Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Noah J. Kessler"'
Autor:
Amir D. Hay, Noah J. Kessler, Daniel Gebert, Nozomi Takahashi, Hugo Tavares, Felipe K. Teixeira, Anne C. Ferguson-Smith
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract DNA methylation at the CpG dinucleotide is considered a stable epigenetic mark due to its presumed long-term inheritance through clonal expansion. Here, we perform high-throughput bisulfite sequencing on clonally derived somatic cell lines t
Externí odkaz:
https://doaj.org/article/e2316b0d639a469ead1b7754816be313
Autor:
Prachand Issarapu, Manisha Arumalla, Hannah R. Elliott, Suraj S. Nongmaithem, Alagu Sankareswaran, Modupeh Betts, Sara Sajjadi, Noah J. Kessler, Swati Bayyana, Sohail R. Mansuri, Maria Derakhshan, G. V. Krishnaveni, Smeeta Shrestha, Kalyanaraman Kumaran, Chiara Di Gravio, Sirazul A. Sahariah, Eleanor Sanderson, Caroline L. Relton, Kate A. Ward, Sophie E. Moore, Andrew M. Prentice, Karen A. Lillycrop, Caroline H. D. Fall, Matt J. Silver, Giriraj R. Chandak, the EMPHASIS study group
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Human height is strongly influenced by genetics but the contribution of modifiable epigenetic factors is under-explored, particularly in low and middle-income countries (LMIC). We investigate links between blood DNA methylation and child hei
Externí odkaz:
https://doaj.org/article/ea9bc0f20bff47a5b3eb1876f8c6f819
Autor:
James H. Cross, Ousman Jarjou, Nuredin Ibrahim Mohammed, Santiago Rayment Gomez, Bubacarr J. B. Touray, Noah J. Kessler, Andrew M. Prentice, Carla Cerami
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Human neonates elicit a profound hypoferremia which may protect against bacterial sepsis. We examined the transience of this hypoferremia by measuring iron and its chaperone proteins, inflammatory and haematological parameters over the first
Externí odkaz:
https://doaj.org/article/1a4d4ed3f0ac4880b0da639377c7f82b
Autor:
Jessica L. Elmer, Amir D. Hay, Noah J. Kessler, Tessa M. Bertozzi, Eve A. C. Ainscough, Anne C. Ferguson-Smith
Publikováno v:
Mobile DNA, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Transposable elements (TEs) are enriched in cytosine methylation, preventing their mobility within the genome. We previously identified a genome-wide repertoire of candidate intracisternal A particle (IAP) TEs in mice that exhibit
Externí odkaz:
https://doaj.org/article/adf7dc0066924ceb83c4919b87a03967
Autor:
Chathura J. Gunasekara, C. Anthony Scott, Eleonora Laritsky, Maria S. Baker, Harry MacKay, Jack D. Duryea, Noah J. Kessler, Garrett Hellenthal, Alexis C. Wood, Kelly R. Hodges, Manisha Gandhi, Amy B. Hair, Matt J. Silver, Sophie E. Moore, Andrew M. Prentice, Yumei Li, Rui Chen, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background DNA methylation is thought to be an important determinant of human phenotypic variation, but its inherent cell type specificity has impeded progress on this question. At exceptional genomic regions, interindividual variation in DN
Externí odkaz:
https://doaj.org/article/5ad1e273b23e4b7b8400bfdedb7d6255
Autor:
Timothy E. Van Baak, Cristian Coarfa, Pierre-Antoine Dugué, Giovanni Fiorito, Eleonora Laritsky, Maria S. Baker, Noah J. Kessler, Jianrong Dong, Jack D. Duryea, Matt J. Silver, Ayden Saffari, Andrew M. Prentice, Sophie E. Moore, Akram Ghantous, Michael N. Routledge, Yun Yun Gong, Zdenko Herceg, Paolo Vineis, Gianluca Severi, John L. Hopper, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-20 (2018)
Abstract Background Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic similarities of monozygotic twins have been assumed to be largely due to th
Externí odkaz:
https://doaj.org/article/d717c5547306414888fccbb11bec07c0
Autor:
Matt J Silver, Ayden Saffari, Noah J Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M Prentice
Publikováno v:
eLife, Vol 11 (2022)
In humans, DNA methylation marks inherited from gametes are largely erased following fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of seasonal variation including changes in diet and nutritional stat
Externí odkaz:
https://doaj.org/article/3e0df17bd8c3409aa09b5b63f8a77876
Autor:
Amir D. Hay, Noah J. Kessler, Daniel Gebert, Nozomi Takahashi, Hugo Tavares, Felipe K. Teixeira, Anne C. Ferguson-Smith
DNA methylation is considered a stable epigenetic mark due to its presumed long-term inheritance through cell divisions. Here, we perform high-throughput bisulfite sequencing on clonally derived cell lines to quantitatively measure mitotic methylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76f079cb399765c447912061f9fa093
https://doi.org/10.1101/2023.01.27.525699
https://doi.org/10.1101/2023.01.27.525699
Autor:
Maria Derakhshan, Noah J Kessler, Miho Ishida, Charalambos Demetriou, Nicolas Brucato, Gudrun E Moore, Caroline H D Fall, Giriraj R Chandak, Francois-Xavier Ricaut, Andrew M Prentice, Garrett Hellenthal, Matt J Silver
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (12), pp.6735-6752. ⟨10.1093/nar/gkac503⟩
Nucleic Acids Research, 2022, 50 (12), pp.6735-6752. ⟨10.1093/nar/gkac503⟩
We analysed DNA methylation data from 30 datasets comprising 3474 individuals, 19 tissues and 8 ethnicities at CpGs covered by the Illumina450K array. We identified 4143 hypervariable CpGs (‘hvCpGs’) with methylation in the top 5% most variable s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae458740f23f467577d189ea55c9238
https://pubmed.ncbi.nlm.nih.gov/35713545
https://pubmed.ncbi.nlm.nih.gov/35713545
Autor:
Matt J Silver, Ayden Saffari, Noah J Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M Prentice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e509c76fda43a454608a39b086e5bb3
https://doi.org/10.7554/elife.72031.sa2
https://doi.org/10.7554/elife.72031.sa2