Výsledky vyhledávání - "Nitriles/pharmacology"

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

Autor: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

Publikováno v: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373

SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf

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Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth

Autor: Roberto Montesano

Publikováno v: Biochemical and Biophysical Research Communications, Vol. 353, No 3 (2007) pp. 817-22

Bone morphogenetic proteins (BMPs) are multifunctional cytokines that regulate key developmental processes, but are also overexpressed in many carcinomas. To assess whether BMPs would influence the three-dimensional architecture of epithelial structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdd5b715a52d99783c7f0307b57e08f
https://doi.org/10.1016/j.bbrc.2006.12.109

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Ejaculatory sperm production in non-obstructive azoospermic patients with a history of negative testicular biopsy after the administration of an aromatase inhibitor

Autor: Paul Devroey, Biljana Popovic-Todorovic, P. Donoso, H.M. Fatemi, Ioannis P. Kosmas, D. Kyrou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b9ea5312578b5300066c6fe99f06f3
https://hdl.handle.net/20.500.14017/e2d38448-eb88-4db4-aff0-becedf65d180

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Stretch-induced inhibition of Wnt/beta-catenin signaling in mineralizing osteoblasts

Autor: Jansen, Justus H W, Eijken, Marco, Jahr, Holger, Chiba, Hideki, Verhaar, Jan A N, van Leeuwen, Johannes P T M, Weinans, Harrie

Publikováno v: Jansen, J H W, Eijken, M, Jahr, H, Chiba, H, Verhaar, J A N, van Leeuwen, J P T M & Weinans, H 2010, ' Stretch-induced inhibition of Wnt/beta-catenin signaling in mineralizing osteoblasts ', Journal of Orthopaedic Research, vol. 28, no. 3, pp. 390-6 . https://doi.org/10.1002/jor.20991

Wnt signaling is important for bone formation and osteoblastic differentiation. Recent findings indicate a stimulating role of Wnt signaling in bone mechanotransduction. However, negative effects of Wnt signaling on osteoblast differentiation and min

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::146772e100c150097a40c592dfc1b6a0
https://pure.au.dk/portal/da/publications/stretchinduced-inhibition-of-wntbetacatenin-signaling-in-mineralizing-osteoblasts(19b44743-284b-4524-9d05-29762dcf27e3).html

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Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression

Autor: Paolo Pugnale, Eric Féraille, Roberto Montesano, Fabio Carrozzino

Publikováno v: American Journal of Physiology. Cell Physiology, Vol. 297, No 3 (2009) pp. C775-87

Tight junctions (TJs) form a barrier to the paracellular diffusion of ions and solutes across epithelia. Although transmembrane proteins of the claudin family have emerged as critical determinants of TJ permeability, little is known about the signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453f024512e3f78cbb5380fb7b213b92
https://pubmed.ncbi.nlm.nih.gov/19605737

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High-content classification of nucleocytoplasmic import or export inhibitors

Autor: Hi Chul Kim, Sungyong Jung, Auguste Genovesio, Ulf Nehrbass, Brigitte David-Watine, Neil Emans, Nam Youl Kim, Yong-Jun Kwon

Publikováno v: Journal of Biomolecular Screening
Journal of Biomolecular Screening, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Journal of Biomolecular Screening, SAGE Publications, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩

Transcription factors of the nuclear factor κ B family are the paradigm for signaling dependent nuclear translocation and are ideally suited to analysis through image-based chemical genetic screening. The authors describe combining high-content imag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04185305487563cc4986d45255f3060
https://pubmed.ncbi.nlm.nih.gov/17507639

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Activation of NF-kappaB by extracellular matrix is involved in spreading and glucose-stimulated insulin secretion of pancreatic beta cells

Autor: Jean-Claude Irminger, Dominique G. Rouiller, Philippe A. Halban, Géraldine Parnaud, Domenico Bosco, Katharina Rickenbach, Pascale Ribaux, Eva Hammar

Publikováno v: Journal of Biological Chemistry, Vol. 280, No 34 (2005) pp. 30630-30637

Laminin-5-rich extracellular matrix derived from 804G cells (804G-ECM) engages beta1 integrins to induce spreading, improve glucose-stimulated insulin secretion (GSIS), and increase survival of pancreatic beta cells. The present study examines whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09318b5da2dd66f413ba4c37a8794f0c
https://archive-ouverte.unige.ch/unige:8794

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Apoptosis and TRAF-1 cleavage in Epstein-Barr virus-positive nasopharyngeal carcinoma cells treated with doxorubicin combined with a farnesyl-transferase inhibitor

Autor: Hector Ardila-Osorio, Abdelmajid Khabir, Rachid Jlidi, Marie C. Brezak, Philip G. Kasprzyk, Tadamassa Ooka, Isabelle Viossat, Jean Michel Vicat, Gregoire Prevost, Paule Opolon, Philippe Busson, Dolly P. Huang

Publikováno v: Europe PubMed Central

Epstein-Barr virus (EBV)-associated nasopharyngeal carcinomas (NPC) are much more sensitive to chemotherapy than other head and neck carcinomas. Spectacular regressions are frequently observed after induction chemotherapy. However, these favorable re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f221ec1490c53b4f3d345cc5721bcb
http://europepmc.org/abstract/med/12527335

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