Expression Profiling in Ovarian Cancer Reveals Coordinated Regulation of

Autor: Noélia, Custódio, Rosina, Savisaar, Célia, Carvalho, Pedro, Bak-Gordon, Maria I, Ribeiro, Joana, Tavares, Paula B, Nunes, Ana, Peixoto, Carla, Pinto, Carla, Escudeiro, Manuel R, Teixeira, Maria, Carmo-Fonseca

Publikováno v: Biomedicines. 10(2)

Predictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16d753df6bfab4ecb977f2c99c1d85d5
https://pubmed.ncbi.nlm.nih.gov/35203410

Gene architecture directs splicing outcome in separate nuclear spatial regions

Autor: Luna Tammer, Ofir Hameiri, Ifat Keydar, Vanessa Rachel Roy, Asaf Ashkenazy-Titelman, Noélia Custódio, Itay Sason, Ronna Shayevitch, Victoria Rodríguez-Vaello, José Rino, Galit Lev Maor, Yodfat Leader, Doha Khair, Erez Lieberman Aiden, Ran Elkon, Manuel Irimia, Roded Sharan, Yaron Shav-Tal, Maria Carmo-Fonseca, Gil Ast

Publikováno v: Molecular Cell. 82:1021-1034.e8

How the splicing machinery defines exons or introns as the spliced unit has remained a puzzle for 30 years. Here, we demonstrate that peripheral and central regions of the nucleus harbor genes with two distinct exon-intron GC content architectures th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ed63c2977c9923760199a500ce34b6
https://doi.org/10.1016/j.molcel.2022.02.001

Co-transcriptional splicing and the CTD code

Autor: Maria Carmo-Fonseca, Noélia Custódio

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Critical Reviews in Biochemistry and Molecular Biology

© 2016 Informa UK Limited, trading as Taylor & Francis Group.
Transcription and splicing are fundamental steps in gene expression. These processes have been studied intensively over the past four decades, and very recent findings are challengin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2929120f7e6ddb88010a11d5755e507
https://pubmed.ncbi.nlm.nih.gov/27622638

Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling

Autor: Michael Antoniou, Noélia Custódio, Maria Carmo-Fonseca

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© 2006 Elsevier Inc. All rights reserved.
Eukaryotic RNA polymerase II is a complex enzyme composed of 12 distinct subunits that is present in cells in low abundance. Transcription of mRNA by RNA polymerase II involves a phosphorylation/dephosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95668d36c8dce7d57922fb3d59739b66
https://doi.org/10.1016/j.yexcr.2006.04.018

Inefficient processing impairs release of RNA from the site of transcription

Autor: H S Pereira, Finola Geraghty, Frank Grosveld, Michael Antoniou, Noélia Custódio, Maria Carmo-Fonseca

Publikováno v: EMBO Journal, 18(10), 2855-2866. Wiley-Blackwell

We describe here for the first time the site of retention within the nucleus of pre-mRNA processing mutants unable to be exported to the cytoplasm. Fluorescence in situ hybridization was used to detect transcripts from human beta-globin genes that ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662ce45b677e62f35e1ed2a97a126444
https://doi.org/10.1093/emboj/18.10.2855