Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Nizar Hami"'
Autor:
Chris Jenske de Witte, Jose Espejo Valle-Inclan, Nizar Hami, Kadi Lõhmussaar, Oded Kopper, Celien Philomena Henrieke Vreuls, Geertruida Nellie Jonges, Paul van Diest, Luan Nguyen, Hans Clevers, Wigard Pieter Kloosterman, Edwin Cuppen, Hugo Johannes Gerhardus Snippert, Ronald Peter Zweemer, Petronella Oda Witteveen, Ellen Stelloo
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107762- (2020)
Summary: There remains an unmet need for preclinical models to enable personalized therapy for ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids (PDOs) to predict clinical drug response and functional consequenc
Externí odkaz:
https://doaj.org/article/710cd95200e946f6b51756da239c114a
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 3. Z-scores of significantly differential expressed genes (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd7a5cdaea3cae2756f7f3ba9a1d2b0
https://doi.org/10.1158/1541-7786.22516890
https://doi.org/10.1158/1541-7786.22516890
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 2. Differential Gene Expression Analysis on BRAF (fusion) gene expressing organoid lines (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83b7cfca6f3763b19eeb21621703961
https://doi.org/10.1158/1541-7786.22516893
https://doi.org/10.1158/1541-7786.22516893
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic gene fusions, with fusion frequencies of 0.2%–3% throughout different cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8629dd530804e56c9fe1b264e5794128
https://doi.org/10.1158/1541-7786.c.6541530
https://doi.org/10.1158/1541-7786.c.6541530
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4aaa5fed854746109257e41a9a600b
https://doi.org/10.1158/1541-7786.22516905
https://doi.org/10.1158/1541-7786.22516905
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 1. KSEA kinase scores and kinase-substrate links identified in phosphoproteomic screen (provided separately due to size)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7756805d064facf4c02a067cf0b356c9
https://doi.org/10.1158/1541-7786.22516896
https://doi.org/10.1158/1541-7786.22516896
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Table 4. List of BRAF (fusion) gene and GFP-specific primers. Primer used for breakpoint PCR, HA-tag spanning PCR and for the gateway cloning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9142eb90faef125f8320a8a0450b28ad
https://doi.org/10.1158/1541-7786.22516887.v1
https://doi.org/10.1158/1541-7786.22516887.v1
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
S1. Impact of BRAF (fusion) gene expression on phosphorylation of AKT. S2. BRAF (fusion) gene mRNA and protein expression levels. S3. Phosphoproteomics screen in HEK293 cells reveals that BRAF fusions and BRAFV600E activate similar signaling pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e23fd78f6548eccc1846c27443f1fd0
https://doi.org/10.1158/1541-7786.22516902.v1
https://doi.org/10.1158/1541-7786.22516902.v1
Autor:
W.P. Kloosterman, Hugo J.G. Snippert, Emile E. Voest, Marco J. Koudijs, Robert M. van Es, Harmjan R. Vos, Ingrid Verlaan-Klink, Nizar Hami, Markus J. van Roosmalen, Jasmin B. Post, Christina Stangl
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18409e24050fe6bfefac3684c42e4504
https://doi.org/10.1158/1541-7786.22516899
https://doi.org/10.1158/1541-7786.22516899
Autor:
Markus J. van Roosmalen, Jasmin B. Post, Wigard P. Kloosterman, Marco J. Koudijs, Emile E. Voest, Hugo J. Snippert, Christina Stangl, Nizar Hami, Harmjan R. Vos, Robert M. van Es, Ingrid Verlaan-Klink
Publikováno v:
Molecular Cancer Research. 18:537-548
Fusion genes can be oncogenic drivers in a variety of cancer types and represent potential targets for targeted therapy. The BRAF gene is frequently involved in oncogenic gene fusions, with fusion frequencies of 0.2%–3% throughout different cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e3ed1819360fabf4c4cff2c1543793
https://doi.org/10.1158/1541-7786.mcr-19-0529
https://doi.org/10.1158/1541-7786.mcr-19-0529