The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial.

Autor: Singh RD; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands., van Dijck JTJM; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands., van Essen TA; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands.; Department of Surgery, Division of Neurosurgery, QEll Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada., Nix HP; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Vreeburg RJG; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands., den Boogert HF; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands., de Ruiter GCW; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands., Depreitere B; University Hospital Leuven (UZ Leuven), Department of Neurosurgery, Leuven, Belgium., Peul WC; University Neurosurgical Center Holland (UNCH), Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC) and Haga Teaching Hospital, Department of Neurosurgery, Leiden and The Hague, the Netherlands.

Publikováno v: Brain & spine [Brain Spine] 2024 Jul 18; Vol. 4, pp. 102903. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).

Preventing Respiratory Viral Illness Invisibly (PRiVII): protocol for a pragmatic cluster randomized trial evaluating far-UVC light devices in long-term care facilities to reduce infections.

Autor: Nix HP; Geriatric Medicine Research, Halifax, NS, Canada. hnix@dal.ca.; Department of Medicine, Dalhousie University, Halifax, NS, Canada. hnix@dal.ca., Meeker S; Geriatric Medicine Research, Halifax, NS, Canada., King CE; Research, Innovation and Discovery, Nova Scotia Health, Halifax, NS, Canada., Andrew M; Department of Medicine, Dalhousie University, Halifax, NS, Canada.; Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada., Davis IRC; Division of Infectious Diseases, Department of Medicine, Nova Scotia Health, Halifax, NS, Canada.; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada., Koto PS; Research Methods Unit, Nova Scotia Health, Halifax, NS, Canada., Sim M; Research, Innovation and Discovery, Nova Scotia Health, Halifax, NS, Canada., Murdoch J; Research, Innovation and Discovery, Nova Scotia Health, Halifax, NS, Canada., Patriquin G; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Nova Scotia Health, Halifax, NS, Canada., Theriault C; Research Methods Unit, Nova Scotia Health, Halifax, NS, Canada., Reidy S; Geriatric Medicine Research, Halifax, NS, Canada.; Division of Rheumatology, Nova Scotia Health, Halifax, NS, Canada., Rockwood M; Geriatric Medicine Research, Halifax, NS, Canada., Sampalli T; Research, Innovation and Discovery, Nova Scotia Health, Halifax, NS, Canada., Searle SD; Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.; Medical Research Council Unit for Lifelong Health and Ageing at University College London, University College London, London, UK., Rockwood K; Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada.; Frailty & Elder Care Network, Nova Scotia Health, Halifax, NS, Canada.

Publikováno v: Trials [Trials] 2024 Jan 26; Vol. 25 (1), pp. 88. Date of Electronic Publication: 2024 Jan 26.

An analysis of published trials found that current use of pragmatic trial labels is uninformative.

Autor: Taljaard M; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Centre for Practice-Changing Research, The Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: mtaljaard@ohri.ca., Nicholls SG; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Centre for Practice-Changing Research, The Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada., Howie AH; Western Centre for Public Health and Family Medicine, 1465 Richmond St., London, Ontario N6G 2M1, Canada., Nix HP; Schulich School of Medicine & Dentistry, Western University, London, Ontario N6G 2M1, Canada., Carroll K; Ottawa Hospital Research Institute, Clinical Epidemiology Program, Centre for Practice-Changing Research, The Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada., Moon PM; Department of Family Medicine, Western Centre for Public Health and Family Medicine, 1465 Richmond St., London, Ontario N6G 2M1, Canada., Nightingale NM; Western Centre for Public Health and Family Medicine, 1465 Richmond St., London, Ontario N6G 2M1, Canada., Giraudeau B; Université de Tours, Université de Nantes, INSERM, SPHERE U1246, Tours, France; INSERM CIC1415, CHRU de Tours, Tours, France., Hey SP; Center for Bioethics, Harvard Medical School, Boston, MA, USA., Eldridge SM; Wolfson Institute of Population Health, Queen Mary University of London, 58 Turner Street, London, E1 2AB, UK., Weijer C; Departments of Medicine, Epidemiology & Biostatistics, and Philosophy, Western University, London, Ontario N6A 5W9, Canada., Zwarenstein M; Department of Family Medicine, Western Centre for Public Health and Family Medicine, 1465 Richmond St., London, Ontario N6G 2M1, Canada.

Publikováno v: Journal of clinical epidemiology [J Clin Epidemiol] 2022 Nov; Vol. 151, pp. 113-121. Date of Electronic Publication: 2022 Aug 18.

Canadian perspective on ageism and selective lockdown: a response to Savulescu and Cameron.

Autor: Nix HP; Uehiro Centre for Practical Ethics, Oxford University, Oxford, Oxfordshire, UK hnix@uwo.ca.; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.

Publikováno v: Journal of medical ethics [J Med Ethics] 2022 Apr; Vol. 48 (4), pp. 268-269. Date of Electronic Publication: 2021 Mar 11.

Informed consent in pragmatic trials: results from a survey of trials published 2014-2019.

Autor: Zhang JZ; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Nicholls SG; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Carroll K; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Nix HP; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Goldstein CE; Philosophy, Rotman Institute of Philosophy, London, Ontario, Canada., Hey SP; Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA., Brehaut JC; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., McLean PC; Boston, Massachusetts, USA., Weijer C; Medicine, Epidemiology and Biostatistics, and Philosophy, Western University, London, Ontario, Canada., Fergusson DA; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Medicine, University of Ottawa, Ottawa, Ontario, Canada., Taljaard M; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada mtaljaard@ohri.ca.; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Publikováno v: Journal of medical ethics [J Med Ethics] 2021 Nov 15. Date of Electronic Publication: 2021 Nov 15.