Výsledky vyhledávání - "Noëlle Dufour"

Akademický článek

Huntingtin lowering impairs the maturation and synchronized synaptic activity of human cortical neuronal networks derived from induced pluripotent stem cells

Autor: Mathilde Louçã, Donya El Akrouti, Aude Lemesle, Morgane Louessard, Noëlle Dufour, Chloé Baroin, Aurore de la Fouchardière, Laurent Cotter, Hélène Jean-Jacques, Virginie Redeker, Anselme L. Perrier

Publikováno v: Neurobiology of Disease, Vol 200, Iss , Pp 106630- (2024)

Despite growing descriptions of wild-type Huntingtin (wt-HTT) roles in both adult brain function and, more recently, development, several clinical trials are exploring HTT-lowering approaches that target both wt-HTT and the mutant isoform (mut-HTT) r

Externí odkaz: https://doaj.org/article/014f66c687ef4b789460f73ea00cc84e

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Akademický článek

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)

The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2G2019S are thought to result from an increase in its kinase activity as compared t

Externí odkaz: https://doaj.org/article/f99d8776c12c4a7bb6880f866319890e

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Akademický článek

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells.

Autor: Valérie Drouet, Marta Ruiz, Diana Zala, Maxime Feyeux, Gwennaëlle Auregan, Karine Cambon, Laetitia Troquier, Johann Carpentier, Sophie Aubert, Nicolas Merienne, Fany Bourgois-Rocha, Raymonde Hassig, Maria Rey, Noëlle Dufour, Frédéric Saudou, Anselme L Perrier, Philippe Hantraye, Nicole Déglon

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99341 (2014)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from polyglutamine expansion in the huntingtin (HTT) protein and for which there is no cure. Although suppression of both wild type and mutant HTT expression by R

Externí odkaz: https://doaj.org/article/53fb4717c2244083b8f7184a75b42623

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Akademický článek

Normal aging modulates the neurotoxicity of mutant huntingtin.

Autor: Elsa Diguet, Fanny Petit, Carole Escartin, Karine Cambon, Nicolas Bizat, Noëlle Dufour, Philippe Hantraye, Nicole Déglon, Emmanuel Brouillet

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4637 (2009)

Aging likely plays a role in neurodegenerative disorders. In Huntington's disease (HD), a disorder caused by an abnormal expansion of a polyglutamine tract in the protein huntingtin (Htt), the role of aging is unclear. For a given tract length, the p

Externí odkaz: https://doaj.org/article/05c5333cf7b94ae0824b4acd577e12e4

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Akademický článek

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.

Autor: Sandro Alves, Isabel Nascimento-Ferreira, Gwennaëlle Auregan, Raymonde Hassig, Noëlle Dufour, Emmanuel Brouillet, Maria C Pedroso de Lima, Philippe Hantraye, Luís Pereira de Almeida, Nicole Déglon

Publikováno v: PLoS ONE, Vol 3, Iss 10, p e3341 (2008)

Recent studies have demonstrated that RNAi is a promising approach for treating autosomal dominant disorders. However, discrimination between wild-type and mutant transcripts is essential, to preserve wild-type expression and function. A single nucle

Externí odkaz: https://doaj.org/article/2766a5d9287248fead8a3c51410d315a

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Evidence for a Direct Negative Coupling between Dopamine-D2 Receptors and PLC by Heterotrimeric Gi1/2 Proteins in Rat Anterior Pituitary Cell Membranes

Autor: C. Gerard, Marie-Noëlle Dufour, R. Rasolonjanahary, Alain Enjalbert, Gilles Guillon, Vincent Homburger

Publikováno v: Endocrinology. 143:747-754

Dopamine (DA) is known to inhibit basal and hormone TRH- or angiotensin II (AngII)-stimulated PRL secretion and inositol phosphate accumulation in rat pituitary cells in primary culture. This inhibition persists when cells are incubated in a calcium-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3c2f7e05b62fce0960b4b45d6a84b1
https://doi.org/10.1210/endo.143.3.8697

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Association of the G Proteinαq/α11-Subunit with Cytoskeleton in Adrenal Glomerulosa Cells: Role in Receptor-Effector Coupling1

Autor: Nicole Gallo-Payet, Marie-Noëlle Dufour, Mylène Côté, Marcel D. Payet, Gilles Guillon

Publikováno v: Endocrinology. 138:3299-3307

In 3-day primary cultures of rat glomerulosa cells, a 30-min preincubation with either 10 μm colchicine (a microtubule-disrupting agent) or 10 μm cytochalasin B (a microfilament-disrupting agent) decreased angiotensin II (Ang II)-induced inositol p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::304cbddc1b0ea820b210bcb970c26e93
https://doi.org/10.1210/endo.138.8.5319

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