Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Nitrocamptothecin"'
Autor:
Xiaohan Kou, Ziming Wang, Tao Yu, Zhiwei Hu, Zijia Wang, Qiang Zhang, Jian Zheng, Yang Wang, Changmin Shao, Zhisong Cao
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 179
9-Nitrocamptothecin-20-O-propionate (CZ112) and 9-Nitrocamptothecin (9NC) are the bioactive derivatives of camptothecin (CPT), an alkaloid isolated from Camptotheca acuminata, and have been confirmed to possess high anti-cancer properties. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a6c077ef4f11e9c32ed995d15cab65
https://pubmed.ncbi.nlm.nih.gov/31848079
https://pubmed.ncbi.nlm.nih.gov/31848079
Publikováno v:
Drug Delivery. 23:3417-3423
Although nanocarriers provide promising potential for oral drug delivery, the delivery efficiency remains unsatisfactory and needs to be improved. Size is considered to be the most important characteristic of nanoparticles related to their oral absor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067d2325701a02a222fddeaa068b8c9a
https://doi.org/10.1080/10717544.2016.1189466
https://doi.org/10.1080/10717544.2016.1189466
Publikováno v:
Research in Pharmaceutical Sciences
Scopus-Elsevier
Scopus-Elsevier
Ovarian cancer is the fifth leading cause of the cancer-related death among women. 9-nitrocamptothecin (9-NC) is a water-insoluble derivative of camptothecin used for the treatment of patients with advanced ovarian cancer. Previous studies showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4cf665280f1f2b02a2507791b4fd26b1
http://europepmc.org/articles/PMC4584455
http://europepmc.org/articles/PMC4584455
Publikováno v:
International Journal of Pharmaceutics. 477:399-407
Our study aimed to develop an amorphous 9-nitrocamptothecin solid dispersion (9-NC-SD) using polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus(®)) for improving its oral bioavailability and antitumor efficacy in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54902b1b13eeb478767bbf9cfe70d93
https://doi.org/10.1016/j.ijpharm.2014.10.055
https://doi.org/10.1016/j.ijpharm.2014.10.055
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3653-3665
Solid-state properties and physicochemical characteristics of 9-nitrocamptothecin (9NC) were investigated with a view of molecular and bulk level understanding of its poor aqueous solubility and hydrolytic instability that prevent efficient drug deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e9911d24f50b775bde29589586eb3b
https://doi.org/10.1002/jps.23671
https://doi.org/10.1002/jps.23671
Publikováno v:
Pharmaceutical Nanotechnology. 1:115-125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c714ae627ac7aa4845306612356bf9e6
https://doi.org/10.2174/2211738511301020007
https://doi.org/10.2174/2211738511301020007
Autor:
Zhongling Zhu, Zhao Yan, Chun Huang, Meijun Liu, Liuchun Wang, Peng Chen, Jinhuai Xue, Kai Li
Publikováno v:
Cancer Chemotherapy and Pharmacology. 67:955-961
9-Nitrocamptothecin (9-NC) is a novel orally administered camptothecin analog. The purpose of this study is to evaluate the pharmacokinetics and safety of 9-nitrocamptothecin in patients with advanced solid tumors.The 23 patients for a single-dose ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1ee0aac1df949c52940af400a72a08
https://doi.org/10.1007/s00280-010-1546-z
https://doi.org/10.1007/s00280-010-1546-z
Publikováno v:
International Journal of Chemical Kinetics. 42:693-703
Kinetic and thermodynamic analysis of the 9-nitrocamptothecin (9NC) hydrolysis reaction in the presence and absence of human serum albumin (HSA) in phosphate-buffered saline (PBS) of pH 7.4 was carried out by first derivative absorption spectroscopy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3907307333eae671baede3adf939c186
https://doi.org/10.1002/kin.20508
https://doi.org/10.1002/kin.20508
Autor:
Panayotis Pantazis, Beppino C. Giovanella, Donald Kufe, Albert DeJesus, John Mendoza, Eric H. Rubin
Publikováno v:
European Journal of Haematology. 53:135-144
Human leukemia U-937 cell sublines exhibiting various levels of resistance to 9-nitrocamptothecin (9NC) were developed after exposure to progressively increased 9NC concentrations. Increases in 9NC resistance of the cells were accompanied by decrease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b661ddc5b6e16c6df51bf2086cb54a
https://doi.org/10.1111/j.1600-0609.1994.tb00661.x
https://doi.org/10.1111/j.1600-0609.1994.tb00661.x
Autor:
Fei Xu, Jie Dong, Xueqin Yang, Jun Chen, Shanshan Lu, Pei Peng, Zheyun Xiong, Wei Gu, Xi-Xiong Yang
Publikováno v:
International journal of pharmaceutics. 490(1-2)
Encapsulation of hydrophobic drugs in the form of drug-cyclodextrin (CD) complex in liposomes has been applied as a novel strategy to combine the relative advantages of CDs and liposomes into one system, naming drug-in-CD-in-liposome (DCL). In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81d66f14145cc6e5b68234ee11b9bc9
https://pubmed.ncbi.nlm.nih.gov/26004006
https://pubmed.ncbi.nlm.nih.gov/26004006