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Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.

Autor: Amor C; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA., Fernández-Maestre I; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chowdhury S; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA., Ho YJ; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nadella S; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA., Graham C; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Carrasco SE; Laboratory of Comparative Pathology. Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, and Rockefeller University, New York, NY, USA., Nnuji-John E; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA.; Cold Spring Harbor School of Biological Sciences, Cold Spring Harbor, NY, USA., Feucht J; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Cluster of Excellence iFIT, University Children's Hospital Tuebingen, Tuebingen, Germany., Hinterleitner C; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Barthet VJA; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Boyer JA; Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, USA., Mezzadra R; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wereski MG; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tuveson DA; Cold Spring Harbor Laboratory. Cold Spring Harbor, NY, USA., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Jones LW; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Sadelain M; Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lowe SW; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, USA.

Publikováno v: Research square [Res Sq] 2023 Sep 26. Date of Electronic Publication: 2023 Sep 26.