Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nitza Ilan"'
Publikováno v:
Journal of Biological Chemistry. 282:29424-29430
Gating modifiers of voltage-gated sodium channels (Na(v)s) are important tools in neuroscience research and may have therapeutic potential in medicinal disorders. Analysis of the bioactive surface of the scorpion beta-toxin Css4 (from Centruroides su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7067fcdcb3ea7fd19f3a67a22ea03595
https://doi.org/10.1074/jbc.m704651200
https://doi.org/10.1074/jbc.m704651200
Autor:
Maya Gur, Michael Gurevitz, Nitza Ilan, Gerardo Corzo, Stefan H. Heinemann, Oren Froy, Roy Kahn, Nicolas Gilles, Gudrun Albrecht, Izhar Karbat, Lior Cohen, Dalia Gordon
Publikováno v:
FEBS Journal. 274:1918-1931
The affinity of scorpion α-toxins for various voltage-gated sodium channels (Navs) differs considerably despite similar structures and activities. It has been proposed that key bioactive residues of the five-residue-turn (residues 8–12) and the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14110ba7ecb5637bc8dfb1d5e87f7c98
https://doi.org/10.1111/j.1742-4658.2007.05737.x
https://doi.org/10.1111/j.1742-4658.2007.05737.x
Autor:
Lior Cohen, Roy Kahn, Walter Stühmer, Michael Turkov, Nitza Ilan, Dalia Gordon, Ke Dong, Izhar Karbat, Michael Gurevitz, Maria Stankiewicz
Publikováno v:
Toxicon. 49:473-489
Voltage-gated sodium channels are a major target for toxins and insecticides due to their central role in excitability, but due to the conservation of these channels in Animalia most insecticides do not distinguish between those of insects and mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b8de9354014ec7709cc8dde1a02a64
https://doi.org/10.1016/j.toxicon.2006.11.015
https://doi.org/10.1016/j.toxicon.2006.11.015
Autor:
Nitza Ilan, Jan Tytgat, Ke Dong, Izhar Karbat, Nicolas Gilles, Walter Stühmer, Dalia Gordon, Michael Gurevitz, Roy Kahn, Lior Cohen
Publikováno v:
Toxicon. 49:452-472
Receptor site-3 on voltage-gated sodium channels is targeted by a variety of structurally distinct toxins from scorpions, sea anemones, and spiders whose typical action is the inhibition of sodium current inactivation. This site interacts allosterica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5888d09be66f32015bfb9fbd0c72ac79
https://doi.org/10.1016/j.toxicon.2006.11.016
https://doi.org/10.1016/j.toxicon.2006.11.016
Autor:
Marcel Pelhate, Nicolas Gilles, Nitza Ilan, Dalia Gordon, Lior Cohen, Maria Stankiewicz, Michael Turkov, Noam Zilberberg, David Strugatsky, Michael Gurevitz
Publikováno v:
Biochemistry. 44:9179-9187
We isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus an extremely active anti-insect selective depressant toxin, Lqh-dprIT(3). Cloning of Lqh-dprIT(3) revealed a gene family encoding eight putative polypeptide variants (a-h) di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850e6338df94fcb2d7fedebeea94f630
https://doi.org/10.1021/bi050235t
https://doi.org/10.1021/bi050235t
Autor:
Noam Zilberberg, Roland G. Kallen, Michael Gurevitz, Nitza Ilan, Nicolas Gilles, Oren Froy, Lior Cohen, Daniel Urbach, Izhar Karbat, Morris Benveniste, Ariel Gaathon, Dalia Gordon
Publikováno v:
European Journal of Biochemistry. 270:2663-2670
Scorpion toxins that affect sodium channel (NaCh) gating in excitable cells are divided into alpha- and beta-classes. Whereas alpha-toxins have been found in scorpions throughout the world, anti-mammalian beta-toxins have been assigned, thus far, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a1333a03bf93985832e76ced4bc2fc2
https://doi.org/10.1046/j.1432-1033.2003.03643.x
https://doi.org/10.1046/j.1432-1033.2003.03643.x
Autor:
Nitza Ilan, Dodo Chikashvili, Eliahu Zlotkin, Iris Shichor, Ilana Lotan, Walter Stühmer, Dalia Gordon
Publikováno v:
The Journal of Neuroscience. 22:4364-4371
The ability of the excitatory anti-insect-selective scorpion toxin AahIT (Androctonus australis hector) to exclusively bind to and modify the insect voltage-gated sodium channel (NaCh) makes it a unique tool to unravel the structural differences betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3e0a793292920f7608fa66094eead
https://doi.org/10.1523/jneurosci.22-11-04364.2002
https://doi.org/10.1523/jneurosci.22-11-04364.2002
Publikováno v:
Neuron. 32(4):635-648
Essential to nerve and muscle function, little is known about how potassium leak channels operate. KCNKO opens and closes in a kinase-dependent fashion. Here, the transition is shown to correspond to changes in the outer aspect of the ion conduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa989e2d74ef6b61ed60532dd756316
Publikováno v:
The Journal of General Physiology
Potassium-selective leak channels control neuromuscular function through effects on membrane excitability. Nonetheless, their existence as independent molecular entities was established only recently with the cloning of KCNKO from Drosophila melanoga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8961f4b168c359914a4814516a379dd9
https://doi.org/10.1085/jgp.116.5.721
https://doi.org/10.1085/jgp.116.5.721
Autor:
Nitza Ilan, Steve A.N. Goldstein, Stephen L. Sturley, Federico Sesti, Theodore M. Shih, Atique U. Ahmed
Publikováno v:
Cell. 99:283-291
Killer strains of S. cerevisiae harbor double-stranded RNA viruses and secrete protein toxins that kill virus-free cells. The K1 killer toxin acts on sensitive yeast cells to perturb potassium homeostasis and cause cell death. Here, the toxin is show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707c1ac5c33c869ce9b3877f8a6c9c7f
https://doi.org/10.1016/s0092-8674(00)81659-1
https://doi.org/10.1016/s0092-8674(00)81659-1