Zobrazeno 1 - 10
of 1 445
pro vyhledávání: '"Nlrc4"'
Autor:
Kosar Asna Ashari, Nima Parvaneh, Kayvan Mirnia, Mehri Ayati, Maryam Saeedi, Farhad Salehzadeh, Mohammad Shahrooei, Razieh Sangsari, Pejman Rohani, Vahid Ziaee
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-7 (2024)
Abstract Background Gain of function (GOF) mutations in NOD-like receptor family CARD-containing 4 protein (NLRC4) gene induce a wide spectrum of autoinflammatory phenotypes. Currently, we categorize them into four groups: familial cold autoinflammat
Externí odkaz:
https://doaj.org/article/028afa411aba48dba285ddbd43f4f0f5
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT This study explores the effects of disinfectant and antibiotic exposure on gut health, focusing on gut microbiota balance and gut immune function. Our analysis indicates that disinfectants increase the proportion of Gram-positive bacteria, p
Externí odkaz:
https://doaj.org/article/a1af42fd1f8e43fb9fe44ea79587b54d
Autor:
Beirong Yu, Bangxu Zheng, Yu Shen, Yijing Shen, Haiyan Qiu, Ling Wu, Yuanling Chen, Xiaohong Cai, Junhua Wu, Qingxiao Hong
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD
Externí odkaz:
https://doaj.org/article/5adb74596f464f059e9fdb26430defde
Autor:
O. P. Lebedeva, V. M. Ivannikova, I. O. Zhukova, O. N. Kozarenko, O. B. Altukhova, S. P. Pakhomov, M. I. Churnosov
Publikováno v:
Акушерство, гинекология и репродукция, Vol 17, Iss 5, Pp 554-564 (2023)
Nucleotide-binding oligomerization domain-like receptors (NOD-like receptors) are cytosolic signaling receptors of innate immune cells recognizing ligands derived from bacteria, viruses, fungi and protozoa. They can initiate apoptosis and pro-inflamm
Externí odkaz:
https://doaj.org/article/d9cc7834f6eb474fad72e75dc3ba312c
Publikováno v:
BMC Rheumatology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Background The inflammasome plays an important role in rheumatoid arthritis (RA), which has rarely been systematically reported. The aim of this study was to understand whether the levels of inflammasomes were related to the severity of RA d
Externí odkaz:
https://doaj.org/article/d5d65921816148bcad69f017b36a62b5
Autor:
Teng Zhang, Yong Zhou, Yan Zhang, De-Guo Wang, Qiu-Yue Lv, Wen Wang, Ya-Ping Bai, Qiang Hua, Li-Qun Guo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Sesamin (Ses) is a natural lignan abundantly present in sesame and sesame oil. Pyroptosis, a newly identified type of pro-inflammatory programmed necrosis, contributes to the development of non-alcoholic steatohepatitis (NASH) when hepatocyte pyropto
Externí odkaz:
https://doaj.org/article/d8f9e6dd328a4b58bb43a00250ec1dce
Autor:
Elien Eeckhout, Tomoko Asaoka, Hanne Van Gorp, Dieter Demon, Charlotte Girard-Guyonvarc’h, Vanessa Andries, Lars Vereecke, Cem Gabay, Mohamed Lamkanfi, Geert van Loo, Andy Wullaert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAutoinflammation with infantile enterocolitis (AIFEC) is an often fatal disease caused by gain-of-function mutations in the NLRC4 inflammasome. This inflammasomopathy is characterized by macrophage activation syndrome (MAS)-like episodes as
Externí odkaz:
https://doaj.org/article/22257ef24119463f84ae7fbc3bf11db2
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Inflammasomes are a group of protein complex located in cytoplasm and assemble in response to a wide variety of pathogen‐associated molecule patterns, damage‐associated molecule patterns, and cellular stress. Generally, the activation of
Externí odkaz:
https://doaj.org/article/317a49f39efb4ce494217b9ddd08a1a9
Publikováno v:
Indian Journal of Dermatology, Vol 68, Iss 4, Pp 385-392 (2023)
Background: Activation of the NLRC4 inflammasome appears to start many signalling processes inside the host, including caspase-1, the principal protease responsible for converting proIL-1β and IL-18 to active, secreted IL-1β and IL-18, resulting in
Externí odkaz:
https://doaj.org/article/71838df98bd1474facc04cb2ede0e02e
Autor:
Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomo
Externí odkaz:
https://doaj.org/article/8ebc97ff867d42c99a352b940efac384