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Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis .

Autor: Jeffreys LN; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Ardrey A; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Hafiz TA; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Dyer LA; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Warman AJ; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Mosallam N; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Nixon GL; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Fisher NE; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Hong WD; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Leung SC; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Aljayyoussi G; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Bibby J; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Almeida DV; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States., Converse PJ; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States., Fotouhi N; Global Alliance for TB Drug Development, New York, New York10005, United States., Berry NG; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Nuermberger EL; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland21205, United States., Upton AM; Global Alliance for TB Drug Development, New York, New York10005, United States.; Evotec (US) Inc., 303B College Road East, Princeton, New Jersey08540, United States., O'Neill PM; Department of Chemistry, University of Liverpool, LiverpoolL69 7ZD, U.K., Ward SA; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K., Biagini GA; Centre for Drugs and Diagnostics, Department of Tropical Infectious Diseases, Liverpool School of Tropical Medicine, Pembroke Place, LiverpoolL3 5QA, U.K.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2023 Feb 10; Vol. 9 (2), pp. 221-238. Date of Electronic Publication: 2023 Jan 06.

Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.

Autor: Woodley CM; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom., Nixon GL; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom., Basilico N; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy.; Affiliated to Centro Interuniversitario di Ricerche sulla Malaria/Italian Malaria Network (CIRM-IMN), Università degli Studi di Milano, 20133 Milano, Italy., Parapini S; Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy.; Affiliated to Centro Interuniversitario di Ricerche sulla Malaria/Italian Malaria Network (CIRM-IMN), Università degli Studi di Milano, 20133 Milano, Italy., Hong WD; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom., Ward SA; Centre for Drugs and Diagnostics. Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom., Biagini GA; Centre for Drugs and Diagnostics. Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom., Leung SC; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom., Taramelli D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy.; Affiliated to Centro Interuniversitario di Ricerche sulla Malaria/Italian Malaria Network (CIRM-IMN), Università degli Studi di Milano, 20133 Milano, Italy., Onuma K; Eisai Co.,Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai, Tsukubashi, Ibaraki 300-2635, Japan., Hasebe T; Eisai Co.,Ltd. Tsukuba Research Laboratories, 5-1-3 Tokodai, Tsukubashi, Ibaraki 300-2635, Japan., O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jun 24; Vol. 12 (7), pp. 1077-1085. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).

AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis.

Autor: Hong WD; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom.; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Benayoud F; Eisai AiM Institute, Eisai, Inc., Andover, MA 01810., Nixon GL; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom., Ford L; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Johnston KL; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Clare RH; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Cassidy A; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Cook DAN; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Siu A; Eisai AiM Institute, Eisai, Inc., Andover, MA 01810., Shiotani M; Drug Safety, Eisai Co., Ltd., 300-2635 Tsukuba, Japan., Webborn PJH; Drug Safety & Metabolism, IMED Biotech Unit, AstraZeneca UK, CB2 0AA Cambridge, United Kingdom., Kavanagh S; Drug Safety & Metabolism, IMED Biotech Unit, AstraZeneca UK, CB2 0AA Cambridge, United Kingdom., Aljayyoussi G; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Murphy E; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Steven A; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Archer J; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Struever D; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany., Frohberger SJ; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany., Ehrens A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany., Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany., Hoerauf A; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53127 Bonn, Germany., Roberts AP; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Hubbard ATM; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Tate EW; Department of Chemistry, Imperial College London, SW7 2AZ London, United Kingdom., Serwa RA; Department of Chemistry, Imperial College London, SW7 2AZ London, United Kingdom., Leung SC; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom.; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Qie L; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom., Berry NG; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom., Gusovsky F; Eisai AiM Institute, Eisai, Inc., Andover, MA 01810., Hemingway J; Department of International Health, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom janet.hemingway@lstmed.ac.uk steve.ward@lstmed.ac.uk pmoneill@liverpool.ac.uk., Turner JD; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Taylor MJ; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom., Ward SA; Research Centre for Drugs and Diagnostics, Department of Parasitology, Liverpool School of Tropical Medicine, L3 5QA Liverpool, United Kingdom; janet.hemingway@lstmed.ac.uk steve.ward@lstmed.ac.uk pmoneill@liverpool.ac.uk., O'Neill PM; Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom; janet.hemingway@lstmed.ac.uk steve.ward@lstmed.ac.uk pmoneill@liverpool.ac.uk.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jan 22; Vol. 116 (4), pp. 1414-1419. Date of Electronic Publication: 2019 Jan 07.

Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Q i ) Inhibitors with Improved Drug-like Properties.

Autor: David Hong W; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K., Leung SC; Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K., Amporndanai K; Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, U.K., Davies J; Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K., Priestley RS; Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K., Nixon GL; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K., Berry NG; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K., Samar Hasnain S; Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, U.K., Antonyuk S; Molecular Biophysics Group, Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, U.K., Ward SA; Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K., Biagini GA; Research Centre for Drugs & Diagnostics, Parasitology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, U.K., O'Neill PM; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, U.K.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Oct 19; Vol. 9 (12), pp. 1205-1210. Date of Electronic Publication: 2018 Oct 19 (Print Publication: 2018).