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Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism

Autor: William W. Cruikshank, Wei Chen, Konstantin V. Salojin, Craig Meagher, Qing Sheng Mi, Noah Horst, Josh Beilke, G A Arreaza, Terry L. Delovitch

Publikováno v: Diabetes

OBJECTIVE The progressive infiltration of pancreatic islets by lymphocytes is mandatory for development of autoimmune type 1 diabetes. This inflammatory process is mediated by several mediators that are potential therapeutic targets to arrest develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5189609b404eafa2e265a8b4d2b14d7f
https://doi.org/10.2337/db09-0131

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Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression

Autor: Terry J. Smith, Andrew G. Gianoukakis, Leon J. Martino, William W. Cruikshank, Noah Horst

Publikováno v: Endocrinology. 144(7)

Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1 to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3835abda93d31e3b288802105ae7693
https://pubmed.ncbi.nlm.nih.gov/12810540

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Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway

Autor: Noah Horst, Jane Pritchard, Rui Han, Terry J. Smith, William W. Cruikshank

Publikováno v: Scopus-Elsevier

Graves’ disease (GD) is associated with T cell infiltration, but the mechanism for lymphocyte trafficking has remained uncertain. We reported previously that fibroblasts from patients with GD express IL-16, a CD4-specific chemoattractant, and RANTE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4897b6acc9aa228c5f65fea74ddbb21c
https://pubmed.ncbi.nlm.nih.gov/12794168

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Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts

Autor: Jane Pritchard, Terry J. Smith, Noah Horst, William W. Cruikshank

Publikováno v: Scopus-Elsevier

Thyroid-associated ophthalmopathy and dermopathy are connective tissue manifestations of Graves’ disease (GD). Tissue remodeling is a prominent feature of both and is apparently driven by recruited T cells. In this study, we report that IgG isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b86a0ea9406565c30979fa6975480aa
https://pubmed.ncbi.nlm.nih.gov/11777993

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Synovial fibroblasts from patients with rheumatoid arthritis, like fibroblasts from Graves' disease, express high levels of IL-16 when treated with Igs against insulin-like growth factor-1 receptor

Autor: Noah Horst, Jane Pritchard, Terry J. Smith, William W. Cruikshank, Shanli Tsui

Publikováno v: Scopus-Elsevier

We have reported recently that IgG from patients with Graves’ disease (GD) can induce the expression of the CD4-specific T lymphocyte chemoattractant, IL-16, and RANTES, a C-C chemokine, in their fibroblasts. This induction is mediated through the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e835d84163af7b4e117b7df2dc01424
http://www.scopus.com/inward/record.url?eid=2-s2.0-4344640489&partnerID=MN8TOARS

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