'Kuteteza': A community-engaged COVID-19 Prevention and Protection Initiative in Southern Malawi [version 2; peer review: 2 approved]

Autor: Mwiza Sambo, Donnie Mategula, Latif Ndeketa, Clara Sambani, Wisdom Shonga, Steve Vinkhumbo, Titus Divala, Robert Mataya, Melody Sakala, Dominic Nkhoma, Sepeedeh Saleh, Wongani Nyangulugu, Ana Ibarz-Pavón, Henry Sambakunsi, Mphatso D. Phiri, Marlen Chawani

Publikováno v: Wellcome Open Research, Vol 9 (2024)

Background The COVID-19 epidemic in Malawi involved almost 90,000 recorded cases and 2,638 deaths. In response to early concerns about vulnerable older people in rural areas, we developed ‘Kuteteza’: a COVID-19 mitigation response project. Clinic

Externí odkaz: https://doaj.org/article/2272bd0429f04ad1b7c6b754bb1f7422

Experimental Human Pneumococcal Carriage using Streptococcus pneumoniae serotype 3 in Malawi: a dose ranging and reproducibility human infection study [version 1; peer review: 2 approved, 1 approved with reservations]

Autor: Clara Ngoliwa, Kondwani Jambo, Neema Toto, Vitumbiko S. Nkhoma, Lorensio Chimgoneko, Marc Henrion, Lumbani Makhaza, John Ndaferankhande, Stephen B. Gordon, Gift Chiwala, Gareth Lipunga, Anthony Emeritus Chirwa, Bridgette Galafa, Faith Thole, Evarista Kudowa, Morrison Peace Kamanga, Godwin Tembo, Dingase Dula, Daniela M. Ferreira, Tarsizio Chikaonda, Ndaziona Peter Kwanjo Banda, Edna Nsomba

Publikováno v: Wellcome Open Research, Vol 9 (2024)

Background Streptococcus pneumoniae is a major cause of morbidity and mortality from respiratory tract infections, pneumonia, meningitis, and sepsis. Nasopharyngeal carriage of pneumococcus is a prerequisite for pneumococcal disease and transmission.

Externí odkaz: https://doaj.org/article/c01b3e2b0cc342a49260484f2f7a941c

A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance

Autor: John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely Brenneman, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann Reyes, Rupam Tripura, Thomas J. Peto, Dysoley Lek, Angana Mukherjee, Stefan H. I. Kappe, Mehul Dhorda, Standwell C. Nkhoma, Ian H. Cheeseman, Ashley M. Vaughan, Timothy J. C. Anderson, Michael T. Ferdig

Publikováno v: mBio, Vol 15, Iss 7 (2024)

ABSTRACT Piperaquine (PPQ) is widely used in combination with dihydroartemisinin as a first-line treatment against malaria. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine re

Externí odkaz: https://doaj.org/article/b191e5641f084dea867745f9b4a6c1b8

Association of migration and family planning use among women in Malawi: Evidence from 2019/2020 Malawi Multiple Indicators Survey

Autor: Reuben Christopher Moyo, Dumisani Nkhoma

Publikováno v: Contraception and Reproductive Medicine, Vol 8, Iss 1, Pp 1-10 (2023)

Abstract Background Family planning (FP) is known to bring multiple benefits to people both individually and collectively. Individually, FP has been associated with reduction in risk of unintended pregnancy which also correlates with low child mortal

Externí odkaz: https://doaj.org/article/c7b8dfdb04e746bab9d7f95732642b25

Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)Research in context

Autor: Nicholas I. Paton, Wolfgang Stöhr, Alejandro Arenas-Pinto, Amanda Clarke, Ian Williams, Margaret Johnson, Chloe Orkin, Fabian Chen, Vincent Lee, Alan Winston, Mark Gompels, Julie Fox, Karen Sanders, David T. Dunn, Martin Fisher, Wendy Hadley, David Stacey, Pat Byrne, Nahum De Esteban, Pierre Pellegrino, Lewis Haddow, James Hand, Carl De Souza, Lisa Murthen, Andrew Crawford-Jones, Ruth Wilson, Elizabeth Green, John Masterson, Kamlesh Patel, Rebecca Howe, Scott Mullaney, Louise Jennings, Nicholas Beeching, Rebecca Tamaklo, Alistair Teague, Isabelle Jendrulek, Juan Manuel Tiraboschi, Ed Wilkins, Yvonne Clowes, Andrew Thompson, Gary Brook, Manoj Trivedi, Kazeem Aderogba, Martin Jones, Andrew DeBurgh-Thomas, Liz Jones, Iain Reeves, Sifiso Mguni, David Chadwick, Pauline Spence, Nellie Nkhoma, Zoe Warwick, Suzanne Price, Sally Read, Elbushra Herieka, James Walker, Ruth Woodward, John Day, Laura Hilton, Veerakathy Harinda, Helen Blackman, Phillip Hay, Wendy Mejewska, Olanike Okolo, Edmund Ong, Karen Martin, Lee Munro, David Dockrell, Lynne Smart, Jonathan Ainsworth, Anele Waters, Stephen Kegg, Sara McNamara, Steve Taylor, Gerry Gilleran, Brian Gazzard, Jane Rowlands, Sris Allan, Rumun Sandhu, Nigel O'Farrell, Sheena Quaid, Fabiola Martin, Caroline Bennett, Moses Kapembwa, Jane Minton, James Calderwood, Frank Post, Lucy Campbell, Emily Wandolo, Adrian Palfreeman, Linda Mashonganyika, Thambiah Balachandran, Memory Kakowa, Rebecca O'Connell, Cheryl Tanawa, Sinna Jebakumar, Lesley Hagger, Say Quah, Sinead McKernan, Charles Lacey, Sarah Douglas, Sarah Russell-Sharpe, Christine Brewer, Clifford Leen, Sheila Morris, Sharmin Obeyesekera, Shirley Williams, Nelson David, Mark Roberts, Julie Wollaston, Nicholas Paton, Karen Scott, David Dunn, Emma Beaumont, Sue Fleck, Mark Hall, Susie Hennings, Ischa Kummeling, Sara Martins, Ellen Owen-Powell, Fionna van Hooff, Livia Vivas, Ellen White, Brian Angus, Andrew Freedman, Ben Cromerty, Danielle Mercey, Sarah Fidler, Estee Torok, Abdel Babiker, Tim Peto, David Lalloo, Andrew Phillips, Robert James

Publikováno v: EClinicalMedicine, Vol 69, Iss , Pp 102457- (2024)

Summary: Background: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy. Methods: Eligible participants attending 43 UK treatment centres had a

Externí odkaz: https://doaj.org/article/aefd2413e78d42f29d03d4ab013c1e5b