Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Niu Shin"'
Autor:
Verena Vonwirth, Yagmur Bülbül, Anke Werner, Hakim Echchannaoui, Johannes Windschmitt, Alice Habermeier, Sonia Ioannidis, Niu Shin, Roland Conradi, Matthias Bros, Stefan Tenzer, Matthias Theobald, Ellen Ildicho Closs, Markus Munder
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear
Externí odkaz:
https://doaj.org/article/0daad00354a64a40a3692ca2c702f449
Autor:
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Kathy Wang, Maryanne Covington, Cindy Marando, Kevin Bowman, Jason Boer, Krista Burke, Richard Wynn, Alex Margulis, Gary W Reuther, Que T Lambert, Valerie Dostalik Roman, Ke Zhang, Hao Feng, Chu-Biao Xue, Sharon Diamond, Greg Hollis, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Kris Vaddi, Peggy Scherle
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199108 (2018)
The Proviral Integration site of Moloney murine leukemia virus (PIM) serine/threonine protein kinases are overexpressed in many hematologic and solid tumor malignancies and play central roles in intracellular signaling networks important in tumorigen
Externí odkaz:
https://doaj.org/article/171a9a5db0614099bf5185681e8619f9
Autor:
Diana A. Arias, Stephen Douglass, Lisa Truong, Qian Wang, Kathy H. Wang, Gengjie Yang, Michael Hansbury, Sybil O’Connor, Kevin Bowman, Robert Collins, Matthew Stubbs, Leslie Hall, Christina Stevens, Christopher Maddage, Brent Douty, Maryanne Covington, Lynn Leffet, Eddy Yue, Andrew Combs, Sunkyu Kim, Niu Shin, Holly Koblish, Rodrigo Hess
Publikováno v:
Cancer Research. 83:5162-5162
Immune checkpoint blockade has shown impressive efficacy in patients with inflamed tumors, although minimal activity has been observed in tumors lacking T cells. Myeloid cells are one of the most abundant cell types in both inflamed and non-inflamed
Autor:
Qian Wang, Sybil O'Connor, Alan Roberts, Brian W. Metcalf, Leslie Hall, Maxim Soloviev, Michael Hansbury, Greg Hollis, Xin He, Matthew C. Stubbs, Niu Shin, Wenqing Yao, Kamna Katiyar, Phillip C.C. Liu, Kathy Wang, Sharon Diamond, Brent Douty, Gengjie Yang, Dana Shuey, Maryanne B. Covington, Paul Collier, Mingming Gao, Patricia Feldman, Peggy Scherle, Timothy Burn, Andrew P. Combs, Yun-Long Li, Lynn Leffet, Robert C. Newton, Paul Waeltz, Holly Koblish, Jin Lu, Swamy Yeleswaram, Yanlong Li, Reid Huber, Robert Collins, Eddy W. Yue
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:211-222
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, and/or discontinuation of therapy. In addition, potential molec
Autor:
Andrew P Combs, Niu Shin, Laurine Galya, James Hall, Sharon Diamond, Kevin Baptiste, Jason Boer, Yan-ou Yang, Kevin J Bowman, Maryanne B Covington, Yanlong Li, Xin He, Daniel Levy, Brent D Douty, Padmaja Polam, David M Burns, Artem Shvartsbart, Eddy W Yue, Rick Sparks, Nikoo Falahatpisheh, Lixin Shao, Stacey Shepard, Andrew W Buesking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9b46276e455cc32362364091e1119
https://doi.org/10.1021/scimeetings.0c06483
https://doi.org/10.1021/scimeetings.0c06483
Autor:
Niu, Shin, Matthew, Stubbs, Holly, Koblish, Eddy W, Yue, Maxim, Soloviev, Brent, Douty, Kathy He, Wang, Qian, Wang, Mingming, Gao, Patricia, Feldman, Gengjie, Yang, Leslie, Hall, Michael, Hansbury, Sybil, O'Connor, Lynn, Leffet, Robert, Collins, Kamna, Katiyar, Xin, He, Paul, Waeltz, Paul, Collier, Jin, Lu, Yun-Long, Li, Yanlong, Li, Phillip C C, Liu, Timothy, Burn, Maryanne, Covington, Sharon, Diamond, Dana, Shuey, Alan, Roberts, Swamy, Yeleswaram, Greg, Hollis, Brian, Metcalf, Wenqing, Yao, Reid, Huber, Andrew, Combs, Robert, Newton, Peggy, Scherle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 374(1)
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)
Autor:
Sharon Diamond, Kamna Katiyar, Qian Wang, Andrew P. Combs, Holly Koblish, Gengjie Yang, Jordan S. Fridman, Maryanne B. Covington, Gregory Hollis, Yanlong Li, Jun Li, Swamy Yeleswaram, Xin He, Reid Huber, Yun-Long Li, Lynn Leffet, Mark Rupar, Kathy Wang, Dana Shuey, Wenqing Yao, Leslie Hall, Maxim Soloviev, Kevin Bowman, Robert C. Newton, Mike Liu, Margaret F. Favata, Peggy Scherle, Timothy Burn, Kris Vaddi, Beth Rumberger, Song Mei, Niu Shin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 364:120-130
Phosphatidylinositol 3-kinase delta (PI3Kδ) is a critical signaling molecule in B cells and is considered a target for development of therapies against various B cell malignancies. INCB040093 is a novel PI3Kδ small-molecule inhibitor and has demons
Autor:
Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] A medicinal chemistry effort focused on identifying a structurally diverse candidate for phosphoinositide 3-kinase delta (PI3Kδ) led to the discovery of clinical candidate INCB050465 (20, parsaclisib). The unique structure of 20 co
Autor:
Niu Shin, Yan-Ou Yang, Eddy W. Yue, Monika Scuron, Eduardo Huarte, Paul Smith, Melissa Parker, Brittany Fay, Andrew P. Combs
Publikováno v:
Poster Presentations.
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, including the skin, joints and kidneys. Though SLE typically cycles through periods of flares and remission, patients often eventually succumb to en
Autor:
Sharon Diamond, Taisheng Huang, Karen Gallagher, Jun Li, Brittany Fay, Monika Scuron, Michael Peel, Robert C. Newton, Niu Shin, Ashish Juvekar, Peggy Scherle, Xin He, Julian Oliver, Robert Collins, Chu-Biao Xue, Krista Burke, Yan Zhang, Paul Smith, Wenqing Yao, Maryanne Covington, Margaret Favata, Sarala Sarah
Publikováno v:
European Journal of Pharmacology. 885:173505
Pharmacological modulation of the Janus kinase (JAK) family has achieved clinically meaningful therapeutic outcomes for the treatment of inflammatory and hematopoietic diseases. Several JAK1 selective compounds are being investigated clinically to de