Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Noémi Van Hul"'
Autor:
Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš, Emma R Andersson
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2946-2975 (2024)
Abstract Fibrosis contributes to tissue repair, but excessive fibrosis disrupts organ function. Alagille syndrome (ALGS, caused by mutations in JAGGED1) results in liver disease and characteristic fibrosis. Here, we show that Jag1 Ndr/Ndr mice, a mod
Externí odkaz:
https://doaj.org/article/d566732a6e3740f0b6a4cbf98781c57c
Autor:
Franziska Hildebrandt, Miren Urrutia Iturritza, Christian Zwicker, Bavo Vanneste, Noémi Van Hul, Elisa Semle, Jaclyn Quin, Tales Pascini, Sami Saarenpää, Mengxiao He, Emma R. Andersson, Charlotte L. Scott, Joel Vega-Rodriguez, Joakim Lundeberg, Johan Ankarklev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Upon infecting its vertebrate host, the malaria parasite initially invades the liver where it undergoes massive replication, whilst remaining clinically silent. The coordination of host responses across the complex liver tissue during malari
Externí odkaz:
https://doaj.org/article/d1cc34889faf49648e732f73027b9cae
Autor:
Franziska Hildebrandt, Alma Andersson, Sami Saarenpää, Ludvig Larsson, Noémi Van Hul, Sachie Kanatani, Jan Masek, Ewa Ellis, Antonio Barragan, Annelie Mollbrink, Emma R. Andersson, Joakim Lundeberg, Johan Ankarklev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcrip
Externí odkaz:
https://doaj.org/article/086d1b20b6b745fca94bbab34b162566
Autor:
Simona Hankeova, Jakub Salplachta, Tomas Zikmund, Michaela Kavkova, Noémi Van Hul, Adam Brinek, Veronika Smekalova, Jakub Laznovsky, Feven Dawit, Josef Jaros, Vítězslav Bryja, Urban Lendahl, Ewa Ellis, Antal Nemeth, Björn Fischler, Edouard Hannezo, Jozef Kaiser, Emma Rachel Andersson
Publikováno v:
eLife, Vol 10 (2021)
Organ function depends on tissues adopting the correct architecture. However, insights into organ architecture are currently hampered by an absence of standardized quantitative 3D analysis. We aimed to develop a robust technology to visualize, digita
Externí odkaz:
https://doaj.org/article/b15a162506be45549627228691187bdb
Autor:
Ange-Clarisse Dusabineza, Mustapha Najimi, Noémi Van Hul, Vanessa Legry, Dung Ngoc Khuu, Leo A. Van Grunsven, Etienne Sokal, Isabelle A. Leclercq M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 24 (2015)
Human hepatocytes are used for liver cell therapy, but the small number of engrafting cells limits the benefit of cell transplantation. We tested whether cotransplantation of hepatocytes with hepatic stellate cells (HSCs) could improve hepatocyte eng
Externí odkaz:
https://doaj.org/article/186d61e04c1d425c8efcfb1d3bb70ea8
Autor:
Jan Mašek, Iva Filipovic, Simona Hankeová, Jingyan He, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Anna Maria Frontino, Fabio Turetti, Daniel V. Oliveira, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K. Björkström, Martin Gregor, Jan Dobeš, Emma R. Andersson
Background and AimsAlagille syndrome (ALGS) is a pediatric genetic disorder, caused by mutations in the Notch ligandJAGGED1, presenting with cholestasis due to intrahepatic bile duct paucity. Despite chronic liver disease, few patients develop severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc08b5a7d9c962c5cff658d615563084
https://doi.org/10.1101/2022.10.24.513578
https://doi.org/10.1101/2022.10.24.513578
Autor:
Rune Toftgård, Noémi Van Hul, Marco Gerling, Björn Rozell, Carlos Fernández Moro, Inderpreet Sur, Åsa Bergström
Publikováno v:
Transgenic Research
Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296b0b807aad137afadc71bbf45cf953
http://europepmc.org/articles/PMC8478727
http://europepmc.org/articles/PMC8478727
Autor:
Pearlyn Jia Ying Toh, Yue Zhang, Cornelia Monzel, S. Tamir Rashid, Vidhyalakshmi Acharya, Hanry Yu, Virgile Viasnoff, Jasmine Fei Li Chin, Noémi van Hul, Inn Chuan Ng, Richard De Mets, Soon Seng Ng
Publikováno v:
Nature Materials. 19:1026-1035
The symmetry breaking of protein distribution and cytoskeleton organization is an essential aspect for the development of apicobasal polarity. In embryonic cells this process is largely cell autonomous, while differentiated epithelial cells collectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::961ba6831073c3cff3a9943f26987179
https://doi.org/10.1038/s41563-020-0662-3
https://doi.org/10.1038/s41563-020-0662-3
Autor:
Simona Hankeova, Jakub Salplachta, Jozef Kaiser, Michaela Kavkova, Tomáš Zikmund, Afshan Iqbal, Noémi Van Hul, Emma Andersson
Publikováno v:
Journal of visualized experiments : JoVE. 2021, vol. 175, issue e62941, p. 1-19.
The liver is the biggest internal organ in humans and mice, and high auto-fluorescence presents a significant challenge for assessing the three-dimensional (3D) architecture of the organ at the whole-organ level. Liver architecture is characterized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171aa70c8b43d213eba9003e17213dac
https://doi.org/10.3791/62941
https://doi.org/10.3791/62941
Autor:
Franziska Hildebrandt, Sachie Kanatani, Alma Andersson, Jan Masek, Sami Saarenpää, Joakim Lundeberg, Ewa Ellis, Ludvig Larsson, Johan Ankarklev, Annelie Mollbrink, Emma Andersson, Antonio Barragan, Noémi Van Hul
Reconstruction of heterogeneity through single-cell transcriptional profiling has greatly advanced our understanding of the spatial liver transcriptome in recent years. However, global transcriptional differences across lobular units remain elusive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec237fe5a3f63a34dce28acf1fc03883
https://doi.org/10.1101/2021.01.11.426100
https://doi.org/10.1101/2021.01.11.426100