Five endometrial cancer risk loci identified through genome-wide association analysis

Autor: Cheng, THT, Thompson, DJ, O'Mara, TA, Painter, JN, Glubb, DM, Flach, S, Lewis, A, French, JD, Freeman-Mills, L, Church, D, Gorman, M, Martin, L, National Study of Endometrial Cancer Genetics Group (NSECG), Hodgson, S, Webb, PM, Australian National Endometrial Cancer Study Group (ANECS), Attia, J, Holliday, EG, McEvoy, M, Scott, RJ, Henders, AK, Martin, NG, Montgomery, GW, Nyholt, DR, Ahmed, S, Healey, CS, Shah, M, Dennis, J, Fasching, PA, Beckmann, MW, Hein, A, Ekici, AB, Hall, P, Czene, K, Darabi, H, Li, J, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, I, Amant, F, Schrauwen, S, Zhao, H, Lambrechts, D, Depreeuw, J, Dowdy, SC, Goode, EL, Fridley, BL, Winham, SJ, Njølstad, TS, Salvesen, HB, Trovik, J, Werner, HMJ, Ashton, K, Otton, G, Proietto, T, Liu, T, Mints, M, Tham, E, RENDOCAS, CHIBCHA Consortium, Li, MJ, Yip, SH, Wang, J, Bolla, MK, Michailidou, K, Wang, Q, Tyrer, JP, Dunlop, M, Houlston, R, Palles, C, Hopper, JL, AOCS Group, Peto, J, Swerdlow, AJ, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, FJ, Giles, GG, Kristensen, VN, Cox, A, Cunningham, JM, Pharoah, PDP, Dunning, AM, Edwards, SL, Easton, DF, Tomlinson, I, Spurdle, AB

Publikováno v: Nature Genetics

We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::adc9037f5b68ccd4fb6d96ab697f2376
https://researchonline.lshtm.ac.uk/id/eprint/2551460/1/Cheng_etal_2016_Five_endometrial_cancer_risk_loci_identified_through_genome_wide_association_analysis.pdf

Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer.

Autor: Hveem TS; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway., Njølstad TS; KG Jebsen Center for Gynecologic Cancer Research, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Nielsen B; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Syvertsen RA; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Nesheim JA; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Kjæreng ML; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Kildal W; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Pradhan M; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway., Marcickiewicz J; Department of Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Obstetrics and Gynecology, Halland's Hospital Varberg, Varberg, Sweden., Tingulstad S; Department of Gynecology, St. Olav's Hospital, Trondheim, Norway., Staff AC; Department of Gynecology, Oslo University Hospital, Ullevål, Oslo, Norway., Haugland HK; Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway., Eraker R; Department of Obstetrics and Gynecology, Akershus University Hospital, Lørenskog, Norway.; University of Oslo, Oslo, Norway., Oddenes K; Department of Obstetrics and Gynecology, Haugesund Hospital, Haugesund, Norway., Rokne JA; Department of Obstetrics and Gynecology, Hospital of Vestfold, Tønsberg, Norway., Tjugum J; Department of Obstetrics and Gynecology, Førde Hospital, Førde, Norway., Lode MS; Department of Obstetrics and Gynecology, Ålesund Hospital, Ålesund, Norway., Amant F; Department of Gynecologic Oncology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium., Werner HM; KG Jebsen Center for Gynecologic Cancer Research, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Bjørge L, Albregtsen F; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway., Liestøl K; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway., Salvesen HB; KG Jebsen Center for Gynecologic Cancer Research, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Trovik J; KG Jebsen Center for Gynecologic Cancer Research, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Danielsen HE; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway. hdaniels@labmed.uio.no.; Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway.; Department of Informatics, University of Oslo, Oslo, Norway.; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom.

Publikováno v: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2017 Jan; Vol. 26 (1), pp. 61-67. Date of Electronic Publication: 2016 Sep 01.

[Hemorrhagia neonatorum probably maternorum?].

Autor: Njølstad TS; Barne- og ungdomsavdelinga Ålesund sjukehus., Sivertsen W; Barne- og ungdomsavdelinga Ålesund sjukehus., Gülpen FR; Barne- og ungdomsavdelinga Ålesund sjukehus., Eriksen BH; Barne- og ungdomsavdelinga Ålesund sjukehus.

Publikováno v: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2016 Oct 11; Vol. 136 (18), pp. 1548. Date of Electronic Publication: 2016 Oct 11 (Print Publication: 2016).

Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.

Autor: O'Mara TA; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Glubb DM; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Painter JN; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Cheng T; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Dennis J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Attia J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Holliday EG; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, McEvoy M; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Scott RJ; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Ashton K; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Proietto T; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Otton G; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Shah M; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Ahmed S; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Healey CS; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Gorman M; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Martin L; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Hodgson S; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Fasching PA; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Hein A; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Beckmann MW; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Ekici AB; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Hall P; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Czene K; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Darabi H; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Li J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Dürst M; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Runnebaum I; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Hillemanns P; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Dörk T; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Lambrechts D; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Depreeuw J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Annibali D; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Amant F; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Zhao H; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Goode EL; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Dowdy SC; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Fridley BL; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Winham SJ; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Salvesen HB; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Njølstad TS; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Trovik J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Werner HM; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Tham E; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Liu T; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Mints M; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Bolla MK; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Michailidou K; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Tyrer JP; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Wang Q; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Hopper JL; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Peto J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Swerdlow AJ; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Burwinkel B; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Brenner H; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Meindl A; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Brauch H; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Lindblom A; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Chang-Claude J; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Couch FJ; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Giles GG; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Kristensen VN; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Cox A; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Pharoah PD; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Dunning AM; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Tomlinson I; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Easton DF; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Thompson DJ; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics, Spurdle AB; Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, Queensland 4006, Australia Wellcome Trust Centre for Human Genetics University of Oxford, Oxford OX3 7BN, UK Department of Public Health and Primary Care Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Hunter Medical Research Institute John Hunter Hospital, Newcastle, New South Wales 2305, Australia School of Medicine and Public Health Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, New South Wales 2305, Australia Hunter Area Pathology Service John Hunter Hospital, Newcastle, New South Wales 2305, Australia Centre for Information Based Medicine School of Biomedical Sciences and Pharmacy School of Medicine and Public Health University of Newcastle, Newcastle, New South Wales 2308, Australia Department of Oncology Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK Department of Clinical Genetics St George's, University of London, London SW17 0RE, UK Division of Hematology/Oncology Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA Department of Gynecology and Obstetrics University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91054, Germany Institute of Human Genetics University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, Germany Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm SE-171 77, Sweden Department of Gynaecology Jena University Hospital - Friedrich Schiller University, Jena 07743, Germany Hannover Medical School Clinics of Gynaecology and Obstetrics, Hannover 30625, Germany Gynaecology Research Unit Hannover Medical School, Hannover 30625, Germany Vesalius Research Center Leuven 3000, Belgium Laboratory for Translational Genetics

Publikováno v: Endocrine-related cancer [Endocr Relat Cancer] 2015 Oct; Vol. 22 (5), pp. 851-61.

Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas.

Autor: Njølstad TS; Department of Clinical Science, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway., Engerud H, Werner HM, Salvesen HB, Trovik J

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