Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis

Autor: Marlly Guarin, Annelii Ny, Noémie De Croze, Jan Maes, Marc Léonard, Pieter Annaert, Peter A. M. de Witte

Publikováno v: Pharmaceuticals, Vol 14, Iss 6, p 576 (2021)

Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ZFE is the main route of exposure used, evidence shows that not all small molecules are equally absorbed, possi

Externí odkaz: https://doaj.org/article/f700ab93c9b948f184822ffc20e8e96a

Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases

Autor: Jean-Baptiste Renaud, Charlotte Boix, Marine Charpentier, Anne De Cian, Julien Cochennec, Evelyne Duvernois-Berthet, Loïc Perrouault, Laurent Tesson, Joanne Edouard, Reynald Thinard, Yacine Cherifi, Séverine Menoret, Sandra Fontanière, Noémie de Crozé, Alexandre Fraichard, Frédéric Sohm, Ignacio Anegon, Jean-Paul Concordet, Carine Giovannangeli

Publikováno v: Cell Reports, Vol 14, Iss 9, Pp 2263-2272 (2016)

Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9 nucleases. Precise mutations can be introduced during homology-directed repair with donor DNA carrying the wanted sequence edit, but efficiency is usually lower than for

Externí odkaz: https://doaj.org/article/9e72daf905044cdabb15827d401b0355

ZeBraInspector, a platform for the automated segmentation and analysis of body and brain volumes in whole 5 days post-fertilization zebrafish following simultaneous visualization with identical orientations

Autor: Sylvain Lempereur, Elodie Machado, Fabrice Licata, Matthieu Simion, Lilian Buzer, Isabelle Robineau, Julien Hémon, Payel Banerjee, Noémie De Crozé, Marc Léonard, Pierre Affaticati, Hugues Talbot, Jean-Stéphane Joly

Publikováno v: Developmental Biology
Developmental Biology, 2022, 490, pp.86-99. ⟨10.1016/j.ydbio.2022.07.004⟩

International audience; In recent years, the zebrafish has become a well-established laboratory model. We describe here the ZeBraInspector (ZBI) platform for high-content 3D imaging (HCI) of 5 days post-fertilization zebrafish eleuthero-embryos (EEs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a1ca47cb968fc90dfcad0fc1665905
https://doi.org/10.1016/j.ydbio.2022.07.004

Hairy2–Id3 interactions play an essential role in Xenopus neural crest progenitor specification

Autor: Eric Bellefroid, Xi Ren, Noémie de Crozé, Anne H. Monsoro-Burq, Jacob Souopgui, Massimo Nichane

Publikováno v: Developmental Biology
Developmental Biology, Elsevier, 2008, 322 (2), pp.355-67. ⟨10.1016/j.ydbio.2008.08.003⟩

International audience; Loss of function studies have shown that the Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest formation and maintains cells in a mitotic undifferentiated state. However, its position in the ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c0dbca8ef2dac97cd6de60085417f1

Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network

Autor: Anne H. Monsoro-Burq, Frédérique Maczkowiak, Noémie de Crozé

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (1), pp.155-60. ⟨10.1073/pnas.1010740107⟩

The neural crest (NC) emerges from combinatorial inductive events occurring within its progenitor domain, the neural border (NB). Several transcription factors act early at the NB, but the initiating molecular events remain elusive. Recent data from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c885541172b5fa55e72e34c6f3baa44
https://hal.archives-ouvertes.fr/hal-01183634