B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma

Autor: Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N. Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J. Harris, Silvia Mele, Giulia Pellizzari, Anna B. M. Black, Heather J. Bax, Anthony Cheung, Mano Nakamura, Ricarda M. Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K. Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K. Dunn-Walters, Eleftherios P. Diamandis, Sophia Tsoka, James Spicer, Katie E. Lacy, Franca Fraternali, Sophia N. Karagiannis

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in sampl

Externí odkaz: https://doaj.org/article/ec79417fc51f4749a49432bb35eb4eff

Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4

Autor: Jitesh Chauhan, Melanie Grandits, Lais C. G. F. Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M. Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E. Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M. Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A. Lionarons, Hannah J. Gould, Andrew J. Beavil, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O. Nestle, Sophia Tsoka, Debra H. Josephs, Philip J. Blower, Panagiotis Karagiannis, Katie E. Lacy, James Spicer, Sophia N. Karagiannis, Heather J. Bax

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated antigen chondroitin sulfate proteoglycan 4 (CSPG4) expression is ~70%, therefore effec

Externí odkaz: https://doaj.org/article/eeac938a111045e186e031edbfe48da6

Effects of Exercise-Induced Hypoalgesia at Different Aerobic Exercise Intensities in Healthy Young Adults

Autor: Niwa Y, Shimo K, Ohga S, Tokiwa Y, Hattori T, Matsubara T

Publikováno v: Journal of Pain Research, Vol Volume 15, Pp 3615-3624 (2022)

Yuto Niwa,1 Kazuhiro Shimo,2 Satoshi Ohga,2 Yuji Tokiwa,1 Takafumi Hattori,1 Takako Matsubara1,2 1Faculty of Rehabilitation, Kobe Gakuin University Graduate School, Kobe, Japan; 2Department of Physical Therapy, Faculty of Rehabilitation, Kobe Gakuin

Externí odkaz: https://doaj.org/article/b1bfb707276b41808c0d975a33b63fa7

La Clientela de la prostitución en el estado español

Autor: Niwa Escalona

Publikováno v: Revista del laboratorio iberoamericano para el estudio sociohistórico de las sexualidades, Iss 9 (2023)

Este trabajo se centra en la figura del cliente y lo que su existencia supone para la trabajadora sexual. Indagamos en los supuestos motivos que conducen al consumo de sexo de pago y cuestionamos la existencia de los distintos perfiles que lo conform

Externí odkaz: https://doaj.org/article/329bbe96030f4bc1bc290d4e9768e6a6

GRB 221009A: the B.O.A.T Burst that Shines in Gamma Rays

Autor: Axelsson, M., Ajello, M., Arimoto, M., Baldini, L., Ballet, J., Baring, M. G., Bartolini, C., Bastieri, D., Gonzalez, J. Becerra, Bellazzini, R., Berenji, B., Bissaldi, E., Blandford, R. D., Bonino, R., Bruel, P., Buson, S., Cameron, R. A., Caputo, R., Caraveo, P. A., Cavazzuti, E., Cheung, C. C., Chiaro, G., Cibrario, N., Ciprini, S., Cozzolongo, G., Orestano, P. Cristarella, Crnogorcevic, M., Cuoco, A., Cutini, S., D'Ammando, F., De Gaetano, S., Di Lalla, N., Dinesh, A., Di Tria, R., Di Venere, L., Domínguez, A., Fegan, S. J., Ferrara, E. C., Fiori, A., Franckowiak, A., Fukazawa, Y., Funk, S., Fusco, P., Galanti, G., Gargano, F., Gasbarra, C., Germani, S., Giacchino, F., Giglietto, N., Giliberti, M., Gill, R., Giordano, F., Giroletti, M., Granot, J., Green, D., Grenier, I. A., Guiriec, S., Gustafsson, M., Hashizume, M., Hays, E., Hewitt, J. W., Horan, D., Kayanoki, T., Kuss, M., Laviron, A., Li, J., Liodakis, I., Longo, F., Loparco, F., Lorusso, L., Lott, B., Lovellette, M. N., Lubrano, P., Maldera, S., Malyshev, D., Manfreda, A., Martí-Devesa, G., Martinelli, R., Castellanos, I. Martinez, Mazziotta, M. N., McEnery, J. E., Mereu, I., Meyer, M., Michelson, P. F., Mirabal, N., Mitthumsiri, W., Mizuno, T., Monti-Guarnieri, P., Monzani, M. E., Morishita, T., Morselli, A., Moskalenko, I. V., Negro, M., Niwa, R., Omodei, N., Orienti, M., Orlando, E., Paneque, D., Panzarini, G., Persic, M., Pesce-Rollins, M., Petrosian, V., Pillera, R., Piron, F., Porter, T. A., Principe, G., Racusin, J. L., Rainò, S., Rando, R., Rani, B., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Ryde, F., Sánchez-Conde, M., Parkinson, P. M. Saz, Serini, D., Sgrò, C., Sharma, V., Siskind, E. J., Spandre, G., Spinelli, P., Suson, D. J., Tajima, H., Tak, D., Thayer, J. B., Torres, D. F., Valverde, J., Zaharijas, G., Lesage, S., Briggs, M. S., Burns, E., Bala, S., Bhat, P. N., Cleveland, W. H., Dalessi, S., de Barra, C., Gibby, M., Giles, M. M., Hamburg, R., Hristov, B. A., Hui, C. M., Kocevski, D., Mailyan, B., Malacaria, C., McBreen, S., Poolakkil, S., Roberts, O. J., Scotton, L., Veres, P., von Kienlin, A., Wilson-Hodge, C. A., Wood, J.

We present a complete analysis of Fermi Large Area Telescope (LAT) data of GRB 221009A, the brightest Gamma-Ray Burst (GRB) ever detected. The burst emission above 30 MeV detected by the LAT preceded by 1 s the low-energy (< 10 MeV) pulse that trigge

Externí odkaz: http://arxiv.org/abs/2409.04580