Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nne E. Uko"'
Publikováno v:
Current Topics in Medicinal Chemistry. 20:883-900
Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development, and the identification of new targets, the war on cancer was launched, in 1972. The P13K/Akt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69992ed5d7f1c07ef5636eedfc1a68da
https://doi.org/10.2174/1568026620666200224101808
https://doi.org/10.2174/1568026620666200224101808
Publikováno v:
Anticancer Research. 39:5329-5338
Background/aim The P13K/Akt signaling pathway is a growth-regulating cellular pathway that is constitutively activated in a variety of human cancers. In previous studies, we reported that a solenopsin analog, compound B (MU-06-SC-608-7), shows inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d133497aa083c3afc5d49e8e7d37d40f
https://doi.org/10.21873/anticanres.13725
https://doi.org/10.21873/anticanres.13725
Publikováno v:
Investigational New Drugs. 37:902-911
Chaetoglobosin K (ChK) is a natural product that has been shown to promote F-actin capping, inhibit growth, arrest cell cycle G2 phase, and induce apoptosis. ChK also has been shown to downregulate two important kinases involved in oncogenic pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e478f6a4905ffa145a2c5f014495e930
https://doi.org/10.1007/s10637-018-0705-7
https://doi.org/10.1007/s10637-018-0705-7
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(19)
The P13K/Akt pathway is a growth-regulating cellular signaling pathway that is over-activated in numerous human cancers. A novel series of Akt pathway inhibitors were identified using iterative pharmacophore modeling, energy-based calculations, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfb066dca0592520939fb57c3ce704e
https://pubmed.ncbi.nlm.nih.gov/30143420
https://pubmed.ncbi.nlm.nih.gov/30143420