Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

Autor: Aline C Planello, Junfeng Ji, Vivek Sharma, Rajat Singhania, Faridah Mbabaali, Fabian Müller, Javier A Alfaro, Christoph Bock, Daniel D De Carvalho, Nizar N Batada

Publikováno v: Cell Regeneration, Vol 3, Iss 1 (2014)

The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem cells (iPSCs) differs from th

Externí odkaz: https://doaj.org/article/ad60bfdc9d964e8fbe4e9b2383862aaa

The impact of the nucleosome code on protein-coding sequence evolution in yeast.

Autor: Tobias Warnecke, Nizar N Batada, Laurence D Hurst

Publikováno v: PLoS Genetics, Vol 4, Iss 11, p e1000250 (2008)

Coding sequence evolution was once thought to be the result of selection on optimal protein function alone. Selection can, however, also act at the RNA level, for example, to facilitate rapid translation or ensure correct splicing. Here, we ask wheth

Externí odkaz: https://doaj.org/article/63d256413cbc407a8b2f4d59f9c53f61

Stratus not altocumulus: a new view of the yeast protein interaction network.

Autor: Nizar N Batada, Teresa Reguly, Ashton Breitkreutz, Lorrie Boucher, Bobby-Joe Breitkreutz, Laurence D Hurst, Mike Tyers

Publikováno v: PLoS Biology, Vol 4, Iss 10, p e317 (2006)

Systems biology approaches can reveal intermediary levels of organization between genotype and phenotype that often underlie biological phenomena such as polygenic effects and protein dispensability. An important conceptualization is the module, whic

Externí odkaz: https://doaj.org/article/ade6852d27b0446a9966f161381f1a17

Spatial regulation and the rate of signal transduction activation.

Autor: Nizar N Batada, Larry A Shepp, David O Siegmund, Michael Levitt

Publikováno v: PLoS Computational Biology, Vol 2, Iss 5, p e44 (2006)

Of the many important signaling events that take place on the surface of a mammalian cell, activation of signal transduction pathways via interactions of cell surface receptors is one of the most important. Evidence suggests that cell surface protein

Externí odkaz: https://doaj.org/article/7e25a361efeb4f9bbfa1b86fbb8aecd5

Systemic Influences of Mammary Cancer on Monocytes in Mice

Autor: Amy Robinson, Matthew Burgess, Sheila Webb, Pieter A. Louwe, Zhengyu Ouyang, Dylan Skola, Claudia Z. Han, Nizar N. Batada, Víctor González-Huici, Luca Cassetta, Chris K. Glass, Stephen J. Jenkins, Jeffery W. Pollard

Publikováno v: Cancers, Vol 14, Iss 833, p 833 (2022)
Cancers; Volume 14; Issue 3; Pages: 833
Robinson, A, Webb, S, Louwe, P, Ouyang, Z, Skola, D, Han, C Z, Batada, N N, Gonzalez-Huici, V, Cassetta, L, Glass, C K, Jenkins, S J & Pollard, J W 2022, ' Systemic influences of mammary cancer on monocytes in mice ', Cancers, vol. 14, no. 3, 833 . https://doi.org/10.3390/cancers14030833

There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here, we show that there is an increase in the number of bone marrow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fda2914e4b74f5992a3b272e07e6535
https://pubmed.ncbi.nlm.nih.gov/35159100