Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Nivedhitha Velayutham"'
Autor:
Nivedhitha Velayutham, Jessica C. Garbern, Hannah L. T. Elwell, Zhu Zhuo, Laura Rüland, Farid Elcure Alvarez, Sara Frontini, Yago Rodriguez Carreras, Marie Eichholtz, Elisabeth Ricci‐Blair, Jeanna Y. Shaw, Aldric H. Bouffard, Morgan Sokol, Estela Mancheño Juncosa, Seth Rhoades, Daphne van den Berg, Alexander Kreymerman, Junya Aoyama, Jens Höfflin, Herb Ryan, Shannan Ho Sui, Richard T. Lee
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hiPSC‐C
Externí odkaz:
https://doaj.org/article/0f6ccd0ad57e4a3b9de0de5968e8b89e
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 4, p 93 (2022)
Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal labo
Externí odkaz:
https://doaj.org/article/84253e0f1b1c44959f94c2f923674acb
Publikováno v:
Circulation Research. 129
Background: Adult mammalian cardiomyocytes (CM) are predominantly post-mitotic and cannot proliferatively repair the heart following myocardial infarction (MI). Overexpression of the transcription factor Tbx20 in adult mouse CMs promotes proliferativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6718b9f853c0080ba263e41790bfdb5
https://doi.org/10.1161/res.129.suppl_1.p448
https://doi.org/10.1161/res.129.suppl_1.p448
Autor:
Christina M. Alfieri, Emma J Agnew, Sithara Raju Ponny, Farhan Zafar, Kyle W. Riggs, Katherine E. Yutzey, Nivedhitha Velayutham, Richard Baker
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ec53fa6149e7f52b0925e8d2e75cba
https://doi.org/10.1096/fasebj.2021.35.s1.03211
https://doi.org/10.1096/fasebj.2021.35.s1.03211
Autor:
Farhan Zafar, Emma J Agnew, Christina M. Alfieri, Kyle W. Riggs, Nivedhitha Velayutham, Katherine E. Yutzey, Sithara Raju Ponny, Richard S Baker
Publikováno v:
Circulation. 142
Background: Rodent cardiomyocytes (CM) undergo mitotic arrest and decline of mononucleated-diploid population post-birth, which are implicated in neonatal loss of heart regenerative potential. However, the dynamics of postnatal CM maturation are larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01153abe24d55f66738137d9a9ac3fcb
https://doi.org/10.1161/circ.142.suppl_3.13391
https://doi.org/10.1161/circ.142.suppl_3.13391
Autor:
Emma J Agnew, Kyle W. Riggs, Sithara Raju Ponny, Katherine E. Yutzey, Christina M. Alfieri, R. Scott Baker, Farhan Zafar, Nivedhitha Velayutham
Publikováno v:
J Mol Cell Cardiol
AimsCardiomyocyte (CM) cell cycle arrest, decline of mononucleated-diploid CMs, sarcomeric maturation, and extracellular matrix remodeling are implicated in loss of cardiac regenerative potential in mice after birth. Recent studies show a 3-day neona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecf4e2e92f39a00087c18f0c3d64899
https://doi.org/10.1101/773101
https://doi.org/10.1101/773101
Autor:
Tarek Alsaied, Farhan Zafar, R. Scott Baker, Kyle W. Riggs, Sithara Raju Ponny, Katherine E. Yutzey, Victoria Moore, Emma J Agnew, Gabriela Matos Ortiz, Nivedhitha Velayutham, Aaron M. Gibson, Christina M. Alfieri
Studies in mice show a brief neonatal period of cardiac regeneration with minimal scar formation. Less is known about reparative mechanisms in large mammals. A transient cardiac injury approach (ischemia/reperfusion, IR) was used in weaned postnatal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c36330df10b86932b9c3e3426ee6c2d
https://doi.org/10.1101/773218
https://doi.org/10.1101/773218
Autor:
Emma J Agnew, Nivedhitha Velayutham, Victoria Moore, Richard S Baker, Tarek Alsaied, Farhan Zafar, Kyle W. Riggs, Katherine E. Yutzey
Publikováno v:
Circulation Research. 125
Objective: Infants with severe congenital heart defects (CHD) typically require lifesaving cardiac surgery. Performing this surgery during a time when the myocardium can proliferate and repair could improve successful outcomes. The mouse heart can re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d9c820e529958c8e501f3753cbec984
https://doi.org/10.1161/res.125.suppl_1.131
https://doi.org/10.1161/res.125.suppl_1.131
Autor:
Christina M. Alfieri, Kyle W. Riggs, Katherine E. Yutzey, Emma J Agnew, Farhan Zafar, Nivedhitha Velayutham, Richard S Baker
Publikováno v:
Circulation Research. 125
Objectives: Cardiomyocyte (CM) cell cycle arrest and decline of mononucleated diploid CMs have been implicated in loss of regenerative potential in postnatal mouse hearts. Sarcomeric and extracellular matrix (ECM) maturation also occur concurrently i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68abc842da4788e74746d0774efb6c74
https://doi.org/10.1161/res.125.suppl_1.423
https://doi.org/10.1161/res.125.suppl_1.423
Publikováno v:
Circulation Research. 125
Objectives: During the postnatal period, P0 to P30 in the mouse, the myocardial extracellular matrix (ECM) transitions to a mature profile necessary for increased cardiac output. We hypothesize that, during the postnatal period, cardiac fibroblasts (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddfa8eec0d458f01186eb15aaa0f6fa7
https://doi.org/10.1161/res.125.suppl_1.521
https://doi.org/10.1161/res.125.suppl_1.521