Hepatitis C virus reveals a novel early control in acute immune response.

Autor: Noëlla Arnaud, Stéphanie Dabo, Daisuke Akazawa, Masayoshi Fukasawa, Fumiko Shinkai-Ouchi, Jacques Hugon, Takaji Wakita, Eliane F Meurs

Publikováno v: PLoS Pathogens, Vol 7, Iss 10, p e1002289 (2011)

Recognition of viral RNA structures by the intracytosolic RNA helicase RIG-I triggers induction of innate immunity. Efficient induction requires RIG-I ubiquitination by the E3 ligase TRIM25, its interaction with the mitochondria-bound MAVS protein, r

Externí odkaz: https://doaj.org/article/42eb46a6ee4545ccbb80de57cfe1f871

Hepatitis C virus reveals a novel early control in acute immune response

Autor: Takaji Wakita, Jacques Hugon, Stéphanie Dabo, Fumiko Shinkai-Ouchi, Masayoshi Fukasawa, Daisuke Akazawa, Noëlla Arnaud, Eliane F. Meurs

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2011, 7 (10), pp.e1002289. ⟨10.1371/journal.ppat.1002289⟩
PLoS Pathogens, Public Library of Science, 2011, 7 (10), pp.e1002289. ⟨10.1371/journal.ppat.1002289⟩
PLoS Pathogens, Vol 7, Iss 10, p e1002289 (2011)

Recognition of viral RNA structures by the intracytosolic RNA helicase RIG-I triggers induction of innate immunity. Efficient induction requires RIG-I ubiquitination by the E3 ligase TRIM25, its interaction with the mitochondria-bound MAVS protein, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82221d58e76c00105e7558705b6a52b3
https://hal-pasteur.archives-ouvertes.fr/pasteur-00635743/document

Hepatitis C Virus Controls Interferon Production through PKR Activation

Autor: Patrick Maillard, Noëlla Arnaud, Penelope Mavromara, Eliane F. Meurs, Jacques Hugon, Agata Budkowska, Stéphanie Dabo, Dominique Garcin, Takaji Wakita, Daisuke Akazawa, Katerina I. Kalliampakou, Anne Gatignol

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2010, 5 (5), pp.e10575. ⟨10.1371/journal.pone.0010575⟩
PLoS ONE, 2010, 5 (5), pp.e10575. ⟨10.1371/journal.pone.0010575⟩
PLOS ONE, Vol. 5, No 5 (2010) P. e10575
PLoS ONE, Vol 5, Iss 5, p e10575 (2010)

International audience; Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4081080380cc91dc04b4c508426582e
https://doi.org/10.1371/journal.pone.0010575