Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Noa B Martín-Cófreces"'
Autor:
Daniel Torralba, Francesc Baixauli, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Ana Latorre-Pellicer, Rebeca Acín-Pérez, Noa B Martín-Cófreces, Ángel Luis Jaso-Tamame, Salvador Iborra, Inmaculada Jorge, Gloria González-Aseguinolaza, Johan Garaude, Miguel Vicente-Manzanares, José Antonio Enríquez, María Mittelbrunn, Francisco Sánchez-Madrid
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can
Externí odkaz:
https://doaj.org/article/0eb2c72dba52481d83ba1541aba39d30
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However, growing evidence shows that their roles on T cell activation are more dynamic than merely serving as tracks or scaffold for dif
Externí odkaz:
https://doaj.org/article/5a7c49aa9017417183b58826ead9136e
Autor:
Rebeca Martínez-Hernández, Ana Serrano-Somavilla, Ana Ramos-Leví, Miguel Sampedro-Nuñez, Alberto Lens-Pardo, José Luis Muñoz De Nova, Juan Carlos Triviño, María Ujue González, Lorena Torné, Javier Casares-Arias, Noa B. Martín-Cófreces, Francisco Sánchez-Madrid, Mónica Marazuela
Publikováno v:
EBioMedicine, Vol 50, Iss , Pp 329-342 (2019)
Background: The mechanisms underlying autoimmune thyroid disease (AITD) remain elusive. Identification of such mechanisms would reveal novel and/or better therapeutic targets. Here, we use integrated analysis of miRNAs and mRNAs expression profiling
Externí odkaz:
https://doaj.org/article/09d67af173a4455ba2be8e98d6bd9d03
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2859 (2020)
The immune synapse (IS) is a well-known intercellular communication platform, organized at the interphase between the antigen presenting cell (APC) and the T cell. After T cell receptor (TCR) stimulation, signaling from plasma membrane proteins and l
Externí odkaz:
https://doaj.org/article/096add112e644386a9202a8ce544f435
Publikováno v:
Biochemical Society Transactions. 49:1735-1748
Tubulin post-translational modifications (PTMs) constitute a source of diversity for microtubule (MT) functions, in addition to the different isotypes of α and β-tubulin acting as building blocks of MTs. Also, MT-associated proteins (MAPs) confer d
Autor:
Álvaro Gómez-Morón, Ilya Tsukalov, Camila Scagnetti, Clara Pertusa, Marta Lozano-Prieto, Pedro Martínez-Fleta, Silvia Requena, Pilar Martín, Aranzazu Alfranca, Enrique Martin-Gayo, Noa B Martin-Cofreces
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCD8+ cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide–MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognat
Externí odkaz:
https://doaj.org/article/0ac181f7f4fc4d9c8e1b085025124003
Publikováno v:
Trends in immunology. 42(8)
T cell asymmetry upon specific cell–cell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for
Publikováno v:
Immunology Letters. 209:11-20
Cell-cell communication comprises a variety of molecular mechanisms that immune cells use to respond appropriately to diverse pathogenic stimuli. T lymphocytes polarize in response to different stimuli, such as cytokines, adhesion to specific ligands
Autor:
Juan Carlos Zabala, A. Rojas-Gomez, S. G. Dosil, Eugenio Bustos-Morán, Francisco Sánchez-Madrid, E. Calvo, Jesús Vázquez, Isabelle Vernos, Juan Antonio López, Noa B. Martín-Cófreces, Francisco Javier Chichón, Joaquín Otón, Daniel Torralba, Elena Bonzón-Kulichenko, Andrea Sorrentino, José M. Valpuesta
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Sci Adv . 2020 Dec 2;6(49):eabb7242.
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Advances
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Sci Adv . 2020 Dec 2;6(49):eabb7242.
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Biblos-e Archivo. Repositorio Institucional de la UAM
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Science Advances
© 2020 The Authors.
T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency
T lymphocyte activation requires the formation of immune synapses (IS) with antigen-presenting cells. The dynamics of membrane receptors, signaling scaffolds, microfilaments, and microtubules at the IS determine the potency
Autor:
Noa B, Martín-Cófreces, Amelia, Rojas-Gomez, Sara G, Dosil, Irene, Fernandez-Delgado, Francisco, Sánchez-Madrid
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2346
The immune synapse (IS) enables cell-cell communication between immune cells through close contacts, as well as T-cell activation and vesicle secretion. It is sustained by fine-tuned molecular interactions of receptors at both cell sides of the IS an