Cytotoxic activity of crude extracts from Datura stramonium’s fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling

Autor: Kudzanai Ian Tapfuma, Nkemdinma Uche-Okereafor, Tendani Edith Sebola, Raeesa Hussan, Lukhanyo Mekuto, Maya Mellisa Makatini, Ezekiel Green, Vuyo Mavumengwana

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Endophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. In this study, crude extracts from fungal endophytes isolated from Datura stramonium were evaluated

Externí odkaz: https://doaj.org/article/980ca4756e2848d98a5c31b4ec2291c9

Cytotoxic activity of crude extracts from Datura stramonium’s fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling

Autor: Raeesa Hussan, Nkemdinma Uche-Okereafor, Maya M. Makatini, Vuyo Mavumengwana, Tendani Edith Sebola, Kudzanai Ian Tapfuma, Ezekiel Green, Lukhanyo Mekuto

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Complementary and Alternative Medicine

BackgroundEndophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. In this study, crude extracts from fungal endophytes isolated fromDatura stramoniumwere evaluated for cytotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a8ad5019d8753760d19ac9b1508098
http://link.springer.com/article/10.1186/s12906-019-2752-9

Anticancer activity and metabolite profiling data of Penicillium janthinellum KTMT5

Autor: Kudzanai Ian Tapfuma, Lukhanyo Mekuto, Raeesa Hussan, Nkemdinma Uche-Okereafor, Jody Koopman, Tendani Edith Sebola, Maya M. Makatini, Vuyo Mavumengwana

Publikováno v: Data in Brief

Fungi are ubiquitous, they proliferate even in environments with toxic pollutants that are otherwise harmful to other eukaryotes. This article presents data of fungi which were isolated from gold mine tailings and identified by DNA sequencing of thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7691c88e10de09c3f1cc2184910e674f
http://europepmc.org/articles/PMC6928313

Antibacterial Activities of Crude Secondary Metabolite Extracts from Pantoea Species Obtained from the Stem of Solanum mauritianum and Their Effects on Two Cancer Cell Lines

Autor: Lukhanyo Mekuto, Nkemdinma Uche-Okereafor, Tendani Edith Sebola, Kudzanai Ian Tapfuma, Ezekiel Green, Vuyo Mavumengwana

Publikováno v: International Journal of Environmental Research and Public Health, Vol 16, Iss 4, p 602 (2019)
International Journal of Environmental Research and Public Health
Volume 16
Issue 4

Endophytes are microorganisms that are perceived as non-pathogenic symbionts found inside plants since they cause no symptoms of disease on the host plant. Soil conditions and geography among other factors contribute to the type(s) of endophytes isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faa3f5a20fd66926148e6e4df4a8721
https://www.mdpi.com/1660-4601/16/4/602

MOESM2 of Cytotoxic activity of crude extracts from Datura stramonium’s fungal endophytes against A549 lung carcinoma and UMG87 glioblastoma cell lines and LC-QTOF-MS/MS based metabolite profiling

Autor: Kudzanai Tapfuma, Nkemdinma Uche-Okereafor, Tendani Sebola, Raeesa Hussan, Lukhanyo Mekuto, Makatini, Maya, Green, Ezekiel, Vuyo Mavumengwana

Additional file 2. LC-QTOF-MS-MS_Analysis. Mass spectra for the crude extract of Alternaria sp. KTDL7 and the mass fragment patterns of the identified compounds: 1,8-dihydroxynaphthalene (1), anserinone B (2), phelligridin B (3), metacytofilin (4), p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987eef060f415e80308304e771863099