Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nivetha Murugesan"'
Autor:
Edward P. Feener, Rebecca L. Davie, Nivetha Murugesan, Stephen J. Pethen, Sally L. Hampton, Michael D. Smith, Paul K. Audhya, Chris M. Yea
Publikováno v:
Drugs and Drug Candidates, Vol 3, Iss 2, Pp 328-341 (2024)
Sebetralstat is a novel, potent, and selective oral plasma kallikrein inhibitor drug candidate in clinical development for the on-demand treatment of hereditary angioedema (HAE). Upon binding, sebetralstat induces a conformational change in the activ
Externí odkaz:
https://doaj.org/article/c898ea85087542009c61e6fcd2741b8b
Publikováno v:
Sustainable Chemistry for the Environment, Vol 6, Iss , Pp 100088- (2024)
Predictions indicate a concerning surge in plastic waste, expected to reach 380 million tonnes by 2040 from 188 million tonnes in 2016. Strategies to combat this could reduce yearly waste to 140 million tonnes, but this may not fully address existing
Externí odkaz:
https://doaj.org/article/9ee6ec04db4b4ca980d7f5921c53e547
Autor:
Allen C. Clermont, Nivetha Murugesan, Hannah J. Edwards, Daniel K. Lee, Natasha P. Bayliss, Edward J. Duckworth, Stephen J. Pethen, Sally L. Hampton, David Gailani, Edward P. Feener
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: The kallikrein kinin system (KKS) is an established pharmacological target for the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic activities of FXIIa and single-chain Factor XII (FXII) zymogen contribute t
Externí odkaz:
https://doaj.org/article/6ba5b7f80e6f4336a608e1a81978ce2e
Autor:
Andreas Maetzel, Michael D. Smith, Edward J. Duckworth, Sally L. Hampton, Gian Marco De Donatis, Nivetha Murugesan, Louise J. Rushbrooke, Lily Li, Danielle Francombe, Edward P. Feener, Christopher M. Yea
Publikováno v:
Journal of Allergy and Clinical Immunology. 149:2034-2042
Attacks of hereditary angioedema are attributed to excessive plasma kallikrein (PKa) activity, which cleaves high-molecular-weight kininogen to generate the proinflammatory hormone bradykinin.We evaluated the safety, tolerability, pharmacokinetics (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d8250a19c23c9a10512bab9913d2f
https://doi.org/10.1016/j.jaci.2021.10.038
https://doi.org/10.1016/j.jaci.2021.10.038
Autor:
Edward J. Duckworth, Nivetha Murugesan, Lily Li, Louise J. Rushbrooke, Daniel K. Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher M. Yea, Sally L. Hampton, Edward P. Feener
Publikováno v:
Clinical & Experimental Allergy. 52:1059-1070
Hereditary angioedema (HAE) is a rare genetic disease that leads to recurrent episodes of swelling and pain caused by uncontrolled plasma kallikrein (PKa) activity. Current guidelines recommend ready availability of on-demand HAE treatments that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fffe1d47acef7a53a0c4c6b2ef74f0
https://doi.org/10.1111/cea.14122
https://doi.org/10.1111/cea.14122
Species often evolve complex signalling mechanisms to communicate within and across species. These traits could have separate evolutionary histories, and understanding the adaptive roles of separate traits can be challenging. We examine the role of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3842007c15c43b77cd6d63d5051deec3
Publikováno v:
Experimental eye research. 186
The plasma kallikrein-stimulated generation of bradykinin (BK) has been implicated in diabetic macular edema (DME). This study characterizes the effects of BK on the ultrastructure and proteome of the rat retina. The effects of intravitreal injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54af7257fad52076462c45d332f036e
https://pubmed.ncbi.nlm.nih.gov/31351056
https://pubmed.ncbi.nlm.nih.gov/31351056
Autor:
Nivetha Murugesan, Rajamani, Nandini
Sexual size dimorphism is common across many species. Males being larger than females is the commonly observed pattern among mammals, and is explained as sexual selection favouring larger males. Some gliding mammals are known to exhibit the opposite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fccfe23381c7b52672005e4c1064b7
Autor:
Edward P. Feener, Lloyd Paul Aiello, Takeshi Kita, Qunfang Zhou, Allen C. Clermont, Nivetha Murugesan, Kimihiko Fujisawa, Tatsuro Ishibashi
Publikováno v:
Diabetes. 64:3588-3599
This study characterizes the kallikrein-kinin system in vitreous from individuals with diabetic macular edema (DME) and examines mechanisms contributing to retinal thickening and retinal vascular permeability (RVP). Plasma prekallikrein (PPK) and pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945ed193d5fbf7a301c20b98c85229ee
https://doi.org/10.2337/db15-0317
https://doi.org/10.2337/db15-0317
Publikováno v:
2017 International Conference on Intelligent Computing, Instrumentation and Control Technologies (ICICICT).
The role of mirna in cancer has been an important development in tumour studies since its discovery in 2002. Recent studies, focuses much on small non-coding RNAs particularly miRNAs as biomarker for cancer detection and diagnosis; however the proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::631622a5a9476c135628d75d798a3d5c
https://doi.org/10.1109/icicict1.2017.8342561
https://doi.org/10.1109/icicict1.2017.8342561