Mitochondrial DNA structure of an isolated Tunisian Berber population and its relationship with Mediterranean populations

Autor: Nizar Ben Halim, Sana Hsouna, Khaled Lasram, Mariem Chargui, Laaroussi Khemira, Rachid Saidane, Sonia Abdelhak, Rym Kefi

Publikováno v: Annals of Human Biology, Vol 45, Iss 1, Pp 86-97 (2018)

Background: Douiret is an isolated Berber population from South-Eastern Tunisia. The strong geographic and cultural isolation characterising this population might have contributed to remarkable endogamy and consanguinity, which were practiced for sev

Externí odkaz: https://doaj.org/article/9f7bc6ec21a344659691ecd2c9cb1ae8

Mitochondrial DNA structure of an isolated Tunisian Berber population and its relationship with Mediterranean populations

Autor: Sana Hsouna, Rachid Saidane, Sonia Abdelhak, Laaroussi Khemira, Khaled Lasram, Nizar Ben Halim, Mariem Chargui, Rym Kefi

Publikováno v: Annals of Human Biology
Annals of Human Biology, Taylor & Francis, 2018, 45 (1), pp.86--97. ⟨10.1080/03014460.2017.1414875⟩

International audience; BACKGROUND Douiret is an isolated Berber population from South-Eastern Tunisia. The strong geographic and cultural isolation characterising this population might have contributed to remarkable endogamy and consanguinity, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cd53bbd9b81647cc98dfaf8f2e67c2
https://doi.org/10.1080/03014460.2017.1414875

Determination of arylsulfatase A pseudodeficiency allele and haplotype frequency in the Tunisian population

Autor: Ahmed Rebai, Sonia Abdelhak, Imen Dorboz, Majdi Nagara, Lilia Romdhane, Najoua Miladi, Najla Kharrat, Odile Boespflug-Tanguy, Nizar Ben Halim, Nissaf Ben Alaya-Bouafif, Eleonore Eymard-Pierre, Rym Kefi

Publikováno v: Neurological Sciences
Neurological Sciences, Springer Verlag, 2016, 37 (3), pp.403-409. ⟨10.1007/s10072-015-2417-5⟩
Neurological Sciences, 2016, 37 (3), pp.403-409. ⟨10.1007/s10072-015-2417-5⟩

International audience; Arylsulfatase A (ASA) is a lysosomal enzyme involved in the catabolism of cerebroside sulfate. ASA deficiency is associated with metachromatic leukodystrophy (MLD). Low ASA activities have also been reported in a more common c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459b1b5a9fea8f079d48155bc2a67dbb
https://doi.org/10.1007/s10072-015-2417-5

Differential impact of consanguineous marriages on autosomal recessive diseases in Tunisia

Autor: Slim Ben Ammar, Neji Tebib, Farah Ouechtati, Khaled Lasram, Marie Françoise Ben Dridi, Faten Talmoudi, Rym Kefi, Houyem Ouragini, Nizar Ben Halim, Insaf Rejeb, Olfa Messaoud, Asma Walha, Yosra Bouyacoub, Sonia Abdelhak, Mourad Mokni, Ahlem Amouri, Habib Messai, Sana Hsouna, Majdi Nagara, Ahlem Sabrine Ben Brick, Wafa Cherif, Leila El Matri, Faten Ben Rhouma, I. Chouchene, Mariem Ben Rekaya

Publikováno v: American Journal of Human Biology. 28:171-180

Objectives Consanguinity is common in Tunisia. However, little information exists on its impact on recessive disorders. In this study, we evaluate the impact of consanguineous marriages on the occurrence of some specific autosomal recessive disorders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4de7f5fa3c497e90f4264cfcb27a3572
https://doi.org/10.1002/ajhb.22764

Specific Aspects of Consanguinity: Some Examples from the Tunisian Population

Autor: Crystel Bonnet, Mariem Ben Rekaya, Nizar Ben Halim, Yosra Bouyacoub, Giovanni Romeo, Insaf Rejeb, Olfa Messaoud, Faten Ben Rhouma, Lilia Romdhane, Christine Petit, Habib Messai, Zied Riahi, Sonia Abdelhak, Rym Kefi, Majdi Nagara, Ken McElreavey

Publikováno v: Human Heredity
Human Heredity, Karger, 2014, 77 (1-4), pp.167-74. ⟨10.1159/000362167⟩
Human Heredity, 2014, 77 (1-4), pp.167-74. ⟨10.1159/000362167⟩

International audience; Located at the cross-road between Europe and Africa, Tunisia is a North African country of 11 million inhabitants. Throughout its history, it has been invaded by different ethnic groups. These historical events, and consanguin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae8973b9d253a7b933a1b5bf48e6ac
https://doi.org/10.1159/000362167