Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Noa, Lamm"'
Autor:
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we ident
Externí odkaz:
https://doaj.org/article/a2cf012d392f4eca877ee8790143a0a5
Autor:
V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
Externí odkaz:
https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0
Publikováno v:
Trends in Cell Biology. 31:843-855
The nucleus is a dynamic environment containing chromatin, membraneless organelles, and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA repair activities are observations of increased mobility of damaged chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffe0d4c271b6032cf4e5c5c53f78952
https://doi.org/10.1016/j.tcb.2021.06.002
https://doi.org/10.1016/j.tcb.2021.06.002
Autor:
Noa Lamm, Karin Maoz, Assaf C Bester, Michael M Im, Donna S Shewach, Rotem Karni, Batsheva Kerem
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1138-1152 (2015)
Abstract Chromosomal instability in early cancer stages is caused by replication stress. One mechanism by which oncogene expression induces replication stress is to drive cell proliferation with insufficient nucleotide levels. Cancer development is d
Externí odkaz:
https://doaj.org/article/3630af744764406695b8cb4f5dfe80c0
SummaryFaithful DNA replication requires the orderly firing of replication origins across the genome. At present, we lack details around how origins are selected for activation and the subsequent impact of this on replication dynamics. Here, we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0a754b5e879b26ad3dead248e866fb9
https://doi.org/10.1101/2022.06.24.497492
https://doi.org/10.1101/2022.06.24.497492
Autor:
Mark Read, V. Pragathi Masamsetti, Paul Timpson, Noa Lamm, Max Nobis, Scott G. Page, Anthony J. Cesare, Maté Biro, David Van Ly
Publikováno v:
Nature Cell Biology. 22:1460-1470
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ee12b977e3291fb8e8724667c143a2
https://doi.org/10.1038/s41556-020-00605-6
https://doi.org/10.1038/s41556-020-00605-6
Autor:
Mike Kareh, Agnel Sfeir, Eros Lazzerini-Denchi, Noa Lamm, Anthony J. Cesare, Alexandra M. Pinzaru
Publikováno v:
Genes Dev
Mutations in the telomere-binding protein POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we define the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1859b4d97d11aa9993dfc3ee312ed9
https://doi.org/10.1101/gad.337287.120
https://doi.org/10.1101/gad.337287.120
Autor:
Noa, Lamm, Mark N, Read, Max, Nobis, David, Van Ly, Scott G, Page, V Pragathi, Masamsetti, Paul, Timpson, Maté, Biro, Anthony J, Cesare
Publikováno v:
Nature cell biology. 22(12)
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here we reveal that nuclear F-actin participates in the replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45682de39a9b02505fd17d1cbbceac78
https://pubmed.ncbi.nlm.nih.gov/33257806
https://pubmed.ncbi.nlm.nih.gov/33257806
Autor:
Agnel Sfeir, Eros Lazzerini-Denchi, Noa Lamm, Mike al-Kareh, Alexandra M. Pinzaru, Anthony J. Cesare
Mutations in the telomere binding protein, POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f919d3739174c9ee1938f81864759b9d
Autor:
Yehuda Tzfati, Noa Lamm, Noa Hourvitz, Aya Awad, Patrick Revy, Riham Smoom, Galina Glousker, Shadi Tawil
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (13), pp.13-7239. ⟨10.1093/nar/gkaa503⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (13), pp.7239-7251. ⟨10.1093/nar/gkaa503⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (13), pp.13-7239. ⟨10.1093/nar/gkaa503⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (13), pp.7239-7251. ⟨10.1093/nar/gkaa503⟩
Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. Telomeres are elongated by telomerase to compensate for incomplete replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca7f81cce08e4775adb078a91b51175
https://hal.archives-ouvertes.fr/hal-02997232
https://hal.archives-ouvertes.fr/hal-02997232