Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Noah H. Watkins"'
Autor:
Ulrich Bierbach, Shenjie Zhang, Sofia R. Caruso, Noah H. Watkins, P. Keegan Rose, Cynthia S. Day, Xiyuan Yao
Publikováno v:
Angew Chem Int Ed Engl
A structure-activity relationship study was performed for a set of rigidified platinum-acridine anticancer agents containing linkers derived from chiral pyrrolidine and piperidine scaffolds. Screening a library of microscale reactions and selected re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bbf9fbf50f840dc43bc6f16def9114
https://doi.org/10.1002/anie.202009983
https://doi.org/10.1002/anie.202009983
Autor:
John T. Sloop, P. Keegan Rose, George L. Donati, Shenjie Zhang, Xiyuan Yao, Cynthia S. Day, Ikeer Y. Mancera-Ortiz, Noah H. Watkins, Ulrich Bierbach
Publikováno v:
Inorganica Chimica Acta. 492:150-155
Three new derivatives of a platinum–acridine hybrid anticancer agent were synthesized using nitrile–amine coupling (amidination) chemistry. In the new structures, the nonleaving group propane-1,3-diamine (pn) of a previously optimized analogue (h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed8fa46ba8e89692c374dd1d6d48cc7
https://doi.org/10.1016/j.ica.2019.04.030
https://doi.org/10.1016/j.ica.2019.04.030
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feff5782a5b49744d079ff59edb8a90c
https://pubmed.ncbi.nlm.nih.gov/32939009
https://pubmed.ncbi.nlm.nih.gov/32939009