Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.

Autor: Megane Penalva YC; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 2B4.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1.; Centre de Recherche en Biologie Structurale (CRBS), McGill University, Montréal H3G 0B1, Québec, Canada., Paschkowsky S; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Recinto SJ; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 2B4.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1., Cinkorpumin J; Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 0B1., Hernandez MR; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 2B4.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1.; Centre de Recherche en Biologie Structurale (CRBS), McGill University, Montréal H3G 0B1, Québec, Canada., Xiao B; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 2B4.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1.; Centre de Recherche en Biologie Structurale (CRBS), McGill University, Montréal H3G 0B1, Québec, Canada., Nitu A; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada H3A 2B4.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1.; Centre de Recherche en Biologie Structurale (CRBS), McGill University, Montréal H3G 0B1, Québec, Canada., Yee-Li Wu H; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1., Munter HM; Department of Human Genetics, McGill University, Montreal, QC, Canada H3A 0C7., Michalski B; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada., Fahnestock M; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada., Pastor W; Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 0B1., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA., Munter LM; Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H3G 0B1.; Cell Information Systems group, Bellini Life Sciences Complex, McGill University, Montreal, QC, Canada H3G 0B1.; Centre de Recherche en Biologie Structurale (CRBS), McGill University, Montréal H3G 0B1, Québec, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.