ioanna Ntalla, Qin Hui, Derek Klarin, Austin T. Hilliard, Zeyuan Wang, Chao Xue, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Mi Yeong Hwang, Sohee Han, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Aki S. Havulinna, Yogasudha Veturi, Jennifer Allen Pacheco, Elisabeth A. Rosenthal, Todd Lingren, QiPing Feng, Iftikhar J. Kullo, Akira Narita, Jun Takayama, Hilary C. Martin, Karen A. Hunt, Bhavi Trivedi, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, Asif Rasheed, George Hindy, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Ananyo Choudhury, Dhriti Sengupta, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian’an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Noha A. Yousri, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Anne A. Bjerregaard, Jie Yao, Ani Manichaikul, Chii-Min Hwu, Yi-Jen Hung, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Pala Mauro, Floris Matteo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Møllehave, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, Sanni E. Ruotsalainen, EWarwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Miguel Vazquez-Moreno, Mary F. Feitosa, Mary K. Wojczynski, Zhe Wang, Michael H. Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Noah L. Tsao, Anurag Verma, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Ayşe Demirkan, Hampton L. Leonard, Jonathan Marten, Mirjam Frank, Börge Schmidt, Laura J. Smyth, Marisa Cañadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Suraj S. Nongmaithem, Swati Bayyana, Heather M. Stringham, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Gauri Prasad, Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Bernhard Banas, Giuseppe Giovanni Nardone, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Maria Pina Concas, Simona Vaccargiu, Peter J. van der Most, Niina Pitkänen, Brian E. Cade, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Amy R. Bentley, Ayo P. Doumatey, Adebowale A. Adeyemo, Jong Young Lee, Eva R. B. Petersen, Aneta A. Nielsen, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikäinen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hidalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica van Setten, Xiaoyin Li, Jingjing Liang, Hua Tang, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jäger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kähönen, Louis Pérusse, Claude Bouchard, Anke Tönjes, Yii-Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellström, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Martina E. Zimmermann, Henry Völzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Patricia A. Peyser, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Carsten A. Böger, Bettina Jung, Peter K. Joshi, David A. Bennett, Philip L. De Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Päivi Pajukanta, Teresa Tusié-Luna, Carlos A. Aguilar-Salinas, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka de Silva, Ananda R. Wickremasinghe, Ronald M. Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke Iden Hollander, Dwaipayan Bharadwaj, Adolfo Correa, James G. Wilson, Lars Lind, Chew-Kiat Heng, Amanda E. Nelson, Yvonne M. Golightly, James F. Wilson, Brenda Penninx, Hyung-Lae Kim, John Attia, Rodney J. Scott, D. C. Rao, Donna K. Arnett, Steven C. Hunt, Mark Walker, Heikki A. Koistinen, Giriraj R. Chandak, Josep M. Mercader, Maria C. Costanzo, Dongkeun Jang, Noël P. Burtt, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage, EShyong Tai, Rob M. van Dam, Terho Lehtimäki, Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F. Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Jöckel, Mark I. McCarthy, Colin N. A. Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M. van Duijn, Zi-Bing Jin, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried März, Vilmundur Gudnason, Jean-Claude Tardif, Guillaume Lettre, Leen M.‘t Hart, Petra J. M. Elders, Scott M. Damrauer, Meena Kumari, Mika Kivimaki, Pim van der Harst, Tim D. Spector, Ruth J. F. Loos, Michael A. Province, Esteban J. Parra, Miguel Cruz, Bruce M. Psaty, Ivan Brandslund, Peter P. Pramstaller, Charles N. Rotimi, Kaare Christensen, Samuli Ripatti, Elisabeth Widén, Hakon Hakonarson, Struan F. A. Grant, Lambertus A. L. M. Kiemeney, Jacqueline de Graaf, Markus Loeffler, Florian Kronenberg, Dongfeng Gu, Jeanette Erdmann, Heribert Schunkert, Paul W. Franks, Allan Linneberg, J. Wouter Jukema, Amit V. Khera, Minna Männikkö, Marjo-Riitta Jarvelin, Zoltan Kutalik, Cucca Francesco, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Hugh Watkins, David P. Strachan, Niels Grarup, Peter Sever, Neil Poulter, Lee-Ming Chuang, Jerome I. Rotter, Thomas M. Dantoft, Fredrik Karpe, Matt J. Neville, Nicholas J. Timpson, Ching-Yu Cheng, Tien-Yin Wong, Chiea Chuen Khor, Hengtong Li, Charumathi Sabanayagam, Annette Peters, Christian Gieger, Andrew T. Hattersley, Nancy L. Pedersen, Patrik K. E. Magnusson, Dorret I. Boomsma, Allegonda H. M. Willemsen, LAdrienne Cupples, Joyce B. J. van Meurs, Mohsen Ghanbari, Penny Gordon-Larsen, Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J. Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson, Goncalo Abecasis, John C. Chambers, Jaspal S. Kooner, Paul S. de Vries, Alanna C. Morrison, Scott Hazelhurst, Michèle Ramsay, Kari E. North, Martha Daviglus, Peter Kraft, Nicholas G. Martin, John B. Whitfield, Shahid Abbas, Danish Saleheen, Robin G. Walters, Michael V. Holmes, Corri Black, Blair H. Smith, Aris Baras, Anne E. Justice, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Charles Kooperberg, Gen Tamiya, Masayuki Yamamoto, David A. van Heel, Richard C. Trembath, Wei-Qi Wei, Gail P. Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D. Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjørn Olav Åsvold, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada, Yoshinori Murakami, Bong-Jo Kim, Unnur Thorsteinsdottir, Kari Stefansson, Jifeng Zhang, YEugene Chen, Yuk-Lam Ho, Julie A. Lynch, Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, John M. Gaziano, Peter W. F. Wilson, Timothy M. Frayling, Joel N. Hirschhorn, Sekar Kathiresan, Karen L. Mohlke, Yan V. Sun, Andrew P. Morris, Michael Boehnke, Christopher D. Brown, Pradeep Natarajan, Panos Deloukas, Cristen J. Willer, Themistocles L. Assimes, Gina M. Peloso

Publikováno v: Genome Biology, 23(1):268. Springer Verlag
Genome Biology, 23:268. BMC
Genome biology, vol. 23, no. 1, pp. 268
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Mitchell, R E, Chai, J F, Aadahl, M, Bjerregaard, A A, Yao, J, Manichaikul, A, Hwu, C-M, Hung, Y-J, Warren, H R, Ramirez, J, Bork-Jensen, J, Kårhus, L L, Goel, A, Sabater-Lleal, M, Noordam, R, Mauro, P, Matteo, F, McDaid, A F, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Møllehave, L T, Munz, M, Zeng, L, Huang, J, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, T E, Bradfield, J P, Ruotsalainen, S E, Daw, EW, Zmuda, J M, Mitchell, J S, Fuchsberger, C, Christensen, H, Brody, J A, Vazquez-Moreno, M, Feitosa, M F, Wojczynski, M K, Wang, Z, Preuss, M H, Mangino, M, Christofidou, P, Verweij, N, Benjamins, J W, Engmann, J, Tsao, N L, Verma, A, Slieker, R C, Lo, K S, Zilhao, N R, Le, P, Kleber, M E, Delgado, G E, Huo, S, Ikeda, D D, Iha, H, Yang, J, Liu, J, Demirkan, A, Leonard, H L, Marten, J, Frank, M, Schmidt, B, Smyth, L J, Cañadas-Garre, M, Wang, C, Nakatochi, M, Wong, A, Hutri-Kähönen, N, Sim, X, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, J C, Lyssenko, V, Nongmaithem, S S, Bayyana, S, Stringham, H M, Irvin, M R, Oldmeadow, C, Kim, H-N, Ryu, S, Timmers, P R H J, Arbeeva, L, Dorajoo, R, Lange, L A, Prasad, G, Lorés-Motta, L, Pauper, M, Long, J, Li, X, Theusch, E, Takeuchi, F, Spracklen, C N, Loukola, A, Bollepalli, S, Warner, S C, Wang, Y X, Wei, W B, Nutile, T, Ruggiero, D, Sung, Y J, Chen, S, Liu, F, Yang, J, Kentistou, K A, Banas, B, Nardone, G G, Meidtner, K, Bielak, L F, Smith, J A, Hebbar, P, Farmaki, A-E, Hofer, E, Lin, M, Concas, M P, Vaccargiu, S, van der Most, P J, Pitkänen, N, Cade, B E, van der Laan, S W, Chitrala, K N, Weiss, S, Bentley, A R, Doumatey, A P, Adeyemo, A A, Lee, J Y, Petersen, E R B, Nielsen, A A, Choi, H S, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, N W, Wang, C A, Lin, S-Y, Wang, J-S, Couture, C, Lyytikäinen, L-P, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hidalgo, B, Giannakopoulou, O, Cai, Q, Obura, M O, van Setten, J, Li, X, Liang, J, Tang, H, Terzikhan, N, Shin, J H, Jackson, R D, Reiner, A P, Martin, L W, Chen, Z, Li, L, Kawaguchi, T, Thiery, J, Bis, J C, Launer, L J, Li, H, Nalls, M A, Raitakari, O T, Ichihara, S, Wild, S H, Nelson, C P, Campbell, H, Jäger, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, P S, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, de Kleijn, D, de Borst, G J, Kim, E K, Adams, H H H, Ikram, M A, Zhu, X, Asselbergs, F W, Kraaijeveld, A O, Beulens, J W J, Shu, X-O, Rallidis, L S, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, A W, Kähönen, M, Pérusse, L, Bouchard, C, Tönjes, A, Chen, Y-D I, Pennell, C E, Mori, T A, Lieb, W, Franke, A, Ohlsson, C, Mellström, D, Cho, Y S, Lee, H, Yuan, J-M, Koh, W-P, Rhee, S Y, Woo, J-T, Heid, I M, Stark, K J, Zimmermann, M E, Völzke, H, Homuth, G, Evans, M K, Zonderman, A B, Polasek, O, Pasterkamp, G, Hoefer, I E, Redline, S, Pahkala, K, Oldehinkel, A J, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Bandinelli, S, Dedoussis, G, Thanaraj, T A, Kardia, S L R, Peyser, P A, Kato, N, Schulze, M B, Girotto, G, Böger, C A, Jung, B, Joshi, P K, Bennett, D A, De Jager, P L, Lu, X, Mamakou, V, Brown, M, Caulfield, M J, Munroe, P B, Guo, X, Ciullo, M, Jonas, J B, Samani, N J, Kaprio, J, Pajukanta, P, Tusié-Luna, T, Aguilar-Salinas, C A, Adair, L S, Bechayda, S A, de Silva, H J, Wickremasinghe, A R, Krauss, R M, Wu, J-Y, Zheng, W, Hollander, A I, Bharadwaj, D, Correa, A, Wilson, J G, Lind, L, Heng, C-K, Nelson, A E, Golightly, Y M, Wilson, J F, Penninx, B, Kim, H-L, Attia, J, Scott, R J, Rao, D C, Arnett, D K, Hunt, S C, Walker, M, Koistinen, H A, Chandak, G R, Mercader, J M, Costanzo, M C, Jang, D, Burtt, N P, Villalpando, C G, Orozco, L, Fornage, M, Tai, ES, van Dam, R M, Lehtimäki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, D F, McKnight, A J, Kee, F, Jöckel, K-H, McCarthy, M I, Palmer, C N A, Vitart, V, Hayward, C, Simonsick, E, van Duijn, C M, Jin, Z-B, Qu, J, Hishigaki, H, Lin, X, März, W, Gudnason, V, Tardif, J-C, Lettre, G, Hart, L M, Elders, P J M, Damrauer, S M, Kumari, M, Kivimaki, M, van der Harst, P, Spector, T D, Loos, R J F, Province, M A, Parra, E J, Cruz, M, Psaty, B M, Brandslund, I, Pramstaller, P P, Rotimi, C N, Christensen, K, Ripatti, S, Widén, E, Hakonarson, H, Grant, S F A, Kiemeney, L A L M, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, D, Erdmann, J, Schunkert, H, Franks, P W, Linneberg, A, Jukema, J W, Khera, A V, Männikkö, M, Jarvelin, M-R, Kutalik, Z, Francesco, C, Mook-Kanamori, D O, van Dijk, K W, Watkins, H, Strachan, D P, Grarup, N, Sever, P, Poulter, N, Chuang, L-M, Rotter, J I, Dantoft, T M, Karpe, F, Neville, M J, Timpson, N J, Cheng, C-Y, Wong, T-Y, Khor, C C, Li, H, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, A T, Pedersen, N L, Magnusson, P K E, Boomsma, D I, Willemsen, A H M, Cupples, LA, van Meurs, J B J, Ghanbari, M, Gordon-Larsen, P, Huang, W, Kim, Y J, Tabara, Y, Wareham, N J, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, J C, Kooner, J S, de Vries, P S, Morrison, A C, Hazelhurst, S, Ramsay, M, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Baras, A, Justice, A E, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, D A, Trembath, R C, Wei, W-Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Åsvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, B-J, Thorsteinsdottir, U, Stefansson, K, Zhang, J, Chen, YE, Ho, Y-L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K-M, Cho, K, O'Donnell, C J, Gaziano, J M, Wilson, P W F, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Mohlke, K L, Sun, Y V, Morris, A P, Boehnke, M, Natarajan, P, Deloukas, P, Willer, C J, Assimes, T L & Peloso, G M 2022, ' Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ', Genome biology, vol. 23, no. 1, 268 . https://doi.org/10.1186/s13059-022-02837-1
Kanoni, S, Graham, S E, Wang, Y, Surakka, I, Ramdas, S, Zhu, X, Clarke, S L, Bhatti, K F, Vedantam, S, Winkler, T W, Locke, A E, Marouli, E, Zajac, G J M, Wu, K H H, Ntalla, I, Hui, Q, Klarin, D, Hilliard, A T, Wang, Z, Xue, C, Thorleifsson, G, Helgadottir, A, Gudbjartsson, D F, Holm, H, Olafsson, I, Hwang, M Y, Han, S, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, B M, Rasheed, H, Havulinna, A S, Veturi, Y, Pacheco, J A, Rosenthal, E A, Lingren, T, Feng, Q P, Kullo, I J, Narita, A, Takayama, J, Martin, H C, Hunt, K A, Trivedi, B, Haessler, J, Giulianini, F, Bradford, Y, Miller, J E, Campbell, A, Lin, K, Millwood, I Y, Rasheed, A, Hindy, G, Faul, J D, Zhao, W, Weir, D R, Turman, C, Huang, H, Graff, M, Choudhury, A, Sengupta, D, Mahajan, A, Brown, M R, Zhang, W, Yu, K, Schmidt, E M, Pandit, A, Gustafsson, S, Yin, X, Luan, J, Zhao, J H, Matsuda, F, Jang, H M, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, J J, Wood, A R, Ji, Y, Gao, Z, Haworth, S, Yousri, N A, Mitchell, R E, Chai, J F, Aadahl, M, Bjerregaard, A A, Yao, J, Manichaikul, A, Hwu, C M, Hung, Y J, Warren, H R, Ramirez, J, Bork-Jensen, J, Kårhus, L L, Goel, A, Sabater-Lleal, M, Noordam, R, Mauro, P, Matteo, F, McDaid, A F, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Møllehave, L T, Munz, M, Zeng, L, Huang, J, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, T E, Bradfield, J P, Ruotsalainen, S E, Daw, EW, Zmuda, J M, Mitchell, J S, Fuchsberger, C, Christensen, H, Brody, J A, Vazquez-Moreno, M, Feitosa, M F, Wojczynski, M K, Wang, Z, Preuss, M H, Mangino, M, Christofidou, P, Verweij, N, Benjamins, J W, Engmann, J, Tsao, N L, Verma, A, Slieker, R C, Lo, K S, Zilhao, N R, Le, P, Kleber, M E, Delgado, G E, Huo, S, Ikeda, D D, Iha, H, Yang, J, Liu, J, Demirkan, A, Leonard, H L, Marten, J, Frank, M, Schmidt, B, Smyth, L J, Cañadas-Garre, M, Wang, C, Nakatochi, M, Wong, A, Hutri-Kähönen, N, Sim, X, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, J C, Lyssenko, V, Nongmaithem, S S, Bayyana, S, Stringham, H M, Irvin, M R, Oldmeadow, C, Kim, H N, Ryu, S, Timmers, P R H J, Arbeeva, L, Dorajoo, R, Lange, L A, Prasad, G, Lorés-Motta, L, Pauper, M, Long, J, Li, X, Theusch, E, Takeuchi, F, Spracklen, C N, Loukola, A, Bollepalli, S, Warner, S C, Wang, Y X, Wei, W B, Nutile, T, Ruggiero, D, Sung, Y J, Chen, S, Liu, F, Yang, J, Kentistou, K A, Banas, B, Nardone, G G, Meidtner, K, Bielak, L F, Smith, J A, Hebbar, P, Farmaki, A E, Hofer, E, Lin, M, Concas, M P, Vaccargiu, S, van der Most, P J, Pitkänen, N, Cade, B E, van der Laan, S W, Chitrala, K N, Weiss, S, Bentley, A R, Doumatey, A P, Adeyemo, A A, Lee, J Y, Petersen, E R B, Nielsen, A A, Choi, H S, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, N W, Wang, C A, Lin, S Y, Wang, J S, Couture, C, Lyytikäinen, L P, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hidalgo, B, Giannakopoulou, O, Cai, Q, Obura, M O, van Setten, J, Li, X, Liang, J, Tang, H, Terzikhan, N, Shin, J H, Jackson, R D, Reiner, A P, Martin, L W, Chen, Z, Li, L, Kawaguchi, T, Thiery, J, Bis, J C, Launer, L J, Li, H, Nalls, M A, Raitakari, O T, Ichihara, S, Wild, S H, Nelson, C P, Campbell, H, Jäger, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, P S, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, de Kleijn, D, de Borst, G J, Kim, E K, Adams, H H H, Ikram, M A, Zhu, X, Asselbergs, F W, Kraaijeveld, A O, Beulens, J W J, Shu, X O, Rallidis, L S, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, A W, Kähönen, M, Pérusse, L, Bouchard, C, Tönjes, A, Chen, Y D I, Pennell, C E, Mori, T A, Lieb, W, Franke, A, Ohlsson, C, Mellström, D, Cho, Y S, Lee, H, Yuan, J M, Koh, W P, Rhee, S Y, Woo, J T, Heid, I M, Stark, K J, Zimmermann, M E, Völzke, H, Homuth, G, Evans, M K, Zonderman, A B, Polasek, O, Pasterkamp, G, Hoefer, I E, Redline, S, Pahkala, K, Oldehinkel, A J, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Bandinelli, S, Dedoussis, G, Thanaraj, T A, Kardia, S L R, Peyser, P A, Kato, N, Schulze, M B, Girotto, G, Böger, C A, Jung, B, Joshi, P K, Bennett, D A, De Jager, P L, Lu, X, Mamakou, V, Brown, M, Caulfield, M J, Munroe, P B, Guo, X, Ciullo, M, Jonas, J B, Samani, N J, Kaprio, J, Pajukanta, P, Tusié-Luna, T, Aguilar-Salinas, C A, Adair, L S, Bechayda, S A, de Silva, H J, Wickremasinghe, A R, Krauss, R M, Wu, J Y, Zheng, W, Hollander, A I, Bharadwaj, D, Correa, A, Wilson, J G, Lind, L, Heng, C K, Nelson, A E, Golightly, Y M, Wilson, J F, Penninx, B, Kim, H L, Attia, J, Scott, R J, Rao, D C, Arnett, D K, Hunt, S C, Walker, M, Koistinen, H A, Chandak, G R, Mercader, J M, Costanzo, M C, Jang, D, Burtt, N P, Villalpando, C G, Orozco, L, Fornage, M, Tai, ES, van Dam, R M, Lehtimäki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, D F, McKnight, A J, Kee, F, Jöckel, K H, McCarthy, M I, Palmer, C N A, Vitart, V, Hayward, C, Simonsick, E, van Duijn, C M, Jin, Z B, Qu, J, Hishigaki, H, Lin, X, März, W, Gudnason, V, Tardif, J C, Lettre, G, Hart, L M T, Elders, P J M, Damrauer, S M, Kumari, M, Kivimaki, M, van der Harst, P, Spector, T D, Loos, R J F, Province, M A, Parra, E J, Cruz, M, Psaty, B M, Brandslund, I, Pramstaller, P P, Rotimi, C N, Christensen, K, Ripatti, S, Widén, E, Hakonarson, H, Grant, S F A, Kiemeney, L A L M, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, D, Erdmann, J, Schunkert, H, Franks, P W, Linneberg, A, Jukema, J W, Khera, A V, Männikkö, M, Jarvelin, M R, Kutalik, Z, Francesco, C, Mook-Kanamori, D O, van Dijk, K W, Watkins, H, Strachan, D P, Grarup, N, Sever, P, Poulter, N, Chuang, L M, Rotter, J I, Dantoft, T M, Karpe, F, Neville, M J, Timpson, N J, Cheng, C Y, Wong, T Y, Khor, C C, Li, H, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, A T, Pedersen, N L, Magnusson, P K E, Boomsma, D I, Willemsen, A H M, Cupples, LA, van Meurs, J B J, Ghanbari, M, Gordon-Larsen, P, Huang, W, Kim, Y J, Tabara, Y, Wareham, N J, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, J C, Kooner, J S, de Vries, P S, Morrison, A C, Hazelhurst, S, Ramsay, M, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Baras, A, Justice, A E, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, D A, Trembath, R C, Wei, W Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Åsvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, B J, Thorsteinsdottir, U, Stefansson, K, Zhang, J, Chen, YE, Ho, Y L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K M, Cho, K, O'Donnell, C J, Gaziano, J M, Wilson, P W F, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Mohlke, K L, Sun, Y V, Morris, A P, Boehnke, M, Brown, C D, Natarajan, P, Deloukas, P, Willer, C J, Assimes, T L & Peloso, G M 2022, ' Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ', Genome Biology, vol. 23, no. 1, 268 . https://doi.org/10.1186/s13059-022-02837-1
Genome Biology, 23, 1
Genome Biology, 23(1). BMC
Genome Biology, 23(1):268. BioMed Central Ltd.
Kanoni, S, Graham, S E, Wang, Y, Hottenga, J J, Penninx, B, Boomsma, D I, Willemsen, G, Willer, C J, Assimes, T L, Peloso, G M & Global Lipids Genetics Consortium 2022, ' Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ', Genome Biology, vol. 23, no. 1, 268 . https://doi.org/10.1186/s13059-022-02837-1
Genome Biology
Genome Biology, 23
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Mitchell, R E, Chai, J F, Aadahl, M, Bjerregaard, A A, Yao, J, Manichaikul, A, Hwu, C-M, Hung, Y-J, Warren, H R, Ramirez, J, Bork-Jensen, J, Kårhus, L L, Goel, A, Sabater-Lleal, M, Noordam, R, Mauro, P, Matteo, F, McDaid, A F, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Møllehave, L T, Munz, M, Zeng, L, Huang, J, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, T E, Bradfield, J P, Ruotsalainen, S E, Daw, E W, Zmuda, J M, Mitchell, J S, Fuchsberger, C, Christensen, H, Brody, J A, Vazquez-Moreno, M, Feitosa, M F, Wojczynski, M K, Wang, Z, Preuss, M H, Mangino, M, Christofidou, P, Verweij, N, Benjamins, J W, Engmann, J, Tsao, N L, Verma, A, Slieker, R C, Lo, K S, Zilhao, N R, le, P, Kleber, M E, Delgado, G E, Huo, S, Ikeda, D D, Iha, H, Yang, J, Liu, J, Demirkan, A, Leonard, H L, Marten, J, Frank, M, Schmidt, B R, Smyth, L J, Cañadas-Garre, M, Wang, C, Nakatochi, M, Wong, A, Hutri-Kähönen, N, Sim, X, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, J C, 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Ramsay, M, North, K E, Daviglus, M, Kraft, P, Martin, N G, Whitfield, J B, Abbas, S, Saleheen, D, Walters, R G, Holmes, M V, Black, C, Smith, B H, Baras, A, Justice, A E, Buring, J E, Ridker, P M, Chasman, D I, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, D A, Trembath, R C, Wei, W-Q, Jarvik, G P, Namjou, B, Hayes, M G, Ritchie, M D, Jousilahti, P, Salomaa, V, Hveem, K, Åsvold, B O, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, B-J, Thorsteinsdottir, U, Stefansson, K, Zhang, J, Chen, Y E, Ho, Y-L, Lynch, J A, Rader, D J, Tsao, P S, Chang, K-M, Cho, K, O’Donnell, C J, Gaziano, J M, Wilson, P W F, Frayling, T M, Hirschhorn, J N, Kathiresan, S, Mohlke, K L, Sun, Y V, Morris, A P, Boehnke, M, Brown, C D, Natarajan, P, Deloukas, P, Willer, C J, Assimes, T L & Peloso, G M 2022, ' Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis ', Genome Biology, vol. 23, no. 1, 268 . https://doi.org/10.1186/s13059-022-02837-1
Genome Biol. 23:268 (2022)

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea2b9dfd52b0ec731c7927b5bf8400b
https://research.vu.nl/en/publications/9ce639f6-4d7e-4365-a087-bce0a6721e09

Metabolite Patterns of Patients With Peripheral Arterial Disease In Response To Exercise

Autor: Gabrielle Shakt, Sarah J. Ractcliffe, Scott M. Damrauer, Oliver Fiehn, John W. Newman, Kamil Borkowski, Tiffany R. Bellomo, Thomas F. Floyd, Hillary Johnston-Cox, Renae Judy, Noah L. Tsao, Felix W. Wehrli

Supervised exercise therapy (SET) is an effective intervention for symptomatic peripheral artery disease. Its effect on metabolism, measured by the circulating metabolome is not well understood. Participants underwent the Gardner graded treadmill tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a35e37a340a432425a2da5aeaed5111
https://doi.org/10.21203/rs.3.rs-1068579/v1

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program

Autor: Sudha K Iyengar, Shiuh-Wen Luoh, Julie Lynch, Jimmy T. Efird, Kelly Cho, Anurag Verma, Ravi Madduri, Noah L. Tsao, Lauren O Thomann, Juan P Casas, Saiju Pyarajan, Richard L. Hauger, Benjamin F. Voight, Marijana Vujkovic, Kerry L. Ivey, Christopher O Donnell, J. Michael Gaziano, Michael G. Levin, Rotonya M. Carr, Dana C. Crawford, Giulio Genovese, Scott M. Damrauer, Gita A. Pathak, Yuk-Lam Ho, Katherine P. Liao, Alexander G. Bick, Pradeep Natarajan, Kyong-Mi Chang, Renato Polimanti, Lauren Costa, Hongyu Zhao, Marylyn D. Ritchie, Philip S. Tsao, Maryam Zekavat, Adriana Hung

Publikováno v: medRxiv

The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c5c316f5942628c5fedeff8371b33
https://pubmed.ncbi.nlm.nih.gov/35482673