Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nivanthika K Wimalasena"'
Autor:
James P Bohnslav, Nivanthika K Wimalasena, Kelsey J Clausing, Yu Y Dai, David A Yarmolinsky, Tomás Cruz, Adam D Kashlan, M Eugenia Chiappe, Lauren L Orefice, Clifford J Woolf, Christopher D Harvey
Publikováno v:
eLife, Vol 10 (2021)
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://doaj.org/article/0490bc2a85ba4831a27480dbae549b72
Autor:
Zihe Zhang, David P. Roberson, Masakazu Kotoda, Bruno Boivin, James P. Bohnslav, Rafael González-Cano, David A. Yarmolinsky, Bruna Lenfers Turnes, Nivanthika K. Wimalasena, Shay Q. Neufeld, Lee B. Barrett, Nara L. M. Quintão, Victor Fattori, Daniel G. Taub, Alexander B. Wiltschko, Nick A. Andrews, Christopher D. Harvey, Sandeep Robert Datta, Clifford J. Woolf
The lack of sensitive and robust behavioral assessments of pain in preclinical models has been a major limitation for both pain research and the development of novel analgesics. Here, we demonstrate a novel data acquisition and analysis platform that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588f871a1fe1763ad305dec0c5e18f1d
https://hdl.handle.net/10481/78398
https://hdl.handle.net/10481/78398
Autor:
Kelsey J Clausing, Nivanthika K Wimalasena, Lauren L. Orefice, Yu Y Dai, Adam D Kashlan, Christopher D. Harvey, Clifford J. Woolf, M. Eugenia Chiappe, Tomás Cruz, James P Bohnslav, David A Yarmolinsky
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a40a617760c272491d2595e312df16
https://doi.org/10.7554/elife.63377
https://doi.org/10.7554/elife.63377
Autor:
Christopher D. Harvey, Clifford J. Woolf, David A Yarmolinsky, Lauren L. Orefice, M. Eugenia Chiappe, Nivanthika K Wimalasena, Kelsey J Clausing, Tomás Cruz, James P Bohnslav, Yu Y Dai, Adam D Kashlan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a9150081598d34e2a2c221246f5e81
https://doi.org/10.7554/elife.63377.sa2
https://doi.org/10.7554/elife.63377.sa2
Autor:
Christopher D. Harvey, Clifford J. Woolf, Masakazu Kotoda, Sandeep Robert Datta, Rafael Gonzalez-Cano, Bruno Boivin, David Roberson, Lee Barrett, Victor Fattori, Alexander B. Wiltschko, Zihe Zhang, David A Yarmolinsky, James P Bohnslav, Daniel Taub, Shay Q. Neufeld, Nivanthika K Wimalasena, Nara L. M. Quintão
Publikováno v:
SSRN Electronic Journal.
SUMMARYThe lack of robust quantifiable behavioral assessments of pain in pre-clinical models, especially of ongoing pain, has been a major limitation for both pain neurobiology research and development of novel analgesics. Current methods typically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91495c40bb829531409b4bc8d78b4b9
https://doi.org/10.2139/ssrn.3793964
https://doi.org/10.2139/ssrn.3793964
Autor:
Christopher D. Harvey, Clifford J. Woolf, James P Bohnslav, Tomás Cruz, Kelsey J Clausing, Lauren L. Orefice, eugenia chiappe, David A Yarmolinsky, Nivanthika K Wimalasena
Researchers commonly acquire videos of animal behavior and quantify the prevalence of behaviors of interest to study nervous system function, the effects of gene mutations, and the efficacy of pharmacological therapies. This analysis is typically per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59c910378ca828995ccb550a47635ff
https://doi.org/10.1101/2020.09.24.312504
https://doi.org/10.1101/2020.09.24.312504
Autor:
Nivanthika K Wimalasena, Stephen G. Waxman, Catharina G. Faber, Clifford J. Woolf, Giuseppe Lauria, Lubin Chen, Rafael Gonzalez-Cano, Jaehoon Shim, Sulayman D. Dib-Hajj, Seong-il Lee, Mark Estacion, Chongyang Han
Publikováno v:
Pain
Pain, 162(6), 1758-1770. LIPPINCOTT WILLIAMS & WILKINS
Pain, 162(6), 1758-1770. LIPPINCOTT WILLIAMS & WILKINS
Small-fiber neuropathy (SFN), characterized by distal unmyelinated or thinly myelinated fiber loss, produces a combination of sensory dysfunction and neuropathic pain. Gain-of-function variants in the sodium channel Na(v)1.7 that produce dorsal root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149775710eee8cd244f3baf4cd7937a
https://pubmed.ncbi.nlm.nih.gov/33323889
https://pubmed.ncbi.nlm.nih.gov/33323889
Autor:
George Milner, Diana M. Bautista, Cliff Vuong, Nivanthika K Wimalasena, Ricardo Silva, Clifford J. Woolf, Zihe Zhang
Publikováno v:
Neuron
Neuron, vol 109, iss 19
Neuron, vol 109, iss 19
SUMMARY Itch is a discrete and irritating sensation tightly coupled to a drive to scratch. Acute scratching developed evolutionarily as an adaptive defense against skin irritants, pathogens, or parasites. In contrast, the itch-scratch cycle in chroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1a82a3aeffb7f6830d38c1ef35e0a2
http://europepmc.org/articles/PMC8497439
http://europepmc.org/articles/PMC8497439
Autor:
Rakesh Karmacharya, Viet Q. Le, Stuart L. Schreiber, Kandatege Wimalasena, Nivanthika K Wimalasena
Publikováno v:
ACS Chemical Neuroscience. 7:857-863
We carried out a gene expression-based in silico screen in order to identify small molecules with gene-expression profiles that are anticorrelated with a gene-expression profile for Parkinson's disease (PD). We identified the cyclin-dependent kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d90a699525d07b3565c99b4a838f99
https://doi.org/10.1021/acschemneuro.6b00076
https://doi.org/10.1021/acschemneuro.6b00076