Eukaryotic transcription factors can track and control their target genes using DNA antennas

Autor: Victor Muñoz, Nivin Mothi, Milagros Castellanos

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC

Eukaryotic transcription factors (TF) function by binding to short 6-10 bp DNA recognition sites located near their target genes, which are scattered through vast genomes. Such process surmounts enormous specificity, efficiency and celerity challenge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9e583e9dd408c35e0f5fcea6d7557a
https://doaj.org/article/38700698f55c42fb823accdade214c7c

Single-Molecule Fluorescence Spectroscopy Approaches for Probing Fast Biomolecular Dynamics and Interactions

Autor: Zifan Wang, Victor Muñoz, Nivin Mothi

Publikováno v: Protein Folding ISBN: 9781071617151

Single-molecule fluorescence spectroscopy, and particularly its Forster resonance energy transfer implementation (SM-FRET), provides the opportunity to resolve the stochastic conformational fluctuations undergone by individual protein molecules while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93a6cfb05010bacb2aa83909b6515249
https://doi.org/10.1007/978-1-0716-1716-8_13

Physical basis for the ofloxacin-induced acceleration of lysozyme aggregation and polymorphism in amyloid fibrils

Autor: Shivani A. Muthu, Sonali M. Shiriskar, Nivin Mothi, Basir Ahmad, Raghuvir R. S. Pissurlenkar, Anil Kumar

Publikováno v: Archives of Biochemistry and Biophysics. 592:10-19

Aggregation of globular proteins is an intractable problem which generally originates from partially folded structures. The partially folded structures first collapse non-specifically and then reorganize into amyloid-like fibrils via one or more olig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5252ec2dac7d20e81cb6eb0091fa275
https://doi.org/10.1016/j.abb.2016.01.005

Shining light on clay–chromophore hybrids: layered templates for accelerated ring closure photo-oxidation

Autor: Ankit Jain, Nivin Mothi, Subi J. George, Muthuswamy Eswaramoorthy, Amritroop Achari

Publikováno v: Chemical Science. 6:6334-6340

Templates with specific microenvironments have been long employed to facilitate specialized reactions. From enzymes to metal organic frameworks (MOFs), various systems have exerted their prowess to affect specific chemical reactions. Here we report,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0869e9f223ad1ab627d4508809fe5053
https://doi.org/10.1039/c5sc02215k

Curcumin promotes fibril formation in F isomer of human serum albumin via amorphous aggregation

Autor: Nivin Mothi, Avinash Kale, Basir Ahmad, Shivani A. Muthu

Publikováno v: Biophysical chemistry. 207

We here describe the amyloid fibrils promoting behavior of curcumin, which ability to inhibit amyloid fibrillization of several globular proteins is well documented. Transmission electron microscopy (TEM), 90° light scattering (RLS), thioflavine T (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6daa9097ea04a2d6dfb65fb1bb4af2b
https://pubmed.ncbi.nlm.nih.gov/26298484