Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nnamdi Ihuegbu"'
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated colorectal cancer tumors, however, its relationship with treatment response remains to be explored. Here, the authors suggest that ARID1A mutations may confer intrinsic
Externí odkaz:
https://doaj.org/article/4488b89ca7bf43bdb1d09041a86d2a0c
Autor:
Radia M. Johnson, Xueping Qu, Chu-Fang Lin, Ling-Yuh Huw, Avinashnarayan Venkatanarayan, Ethan Sokol, Fang-Shu Ou, Nnamdi Ihuegbu, Oliver A. Zill, Omar Kabbarah, Lisa Wang, Richard Bourgon, Felipe de Sousa e Melo, Chris Bolen, Anneleen Daemen, Alan P. Venook, Federico Innocenti, Heinz-Josef Lenz, Carlos Bais
Publikováno v:
Nature communications. 13(1)
Most colorectal (CRC) tumors are dependent on EGFR/KRAS/BRAF/MAPK signaling activation. ARID1A is an epigenetic regulator mutated in approximately 5% of non-hypermutated CRC tumors. Here we show that anti-EGFR but not anti-VEGF treatment enriches for
Autor:
Xueping Qu, Felipe De Sousa E Melo, Ling-Yuh Huw, Richard Bourgon, Joshua Thomas, Nnamdi Ihuegbu, Anneleen Daemen, Heinz-Josef Lenz, Radia M. Johnson, Fang-Shu Ou, Omar Kabbarah, Alan Venook, Ethan Sokol, Oliver A. Zill, Carlos Bais, Yvonne Kschonsak, Federico Innocenti
Publikováno v:
Cancer Research. 80:LB-063
Extensive biological and clinical evidence supports the notion many CRC tumors are addicted to EGFR/KRAS/MAPK signaling. For example, mutations in KRAS, BRAF and other MAPK pathway components confer intrinsic or acquired resistance to anti-EGFR thera
Autor:
Amanda C. Wollenberg, Anna-Maria F. Alves, Lyly G. Luhachack, Gary D. Stormo, Lynda M. Stuart, Javier E. Irazoqui, Orane Visvikis, Sid Ahmed Labed, Nnamdi Ihuegbu
Publikováno v:
Immunity. 40(6):896-909
SummaryAnimal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation of the transcription factors involved. By using an
Publikováno v:
G3: Genes|Genomes|Genetics
Transcriptional regulation, a primary mechanism for controlling the development of multicellular organisms, is carried out by transcription factors (TFs) that recognize and bind to their cognate binding sites. In Caenorhabditis elegans, our knowledge
Autor:
Richard B. Lanman, Kimberly C. Banks, Joseph Diaz, Robert C. Doebele, Collin M. Blakely, Nnamdi Ihuegbu
Publikováno v:
Journal of Thoracic Oncology. 12:S522
Autor:
Nnamdi Ihuegbu, Darya Chudova, Stephen R. Fairclough, Kimberly C. Banks, Collin M. Blakely, Oliver A. Zill, Richard B. Lanman
Publikováno v:
Journal of Clinical Oncology. 34:e20643-e20643
e20643Background: Somatic mutations (SNVs) in ALK are a common mechanism of resistance to crizotinib, and may respond to next-generation ALK inhibitors. Historically, identification of these ALK SN...
Regulatory sites that control gene expression are essential to the proper functioning of cells, and identifying them is critical for modeling regulatory networks. We have developed Magma (Multiple Aligner of Genomic Multiple Alignments), a software t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a593d5b90ab311b55b06c98b9037266
https://europepmc.org/articles/PMC3272693/
https://europepmc.org/articles/PMC3272693/
Autor:
Sharon Wootton, William C. Speed, J. Chang, A.J. Pakstis, Kenneth K. Kidd, Nnamdi Ihuegbu, Robert Lagacé
Publikováno v:
Forensic Science International: Genetics Supplement Series. 4:e123-e124
Modern sequencing technology makes it possible to genotype polymorphisms with high throughput and high multiplexing. We have searched for and identified many loci with 2 or more SNPs within the expanse of a 200bp single sequence run and show that whe