Výsledky vyhledávání

Safety and efficacy of VB-111, an anticancer gene therapy, in patients with recurrent glioblastoma: results of a phase I/II study

Autor: Timothy F. Cloughesy, Laurence S. Freedman, Felix Bokstein, Benjamin M. Ellingson, Andrew Brenner, Katherine B. Peters, Naamit Sher, Eyal Breitbart, Shlomit Yust-Katz, Patrick Y. Wen, Itzhak Mendel, Bernice Oberman, Idit Peretz, Tamar Rachmilewitz Minei, Niva Yakov, James J. Vredenburgh, Deborah T. Blumenthal, Yael C Cohen, Noa Lowenton-Spier

Publikováno v: Neuro-oncology, vol 22, iss 5
Neuro-Oncology

Background VB-111 is a non-replicating adenovirus carrying a Fas-chimera transgene, leading to targeted apoptosis of tumor vascular endothelium and induction of a tumor-specific immune response. This phase I/II study evaluated the safety, tolerabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46c0464ac87173392444905e4373dc6
https://escholarship.org/uc/item/269665k9

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Abstract 4979: Ofranergene Obadenovec (VB-111), an anti-cancer gene therapy, induces immunologic responses in solid tumors transforming cold tumors to hot tumors

Autor: Ronnie Shapira-Frommer, Tamar Rachmilewitz Minei, Iris Barshack, Itzhak Mendel, Niva Yakov, Yael C. Cohen, Eyal Breitbart, Dror Harats, Richard T. Penson

Publikováno v: Cancer Research. 79:4979-4979

Introduction: Ofranergene Obadenovec (VB-111) is a non-replicating adenovirus 5 (Ad-5, El-deleted) carrying a proapoptotic human Fas-chimera transgene that targets angiogenic blood vessels and leads to vascular disruption. Improved responses seen amo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbca8db2bd57f61bc6f6800af76dd20a
https://doi.org/10.1158/1538-7445.am2019-4979

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Ofranergene obadenovec (VB-111) an anti-cancer gene therapy induces immunotherapeutic effect in platinum resistant ovarian cancer: Histopathology findings

Autor: Iris Barshack, Bradley J. Monk, T. Rachmilewitz Minei, Niva Yakov, Yonatan Cohen, Richard T. Penson, Ronnie Shapira-Frommer

Publikováno v: Gynecologic Oncology. 154:231-232

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ae4f02d4a05e94b59b2036cacb544fb
https://doi.org/10.1016/j.ygyno.2019.04.537

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Deficiency of Antigen-Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

Autor: Dror Harats, Karsten Hartvigsen, Hidde Ploegh, Galina K. Sukhova, Peter Libby, Guo-Ping Shi, Jacob George, Joseph L. Witztum, Yadong Zhang, Jiusong Sun, Meng-Yun Chou, Cody J. Diehl, Jie Zhang, Marco Lopez-Ilasaca, Niva Yakov

Publikováno v: PMC

August 25, 2010
Background: Adaptive immunity and innate immunity play important roles in atherogenesis. Invariant chain (CD74) mediates antigen-presenting cell antigen presentation and T-cell activation. This study tested the hypothesis that CD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050377d556ecb030bbbe385a3a503a92
https://doi.org/10.1161/circulationaha.109.891887

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VB-111: A novel anti-vascular therapeutic for glioblastoma multiforme

Autor: Livnat Bangio, Anu Soundararajan, David Cavazos, Eyal Breitbart, Jessica R. Miller, Niva Yakov, Yael C Cohen, Aleksandra Gruslova, Andrew Brenner, John Floyd

Glioblastoma multiforme (GBM) is among the most highly vascularized of solid tumors, contributing to the infiltrative nature of the disease, and conferring poor outcome. Due to the critical dependency of GBM on growth of new endothelial vasculature,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9eb48ff06d3c19a2f41a463bf7a4208
https://europepmc.org/articles/PMC4584173/

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