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Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.

Autor: Moghadasi SA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA, 55455., Heilmann E; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Khalil AM; Texas Biomedical Research Institute, San Antonio, Texas, USA, 78227.; Department of Zoonotic Diseases, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511., Nnabuife C; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA, 77030., Kearns FL; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA, 92093., Ye C; Texas Biomedical Research Institute, San Antonio, Texas, USA, 78227., Moraes SN; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA, 55455., Costacurta F; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Esler MA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA, 55455., Aihara H; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA, 55455., von Laer D; Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, Texas, USA, 78227., Palzkill T; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA, 77030., Amaro RE; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA, 92093., Harris RS; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA, 55455.; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio; San Antonio, Texas, USA, 78229.; Howard Hughes Medical Institute, University of Texas Health San Antonio; San Antonio, Texas, USA, 78229.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Dec 26. Date of Electronic Publication: 2022 Dec 26.