Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Noah A, Zaitlen"'
Autor:
Satria P. Sajuthi, Jamie L. Everman, Nathan D. Jackson, Benjamin Saef, Cydney L. Rios, Camille M. Moore, Angel C. Y. Mak, Celeste Eng, Ana Fairbanks–Mahnke, Sandra Salazar, Jennifer Elhawary, Scott Huntsman, Vivian Medina, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Noah A. Zaitlen, Sam Oh, NHLBI Trans–Omics for Precision Medicine (TOPMed) Consortium, José Rodríguez–Santana, Esteban G. Burchard, Max A. Seibold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Externí odkaz:
https://doaj.org/article/2becd8c53e824b738a9f10d4fbec7c85
Autor:
Satria P. Sajuthi, Jamie L. Everman, Nathan D. Jackson, Benjamin Saef, Cydney L. Rios, Camille M. Moore, Angel C. Y. Mak, Celeste Eng, Ana Fairbanks-Mahnke, Sandra Salazar, Jennifer Elhawary, Scott Huntsman, Vivian Medina, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Noah A. Zaitlen, Sam Oh, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, José Rodríguez-Santana, Esteban G. Burchard, Max A. Seibold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Understanding regulation of genes associated to disease can reveal insights into disease mechanisms. Here, the authors perform an airway epithelial transcriptome-wide association analysis to elucidate genetic determinants of airway dysfunction in ast
Externí odkaz:
https://doaj.org/article/f0bfdc317fbf49d288c90aff61c49c7f
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genome-wide association studies (GWAS) are primarily conducted in single-ancestry settings. The low transferability of results has limited our understanding of human genetic architecture across a range of complex traits. In contrast to homogeneous po
Externí odkaz:
https://doaj.org/article/e43a461e045d464ab5f967850958b2e2
Autor:
Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, André M.M. Sousa, Andrew T.N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus Klei, A. Ercument Cicek, Joseph D. Buxbaum, Homa Adle-Biassette, Jean-Leon Thomas, Kimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, Michael E. Talkowski, Kathryn Roeder, Matthew W. State, Bernie Devlin, Stephan J. Sanders, Nenad Sestan
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects through this mechani
Externí odkaz:
https://doaj.org/article/659cb161cbb744e39a67fefdafb36d56
Autor:
Linda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, Jennifer R. Elhawary, Namrata Gupta, Stacey Gabriel, Shujie Xiao, Kevin L. Keys, Akinyemi Oni-Orisan, José R. Rodríguez-Santana, Michael A. LeNoir, Luisa N. Borrell, Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv
Publikováno v:
Nature Genetics.
We explored the role of genetic ancestry in shaping the genetic architecture of whole blood gene expression using whole genome and RNA sequencing data from 2,733 African American and Hispanic/Latino children. We find that heritability of gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d75481c7484dabb2022d2c9eef8a4c
https://doi.org/10.1038/s41588-023-01377-z
https://doi.org/10.1038/s41588-023-01377-z
Autor:
Satria P, Sajuthi, Jamie L, Everman, Nathan D, Jackson, Benjamin, Saef, Cydney L, Rios, Camille M, Moore, Angel C Y, Mak, Celeste, Eng, Ana, Fairbanks-Mahnke, Sandra, Salazar, Jennifer, Elhawary, Scott, Huntsman, Vivian, Medina, Deborah A, Nickerson, Soren, Germer, Michael C, Zody, Gonçalo, Abecasis, Hyun Min, Kang, Kenneth M, Rice, Rajesh, Kumar, Noah A, Zaitlen, Sam, Oh, José, Rodríguez-Santana, Esteban G, Burchard, Max A, Seibold
Publikováno v:
Nature communications. 13(1)
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data. Our airway an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2ca4e62a0423f24b96cee9411910c71
https://pubmed.ncbi.nlm.nih.gov/36192399
https://pubmed.ncbi.nlm.nih.gov/36192399
Autor:
Hyun Min Kang, Jae Hoon Sul, Susan K Service, Noah A Zaitlen, Sit-yee Kong, Nelson B Freimer, Chiara Sabatti, Eleazar Eskin
Publikováno v:
Nature Genetics. 42:348-354
Although genome-wide association studies (GWASs) have identified numerous loci associated with complex traits, imprecise modeling of the genetic relatedness within study samples may cause substantial inflation of test statistics and possibly spurious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514a5a6cf6d6549ce47d85fa289cc2ac
https://doi.org/10.1038/ng.548
https://doi.org/10.1038/ng.548
Autor:
Matti Pirinen, Tuuli Lappalainen, Noah A Zaitlen, GTEx Consortium, Emmanouil T Dermitzakis, Peter Donnelly, Mark I McCarthy, Manuel A Rivas
Motivation: RNA sequencing enables allele specific expression (ASE) studies that complement standard genotype expression studies for common variants and, importantly, also allow measuring the regulatory impact of rare variants. The Genotype-Tissue Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b211a494e6bb652f38349716e454dbb9
https://doi.org/10.1101/007211
https://doi.org/10.1101/007211
