Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Noah B. Herrington"'
Autor:
Forum Kayastha, Noah B. Herrington, Bandish Kapadia, Anirban Roychowdhury, Nahid Nanaji, Glen E. Kellogg, Ronald B. Gartenhaus
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-18 (2022)
Abstract Background Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents the dependency on oncogenic signaling, a significant factor in current s
Externí odkaz:
https://doaj.org/article/bb12c8386e4c491e9979d7a0e964c2d5
Autor:
Mohammed H. AL Mughram, Claudio Catalano, Noah B. Herrington, Martin K. Safo, Glen E. Kellogg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The aliphatic hydrophobic amino acid residues—alanine, isoleucine, leucine, proline and valine—are among the most common found in proteins. Their structural role in proteins is seemingly obvious: engage in hydrophobic interactions to stabilize se
Externí odkaz:
https://doaj.org/article/f2ff01d0b7c34a5fa6fa2a27bb25f10f
Autor:
Noah B. Herrington, Glen E. Kellogg
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Aspartic acid, glutamic acid and histidine are ionizable residues occupying various protein environments and perform many different functions in structures. Their roles are tied to their acid/base equilibria, solvent exposure, and backbone conformati
Externí odkaz:
https://doaj.org/article/661eb5cfa9c04bbf95a0feaa5eb06e6c
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100055- (2021)
Knowledge of three-dimensional protein structure is integral to most modern drug discovery efforts. Recent advancements have highlighted new techniques for 3D protein structure determination and, where structural data cannot be collected experimental
Externí odkaz:
https://doaj.org/article/5aa080215e094a3ea3907a6adbe898f8
Abstract LB023: Discovery, development and characterization of potent and selective USP11 inhibitors
Autor:
Forum Kayastha, Bandish Kapadia, Noah B. Herrington, Anirban Roychowdhury, Glen E. Kellogg, Ronald B. Gartenhaus
Publikováno v:
Cancer Research. 83:LB023-LB023
Ubiquitin-mediated events are emerging as the gatekeeper in cell proliferation, and the recognition of deubiquitinating enzymes (DUBs) as the critical regulators of these processes is rapidly growing. Several studies in the last decade confirmed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537bd27f539ff4851cc80d2da7d31d1f
https://doi.org/10.1158/1538-7445.am2023-lb023
https://doi.org/10.1158/1538-7445.am2023-lb023
Autor:
Charles K, Perry, Austen B, Casey, Daniel E, Felsing, Rajender, Vemula, Mehreen, Zaka, Noah B, Herrington, Meng, Cui, Glen E, Kellogg, Clinton E, Canal, Raymond G, Booth
Publikováno v:
Bioorganicmedicinal chemistry. 28(3)
The serotonin 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1e5345e0438fe2f41e5bdc69b8d4543
https://pubmed.ncbi.nlm.nih.gov/31882369
https://pubmed.ncbi.nlm.nih.gov/31882369
Autor:
Raymond G. Booth, Mehreen Zaka, Charles K. Perry, Daniel E. Felsing, Glen E. Kellogg, Meng Cui, Noah B. Herrington, Rajender Vemula, Clinton E. Canal, Austen B. Casey
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115262
The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. We previously reported that a lead an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f14acd52f9611f26364f7fb8193bd0
https://doi.org/10.1016/j.bmc.2019.115262
https://doi.org/10.1016/j.bmc.2019.115262
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 7, p e1012302 (2024)
Protein kinase function and interactions with drugs are controlled in part by the movement of the DFG and ɑC-Helix motifs that are related to the catalytic activity of the kinase. Small molecule ligands elicit therapeutic effects with distinct selec
Externí odkaz:
https://doaj.org/article/0cb357eb62534ecb8b6babdcb88ff44f