Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Noël J.‐M. Raynal"'
Autor:
Annie Beaudry, Simon Jacques-Ricard, Anaïs Darracq, Nicolas Sgarioto, Araceli Garcia, Teresita Rode García, William Lemieux, Kathie Béland, Elie Haddad, Paulo Cordeiro, Michel Duval, Serge McGraw, Chantal Richer, Maxime Caron, François Marois, Pascal St-Onge, Daniel Sinnett, Xavier Banquy, Noël J.-M. Raynal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor. We urgently need to develop new th
Externí odkaz:
https://doaj.org/article/b621745d7ad44adba530e2248b167729
Autor:
Marie-Lyn Goyer, Cynthia Desaulniers-Langevin, Anthony Sonn, Georgio Mansour Nehmo, Véronique Lisi, Basma Benabdallah, Noël J.-M. Raynal, Christian Beauséjour
Publikováno v:
Cells, Vol 13, Iss 10, p 849 (2024)
The risk of aberrant growth of induced pluripotent stem cell (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Herein, we evaluate the
Externí odkaz:
https://doaj.org/article/b05aeb8b457a46348ea195e1c8cc302c
Autor:
Dina Baier, Theresa Mendrina, Beatrix Schoenhacker‐Alte, Christine Pirker, Thomas Mohr, Mate Rusz, Benedict Regner, Martin Schaier, Nicolas Sgarioto, Noël J.‐M. Raynal, Karin Nowikovsky, Wolfgang M. Schmidt, Petra Heffeter, Samuel M. Meier‐Menches, Gunda Koellensperger, Bernhard K. Keppler, Walter Berger
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract The leading first‐in‐class ruthenium‐complex BOLD‐100 currently undergoes clinical phase‐II anticancer evaluation. Recently, BOLD‐100 is identified as anti‐Warburg compound. The present study shows that also deregulated lipid m
Externí odkaz:
https://doaj.org/article/574893a0a400479184a02dd6ac444ed6
Autor:
Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Flores-Díaz, André Haman, Trang Hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, Noël J.-M. Raynal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Abstract Background Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific c
Externí odkaz:
https://doaj.org/article/bdecc4d44be747e18ba1c9bfae4d8fcf
Autor:
Moutih Rafei, Borhane Annabi, Samaneh Kamyabiazar, Francois Mercier, Maja Jankovic, Jerry Pelletier, Francis Robert, Noël J.-M. Raynal, Annie Beaudry, Hugo Wurtele, Ian Hammond-Martel, Abed El-Hakim El-Kadiry, Nehme El-Hachem, Yun Cui, Jamilah Abusarah
We report the discovery, via a unique high-throughput screening strategy, of a novel bioactive anticancer compound: Thiol Alkylating Compound Inducing Massive Apoptosis (TACIMA)-218. We demonstrate that this molecule engenders apoptotic cell death in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8a046dc9f897f20569dcc72a69be4f
https://doi.org/10.1158/1535-7163.c.6542889
https://doi.org/10.1158/1535-7163.c.6542889
Autor:
Moutih Rafei, Borhane Annabi, Samaneh Kamyabiazar, Francois Mercier, Maja Jankovic, Jerry Pelletier, Francis Robert, Noël J.-M. Raynal, Annie Beaudry, Hugo Wurtele, Ian Hammond-Martel, Abed El-Hakim El-Kadiry, Nehme El-Hachem, Yun Cui, Jamilah Abusarah
Supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0944f56406fdb39605eacf1cde207526
https://doi.org/10.1158/1535-7163.22521048
https://doi.org/10.1158/1535-7163.22521048
Autor:
Jean-Pierre J. Issa, Gabriel G. Malouf, Takahiro Sato, Hanghang Zhang, Saira Ahmed, Vazganush Gharibyan, Justin T. Lee, Elodie M. Da Costa, Noël J.-M. Raynal
Supplementary Fig. S1: Percentage of drugs per drug class among drug libraries used in the HTS; Supplementary Fig. S2: Synergistic GFP reactivation in YB5 cells by HDACi TSA and positive hits identified in the HTS; Supplementary Fig. S3: Optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dce1c4970e7eb45f23d3d77f0b11dc9
https://doi.org/10.1158/1535-7163.22503463.v1
https://doi.org/10.1158/1535-7163.22503463.v1
Autor:
Jean-Pierre J. Issa, Donald L. Gill, Stephen B. Baylin, Ying Cui, Jaroslav Jelinek, Andrew J. Andrews, Ryan A. Henry, Magid Abou-Gharbia, Wayne E. Childers, Woonbok Chung, Saira Ahmed, Vazganush Gharibyan, Elisha J. Dettman, Sarah Dumont, Gabriel G. Malouf, Judith Garriga, Priyanka Madireddi, Annie Beaudry, Youjun Wang, Justin T. Lee, Noël J.-M. Raynal
Table S2. Drug screening results after treatment at 50 µM for 24h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e20fe297d747c2ae370fcf3f0554856
https://doi.org/10.1158/0008-5472.22410422.v1
https://doi.org/10.1158/0008-5472.22410422.v1
Autor:
Nizar M. Tannir, Jaroslav Jelinek, Christopher G. Wood, David Khayat, Jean-Philippe Spano, Roger Mouawad, Frederick Allanick, Pheroze Tamboli, Jose A. Karam, Noël J.-M. Raynal, Yue Lu, Thai H. Ho, Chad J. Creighton, Jianping Zhang, Xiaoping Su, Gabriel G. Malouf
Supplementary Table 3: Ingenuity Pathway Analysis (IPA) for genes which gain promoter DNA methylation in C1 relative to C2 epi-cluster. Supplementary Table 4: Gene Ontology analysis for differentially methylated regions (DMR) between C1 and C2 epi-cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af6880e8c0ca3c1c386ef17b5645354
https://doi.org/10.1158/1078-0432.22460342
https://doi.org/10.1158/1078-0432.22460342
Autor:
Nizar M. Tannir, Jaroslav Jelinek, Christopher G. Wood, David Khayat, Jean-Philippe Spano, Roger Mouawad, Frederick Allanick, Pheroze Tamboli, Jose A. Karam, Noël J.-M. Raynal, Yue Lu, Thai H. Ho, Chad J. Creighton, Jianping Zhang, Xiaoping Su, Gabriel G. Malouf
Unsupervised clustering of DNA methylation using 56 genes epi-signature in an independent data set encompassing 37 renal cell carcinomas cases. C2 contains the majority of oncocytoma and chromophobe RCC cases (n=11/13) as compared to C1 which encompa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173031f8268ae310572e76221107da54
https://doi.org/10.1158/1078-0432.22460360
https://doi.org/10.1158/1078-0432.22460360