Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Niven R Narain"'
Autor:
Heather E Arsenault, Julie M Ghizzoni, Cassandra M Leech, Anne R Diers, Stephane Gesta, Vivek K Vishnudas, Niven R Narain, Rangaprasad Sarangarajan, Jennifer A Benanti
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractThe spindle assembly checkpoint protects the integrity of the genome by ensuring that chromosomes are properly attached to the mitotic spindle before they are segregated during anaphase. Activation of the spindle checkpoint results in inhibit
Externí odkaz:
https://doaj.org/article/925891e8da284d118b898b3fe1cf5c4a
Autor:
Jonathan M. Dreyfuss, Vera Djordjilović, Hui Pan, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Matthias Blüher, Yu-Hua Tseng, Matthew D. Lynes
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Activating brown adipose tissue (BAT) improves systemic metabolism, making it a promising target for metabolic syndrome. BAT is activated by 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), which we previously identified to be inversely
Externí odkaz:
https://doaj.org/article/afea66cd67a749dc88a7aa390e8ba4af
Autor:
Tadataka Tsuji, Vladimir Tolstikov, Yang Zhang, Tian Lian Huang, Henrique Camara, Meghan Halpin, Niven R. Narain, King-Wai Yau, Matthew D. Lynes, Michael A. Kiebish, Yu-Hua Tseng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the br
Externí odkaz:
https://doaj.org/article/8ecefb11a3cf44199f3ecdef2e29d833
Autor:
Kuan-Wei Peng, Allison Klotz, Arcan Guven, Unnati Kapadnis, Shobha Ravipaty, Vladimir Tolstikov, Vijetha Vemulapalli, Leonardo O. Rodrigues, Hongyan Li, Mark D. Kellogg, Farah Kausar, Linda Rees, Rangaprasad Sarangarajan, Birgitt Schüle, William Langston, Paula Narain, Niven R. Narain, Michael A. Kiebish
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Parkinson’s disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor symptoms with a degree of misdiagno
Externí odkaz:
https://doaj.org/article/7ef1ad93078f4891b7305fd1f6d91e67
Autor:
Dora Ravasz, David Bui, Sara Nazarian, Gergely Pallag, Noemi Karnok, Jennie Roberts, Bryan P. Marzullo, Daniel A. Tennant, Bennett Greenwood, Alex Kitayev, Collin Hill, Timea Komlódi, Carolina Doerrier, Kristyna Cunatova, Erika Fernandez-Vizarra, Erich Gnaiger, Michael A. Kiebish, Alexandra Raska, Krasimir Kolev, Bence Czumbel, Niven R. Narain, Thomas N. Seyfried, Christos Chinopoulos
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)
Abstract Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced compounds in the mitochondrial matrix which impedes dehydrogenases. By simultaneously measuring oxygen concentration, NADH autofluorescence, mitochondrial mem
Externí odkaz:
https://doaj.org/article/453486a76e924fb8b9b5af5d51ebc216
Autor:
Diego Hernández-Saavedra, J. Matthew Hinkley, Lisa A. Baer, Kelsey M. Pinckard, Pablo Vidal, Shinsuke Nirengi, Andrea M. Brennan, Emily Y. Chen, Niven R. Narain, Valerie Bussberg, Vladimir V. Tolstikov, Michael A. Kiebish, Christina Markunas, Olga Ilkayeva, Bret H. Goodpaster, Christopher B. Newgard, Laurie J. Goodyear, Paul M. Coen, Kristin I. Stanford
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109083- (2024)
Summary: Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (AC) (C12-C16) are lower in act
Externí odkaz:
https://doaj.org/article/1fa864323c024e6ea418512ba98137e4
Autor:
Nischal Mahaveer Chand, Poornima K. Tekumalla, Matt T. Rosenberg, Albert Dobi, Amina Ali, Gregory M. Miller, Juan J. Aristizabal-Henao, Elder Granger, Stephen J. Freedland, Mark D. Kellogg, Shiv Srivastava, David G. McLeod, Niven R. Narain, Michael A. Kiebish
Publikováno v:
Cancers, Vol 16, Iss 4, p 712 (2024)
Prostate cancer represents a significant health risk to aging men, in which diagnostic challenges to the identification of aggressive cancers remain unmet. Prostate cancer screening is driven by the prostate-specific antigen (PSA); however, in men wi
Externí odkaz:
https://doaj.org/article/56e0d2224a37444f8776295d07e24c09
Autor:
Jen‐Tsan Chi, Pao‐Hwa Lin, Vladimir Tolstikov, Taofik Oyekunle, Emily Y. Chen, Valerie Bussberg, Bennett Greenwood, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish, Stephen J. Freedland
Publikováno v:
Cancer Medicine, Vol 9, Iss 11, Pp 3691-3702 (2020)
Abstract Androgen deprivation therapy (ADT) is the main treatment strategy for men with metastatic prostate cancer (PC). However, ADT is associated with various metabolic disturbances, including impaired glucose tolerance, insulin resistance and weig
Externí odkaz:
https://doaj.org/article/1b2427342e9445bc90af0db986faebe1
Autor:
Reka Agnes Haraszti, Rachael Miller, Michelle L. Dubuke, Hannah E. Rockwell, Andrew H. Coles, Ellen Sapp, Marie-Cecile Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John Leszyk, Julia F. Alterman, Bruno M.D.C. Godinho, Matthew R. Hassler, Justice McDaniel, Niven R. Narain, Rachel Wollacott, Yang Wang, Scott A. Shaffer, Michael A. Kiebish, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Publikováno v:
iScience, Vol 16, Iss , Pp 230-241 (2019)
Summary: Exosomes can serve as delivery vehicles for advanced therapeutics. The components necessary and sufficient to support exosomal delivery have not been established. Here we connect biochemical composition and activity of exosomes to optimize e
Externí odkaz:
https://doaj.org/article/21894a18485a4c49a1a72ee7b538a0ae
Autor:
Tadataka Tsuji, Valerie Bussberg, Allison M. MacDonald, Niven R. Narain, Michael A. Kiebish, Yu-Hua Tseng
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5321 (2022)
A balanced omega (ω)-6/ω-3 polyunsaturated fatty acids (PUFAs) ratio has been linked to metabolic health and the prevention of chronic diseases. Brown adipose tissue (BAT) specializes in energy expenditure and secretes signaling molecules that regu
Externí odkaz:
https://doaj.org/article/8c9884e566164ac698330f3957181410