Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Noah B, Bloch"'
Autor:
Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Prew et al. uncovered a structural basis for human VLCAD deficiency that arises from point mutations within the enzyme’s membrane-binding region, which was shown to fold as a putative α-helical hairpin. Helix-breaking mutations selectively disrupt
Externí odkaz:
https://doaj.org/article/e862c131a10741b096477d28809d47d0
Autor:
Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The pro-apoptotic BAX protein is a monomer under homeostatic conditions and, in response to stress, transforms into oligomers that induce apoptosis. Here, the authors characterize structural features of BAX that individually stabilize the monomer whi
Externí odkaz:
https://doaj.org/article/6094840e65e043afbdbb1d1b24daacd6
Autor:
David L Cookmeyer, Emily S Winesett, Bashkim Kokona, Adam R Huff, Sabina Aliev, Noah B Bloch, Joshua A Bulos, Irene L Evans, Christian R Fagre, Kerilyn N Godbe, Maryna Khromava, Daniel M Konstantinovsky, Alexander E Lafrance, Alexandra J Lamacki, Robert C Parry, Jeanne M Quinn, Alana M Thurston, Kathleen J S Tsai, Aurelio Mollo, Max J Cryle, Robert Fairman, Louise K Charkoudian
Publikováno v:
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate origina
Externí odkaz:
https://doaj.org/article/16747030f29d460aaae187a6d7c0dcd0
Autor:
Michelle S, Prew, Christina M, Camara, Thomas, Botzanowski, Jamie A, Moroco, Noah B, Bloch, Hannah R, Levy, Hyuk-Soo, Seo, Sirano, Dhe-Paganon, Gregory H, Bird, Henry D, Herce, Micah A, Gygi, Silvia, Escudero, Thomas E, Wales, John R, Engen, Loren D, Walensky
Publikováno v:
Nature communications. 13(1)
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can produce an inborn error of metabolism call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a93e95466fd4e43f2a1609195a31e203
https://pubmed.ncbi.nlm.nih.gov/35760926
https://pubmed.ncbi.nlm.nih.gov/35760926
Autor:
Thomas E. Wales, John R. Engen, Noah B. Bloch, Hannah R. Levy, Michelle S. Prew, Loren D. Walensky
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
BAX is a pro-apoptotic member of the BCL-2 family, which regulates the balance between cellular life and death. During homeostasis, BAX predominantly resides in the cytosol as a latent monomer but, in response to stress, transforms into an oligomeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd7b77a3ae895528bd6f872222670e0
https://doi.org/10.1038/s41467-021-25200-7
https://doi.org/10.1038/s41467-021-25200-7
Publikováno v:
The Journal of Immunology. 198:2943-2956
Mammalian cells have evolved a common DNA damage response (DDR) that sustains cellular function, maintains genomic integrity, and suppresses malignant transformation. In pre-B cells, DNA double-strand breaks (DSBs) induced at Igκ loci by the Rag1/Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d286e766cd71b0786c95b3e4394dfb90
https://doi.org/10.4049/jimmunol.1601639
https://doi.org/10.4049/jimmunol.1601639
Autor:
Joel C. Bucci, Loren D. Walensky, Lixin Fan, Yael Ben-Nun, Danny Cohen, Steven P. Gygi, Liron David, Catherine E. Newman, Scott B. Hansen, Noah B. Bloch, Edward P. Harvey, Zachary J. Hauseman, John R. Engen, Rida Mourtada, Thomas E. Wales, Julian Mintseris, Devin K. Schweppe, Hao Wu, Henry D. Herce
Publikováno v:
Mol Cell
BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b5ff1b6aed8923f699e0b2bd0b9858
https://doi.org/10.1016/j.molcel.2020.05.029
https://doi.org/10.1016/j.molcel.2020.05.029
Publikováno v:
Bioconjugate Chemistry. 26:2360-2370
Activatable fluorophores selective to cytosolic phospholipase A2 (cPLA2) were synthesized and evaluated for their ability to image triple negative breast cancer cells. The activatable constructs were synthesized by esterification of a small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6068a6aae47eeb35c39e17fc01ad4e
https://doi.org/10.1021/acs.bioconjchem.5b00417
https://doi.org/10.1021/acs.bioconjchem.5b00417
Autor:
Kathleen J. S. Tsai, Louise K. Charkoudian, Emily S. Winesett, Sabina Aliev, Alexandra J. Lamacki, Alexander E. Lafrance, Adam R. Huff, David L. Cookmeyer, Joshua A. Bulos, Christian R. Fagre, Maryna Khromava, Kerilyn N. Godbe, Max J. Cryle, Noah B. Bloch, Robert Fairman, Irene L. Evans, Alana M. Thurston, Jeanne M. Quinn, Bashkim Kokona, Robert C. Parry, Aurelio Mollo, Daniel M. Konstantinovsky
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
PLoS Biology, Vol 15, Iss 11, p e2003145 (2017)
How can we provide fertile ground for students to simultaneously explore a breadth of foundational knowledge, develop cross-disciplinary problem-solving skills, gain resiliency, and learn to work as a member of a team? One way is to integrate origina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1eeadede646623c878d93ab0eda6c3
http://europepmc.org/articles/PMC5683658
http://europepmc.org/articles/PMC5683658
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(7)
Mammalian cells have evolved a common DNA damage response (DDR) that sustains cellular function, maintains genomic integrity, and suppresses malignant transformation. In pre-B cells, DNA double strand breaks (DSBs) induced at Igκ loci by the Rag1/Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9aa64d273d1fe470f1061d8f542c227
https://pubmed.ncbi.nlm.nih.gov/28213501
https://pubmed.ncbi.nlm.nih.gov/28213501