One-Step Regioselective Synthesis of N-1-Substituted Dihydrouracils: A Motif of Growing Popularity in the Targeted Protein Degradation Field.

Autor: Nixon IDG; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Bateman JM; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Michaelides IN; Hit Discovery, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Fairley G; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Pemberton MJ; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Braybrooke EL; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom., Sutton K; Medicinal Chemistry, Oncology R&D, AstraZeneca, Charter Way, Macclesfield SK10 2NA, United Kingdom., Lindsay-Scott PJ; Medicinal Chemistry, Oncology R&D, AstraZeneca, The Discovery Centre, 1 Francis Crick Avenue, Cambridge CB2 0AA, United Kingdom.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Dec 20; Vol. 89 (24), pp. 18301-18312. Date of Electronic Publication: 2024 Dec 10.