Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Niv Papo"'
Autor:
Amiram Sananes, Itay Cohen, Irit Allon, Oshrit Ben‐David, Raghda Abu Shareb, Ksenia M. Yegodayev, David Stepensky, Moshe Elkabets, Niv Papo
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2337-2355 (2023)
Targeted therapies for prostate, breast, and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process. Emerg
Externí odkaz:
https://doaj.org/article/a4cefe3f8f3c47aea4beb5cc1ffd954a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Cancer progression is enhanced by the interaction of programmed death-ligand 1 (PDL1), which is associated with inhibition of the immune response against tumors, and vascular endothelial growth factor (VEGF), which inhibits immune cell activ
Externí odkaz:
https://doaj.org/article/1debb6eaf8674daf9095bf842ddbbef5
Autor:
Hezi Hayun, Matt Coban, Ashok Kumar Bhagat, Eden Ozer, Lital Alfonta, Thomas R. Caulfield, Evette S. Radisky, Niv Papo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Matrix metalloproteinases (MMPs) regulate the degradation of extracellular matrix (ECM) components in biological processes. MMP activity is controlled by natural tissue inhibitors of metalloproteinases (TIMPs) that non-selectively inhibit th
Externí odkaz:
https://doaj.org/article/9302df7774f5463d897a9547d6d88c2a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The immense potential of G protein-coupled receptors (GPCRs) as targets for drug discovery is not fully realized due to the enormous difficulties associated with structure elucidation of these profoundly unstable membrane proteins. The exist
Externí odkaz:
https://doaj.org/article/9fc1cad6e82442238577b904e41dd1f9
Autor:
Eitan Rabinovitch, Koishiro Mihara, Amiram Sananes, Marianna Zaretsky, Michael Heyne, Julia Shifman, Amir Aharoni, Morley D. Hollenberg, Niv Papo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis. The PAR1 transmembrane G-protein-coupled
Externí odkaz:
https://doaj.org/article/1a0212dd91364948b979eba1d92f904e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Quantifying the effect of mutations on binding free energy is important to understand protein-protein interaction (PPI). Here the authors develop a method based on yeast display and next-generation sequencing to generate quantitative binding landscap
Externí odkaz:
https://doaj.org/article/30d06668541b438abf2226ef9ab7a880
Autor:
Shiran Lacham-Hartman, Yulia Shmidov, Evette S Radisky, Ronit Bitton, David B Lukatsky, Niv Papo
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0249616 (2021)
Although myriad protein-protein interactions in nature use polyvalent binding, in which multiple ligands on one entity bind to multiple receptors on another, to date an affinity advantage of polyvalent binding has been demonstrated experimentally onl
Externí odkaz:
https://doaj.org/article/85fd5f0416b848ddb4bd776b3283d717
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of protein
Externí odkaz:
https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-18 (2018)
Abstract Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by
Externí odkaz:
https://doaj.org/article/594a823a68e64e799fd4bc38b57d1a91
Autor:
Juliana B. Candido, Oscar Maiques, Melanie Boxberg, Verena Kast, Eleonora Peerani, Elena Tomás-Bort, Wilko Weichert, Amiram Sananes, Niv Papo, Viktor Magdolen, Victoria Sanz-Moreno, Daniela Loessner
Publikováno v:
Cancers, Vol 13, Iss 16, p 3969 (2021)
As cancer-associated factors, kallikrein-related peptidases (KLKs) are components of the tumour microenvironment, which represents a rich substrate repertoire, and considered attractive targets for the development of novel treatments. Standard-of-car
Externí odkaz:
https://doaj.org/article/133f4676a7f1468ca1ba41286ec7ce24