Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Nizar A. Al-Shar'I"'
Publikováno v:
Pharmaceutical Sciences, Vol 30, Iss 4, Pp 456-468 (2024)
Background: T-LAK cell-originated protein kinase (TOPK), a member of the MEK3/6-related mitogen-activated protein kinase kinase (MAPKK) family, is highly overexpressed in various cancers. This overexpression is linked to the mitotic phase of the cell
Externí odkaz:
https://doaj.org/article/12b8d52ebe4e44f3959e7db987a3d19c
Publikováno v:
Journal of Saudi Chemical Society, Vol 26, Iss 3, Pp 101482- (2022)
Background: SMYD3 is a protein lysine methyltransferase that methylates lysine in histone and non-histone proteins resulting in regulation of gene transcription and cell signaling pathways. It has been established that SMYD3 enzyme is upregulated in
Externí odkaz:
https://doaj.org/article/493fbb16e31544918fef24450b461c37
Autor:
Pran Kishore Deb, Nizar A. Al-Shar’i, Katharigatta N. Venugopala, Melendhran Pillay, Pobitra Borah
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 869-884 (2021)
The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics. To this end, a series of 3,5-disub
Externí odkaz:
https://doaj.org/article/b101f5f183424dad8acad9e590c3a69a
Autor:
Katharigatta N. Venugopala, Sandeep Chandrashekharappa, Pran Kishore Deb, Christophe Tratrat, Melendhran Pillay, Deepak Chopra, Nizar A. Al-Shar’i, Wafa Hourani, Lina A. Dahabiyeh, Pobitra Borah, Rahul D. Nagdeve, Susanta K. Nayak, Basavaraj Padmashali, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Michelyne Haroun, Sheena Shashikanth, Viresh Mohanlall, Raghuprasad Mailavaram
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1471-1486 (2021)
A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compound
Externí odkaz:
https://doaj.org/article/317149f295104f1dbe7c0e6553495828
Autor:
Rajashri Bezbaruah, Pobitra Borah, Bibhuti Bhushan Kakoti, Nizar A. Al-Shar’I, Balakumar Chandrasekaran, Da’san M. M. Jaradat, Munir A. Al-Zeer, Saeid Abu-Romman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, arose at the end of 2019 as a zoonotic virus, which is the causative agent of the novel coronavirus outbreak COVID-19. Without any clear indications of abatement, the disease has become a m
Externí odkaz:
https://doaj.org/article/491d5e8fa38f455abf76016493893f58
Autor:
Pobitra Borah, Pran Kishore Deb, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Katharigatta N. Venugopala, Vinayak Singh, Pottathil Shinu, Snawar Hussain, Satyendra Deka, Balakumar Chandrasekaran, Da’san M. M. Jaradat
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
With the current outbreak caused by SARS-CoV-2, vaccination is acclaimed as a public health care priority. Rapid genetic sequencing of SARS-CoV-2 has triggered the scientific community to search for effective vaccines. Collaborative approaches from r
Externí odkaz:
https://doaj.org/article/436c2bebdae14321991a8bd13fee9c3c
Autor:
Pobitra Borah, Pran Kishore Deb, Balakumar Chandrasekaran, Manoj Goyal, Monika Bansal, Snawar Hussain, Pottathil Shinu, Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Satyendra Deka, Vinayak Singh
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the angiotensin-converting enzyme 2 (ACE2) receptor and invade the human cells to cause COVID-19-related pneumonia. Despite an emphasis on respiratory complications, the evidence o
Externí odkaz:
https://doaj.org/article/0953f66fe2674df68eff68817c8341a2
Autor:
Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Wafa Hourani, Pran Kishore Deb, Melendhran Pillay, Bashaer Abu-Irmaileh, Yasser Bustanji, Sandeep Chandrashekharappa, Christophe Tratrat, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Pottathil Shinu, Michelyne Haroun, Mahmoud Kandeel, Abdulmalek Ahmed Balgoname, Rashmi Venugopala, Mohamed A. Morsy
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 831 (2022)
A series of 2,3-dihydroquinazolin-4(1H)-one derivatives (3a–3m) was screened for in vitro whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 3l an
Externí odkaz:
https://doaj.org/article/6cf9acd88ee14653afc00830d58d75af
Autor:
Katharigatta N. Venugopala, Pottathil Shinu, Christophe Tratrat, Pran Kishore Deb, Raquel M. Gleiser, Sandeep Chandrashekharappa, Deepak Chopra, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Fawzi M. Mahomoodally, Michelyne Haroun, Mahmoud Kandeel, Syed Mohammed Basheeruddin Asdaq, Viresh Mohanlall, Nizar A. Al-Shar’i, Mohamed A. Morsy
Publikováno v:
Molecules, Vol 27, Iss 9, p 2676 (2022)
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives agai
Externí odkaz:
https://doaj.org/article/93c72a09147b4eaa9ec3e683e05a5128
Autor:
Suaad A. Audat, Nizar A. Al-Shar’i, Buthina A. Al-Oudat, Amanda Bryant-Friedrich, Mel F. Bedi, Aref L. Zayed, Qosay A. Al-Balas
Publikováno v:
Molecules, Vol 25, Iss 12, p 2871 (2020)
Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H). Compounds capable of limit
Externí odkaz:
https://doaj.org/article/ed23270042104febb9ac5394ef5b2524