Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

Autor: Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández-Tornero

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Cryo-EM structures of Ty1 integrase-Pol III complexes reveal determinants of Ty1 targeting upstream of Pol III-transcribed genes, and a functional impact of the integrase on Pol III activity that may increase the probability of Ty1 integration.

Externí odkaz: https://doaj.org/article/ae5e1040373b42eb93f7571525af5479

A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription

Autor: Amandine Bonnet, Carole Chaput, Noé Palmic, Benoit Palancade, Pascale Lesage

Publikováno v: PLoS Genetics, Vol 17, Iss 11 (2021)

Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes (NPCs) regulate the expression of protein-coding genes. Here, we have implemented transcriptomic and molecular methods to specifically address the impact of the NP

Externí odkaz: https://doaj.org/article/59734d1aa6c5432ca61a92624474d85f

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

Autor: Noé Palmic, Lucile Espert, Joelle Tobaly-Tapiero, Arthur Cormier, Pascale Lesage, Baek Kim, Olivier Schwartz, Felipe Diaz-Griffero, Florence Margottin, Si'Ana A. Coggins, Charlotte Martinat, Alessia Zamborlini, Mirijana Persaud, Ali Saïb, Julian Buchrieser, Guillaume Bossis, Nicoletta Casartelli

SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6a665d4da9bc960c8b3bb65d2e26594
https://doi.org/10.1101/2020.06.04.133439

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

Autor: Jacek Majewski, Mauro Degli Esposti, Capucine Picard, Peter D. Arkwright, Naomi Taylor, Christelle Lenoir, Jeremy Schwartzentruber, Sylvain Latour, Emmanuel Martin, Robert Wynn, Fabian Hauck, Patrick Nitschké, Noé Palmic, Sylvia Sanquer, Alain Fischer, Cédric Mongellaz, Nada Jabado, Sylvie Fabrega

Publikováno v: Nature
Nature, 2014, 510 (7504), pp.288--92. ⟨10.1038/nature13386⟩
Nature, Nature Publishing Group, 2014, 510 (7504), pp.288--92. ⟨10.1038/nature13386 nature13386 [pii]⟩
Nature, Nature Publishing Group, 2014, 510 (7504), pp.288--92. ⟨10.1038/nature13386⟩

International audience; Lymphocyte functions triggered by antigen recognition and co-stimulation signals are associated with a rapid and intense cell division, and hence with metabolism adaptation. The nucleotide cytidine 5' triphosphate (CTP) is a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9ac0fb289f4c7587fd4385da912c27
https://hal.science/hal-02191580

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration.

Autor: Nguyen, Phong Quoc, Huecas, Sonia, Asif-Laidin, Amna, Plaza-Pegueroles, Adrián, Capuzzi, Beatrice, Palmic, Noé, Conesa, Christine, Acker, Joël, Reguera, Juan, Lesage, Pascale, Fernández-Tornero, Carlos

Publikováno v: Nature Communications; 3/28/2023, Vol. 14 Issue 1, p1-13, 13p