Zobrazeno 1 - 10
of 22 956
pro vyhledávání: '"Nlrp3 inflammasome"'
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract The NLRP3 inflammasome plays a crucial role in inflammatory responses, particularly in alcohol-related liver disease (ALD). Given that NLRP3 has emerged as a potential therapeutic target for ALD, the development of effective inhibitors is of
Externí odkaz:
https://doaj.org/article/59353c9fb0bd46b3a52e72062e78f182
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Chronic inflammation and NLRP3 inflammasome activation are among the determining factors of breast malignancies. Paclitaxel (PTX) is a drug used in breast cancer treatment which sustains prolonged inflammation, reducing the effectiveness of
Externí odkaz:
https://doaj.org/article/7cea1cd7940a44d3ad68974f26a90af6
Autor:
Chenyang Liu, Qun Zhang, Hong Zhou, Linling Jin, Chang Liu, Mingxia Yang, Xinyun Zhao, Wenqiu Ding, Weiping Xie, Hui Kong
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exerts antifibrotic effect
Externí odkaz:
https://doaj.org/article/cf5a36068247478eb83c87e47a109837
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Systemic inflammation contributes to left ventricular (LV) dysfunction, however the role of the NLRP3 inflammasome in LV dysfunction in acute inflammatory conditions is unclear. This study investigated the role of the NLRP3 inflammasome in a
Externí odkaz:
https://doaj.org/article/772cd8b4117d48b5bdada554dd1809ff
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract The NLR family pyrin domain containing 3 (NLRP3) inflammasome in microglia is intimately linked to the pathogenesis of Alzheimer’s disease (AD). Although NLRP3 inflammasome activity is regulated by cellular metabolism, the underlying mecha
Externí odkaz:
https://doaj.org/article/2b24c9de1ee44983845093f3650aa94c
Autor:
Dingyu Chen, Lixia Wu, Xi Liu, Qinrong Wang, Shuqin Gui, Liya Bao, Zhengrong Wang, Xiaofeng He, Yan Zhao, Jianjiang Zhou, Yuan Xie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Helicobacter pylori (H. pylori) is one of the most common bacterial infections in the world, and its key virulence component CagA is the leading cause of gastric cancer. Mitophagy is a form of selective autophagy that eliminates damaged mito
Externí odkaz:
https://doaj.org/article/23ee2ebbd22b4708a0522555ea8700e9
Autor:
Congshu Huang, Chaoji Huangfu, Zhijie Bai, Long Zhu, Pan Shen, Ningning Wang, Gaofu Li, Huifang Deng, Zengchun Ma, Wei Zhou, Yue Gao
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Radiation-induced skin injury is a significant adverse reaction to radiotherapy. However, there is a lack of effective prevention and treatment methods for this complication. Ferulic acid (FA) has been identified as an effective a
Externí odkaz:
https://doaj.org/article/a5ced6cadb8646e3b41d7786004727bb
Autor:
Xin Shen, Jinrong Ran, Qingqing Yang, Bingjie Li, Yi Lu, Jiajia Zheng, Liuyi Xu, Kaixiang Jia, Zhiwei Li, Lianci Peng, Rendong Fang
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-13 (2024)
Abstract Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that induces an NLRP3-dependent cytokine storm. NLRP3 inflammasome activation triggers not only an inflammatory response but also pyroptosis. However, the exact mechanism
Externí odkaz:
https://doaj.org/article/be7856ba16f84b4391638b12535d4c61
Autor:
Yanan Guo, Jiayi Liu, Xingyue Du, Mian Qi, Tongping She, Ke Xue, Xinhe Wu, Lihua Xu, Bin Peng, Yunfeng Zhang, Yufeng Liu, Zhenglin Jiang, Xia Li, Yuan Yuan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Acute ischemic stroke (AIS) is a major global health concern due to its high mortality and disability rates. Hemorrhagic transformation, a common complication of AIS, leads to poor prognosis yet lacks effective treatments. Preclinical studie
Externí odkaz:
https://doaj.org/article/c36c988b33f84730be1b1e711a5fcb48
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 6277-6295 (2024)
Ranran Lu,1,2,* Xu Zhou,1,2,* Lijie Zhang,3 Mengdie Hao,1,2 Xinling Yang1,4 1Department of Neurology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, People’s Republic of China; 2Xinjiang Key Laboratory of
Externí odkaz:
https://doaj.org/article/3fc5899e99154d1daf2e55fcbb5ad4b9