Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nitric Oxide Synthase Type I/genetics"'
Autor:
Konstantina Chachlaki, Andrea Messina, Virginia Delli, Valerie Leysen, Csilla Maurnyi, Chieko Huber, Gaëtan Ternier, Katalin Skrapits, Georgios Papadakis, Sonal Shruti, Maria Kapanidou, Xu Cheng, James Acierno, Jesse Rademaker, Sowmyalakshmi Rasika, Richard Quinton, Marek Niedziela, Dagmar L’Allemand, Duarte Pignatelli, Mirjam Dirlewander, Mariarosaria Lang-Muritano, Patrick Kempf, Sophie Catteau-Jonard, Nicolas J. Niederländer, Philippe Ciofi, Manuel Tena-Sempere, John Garthwaite, Laurent Storme, Paul Avan, Erik Hrabovszky, Alan Carleton, Federico Santoni, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369
Science Translational Medicine, 2022, 14 (665), pp.eabh2369. ⟨10.1126/scitranslmed.abh2369⟩
Science translational medicine, vol. 14, no. 665, pp. eabh2369
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b9ba2a2f53ed6983bfc3208da7475d
https://www.hal.inserm.fr/inserm-03841246
https://www.hal.inserm.fr/inserm-03841246
Autor:
Emre Guney, Mahmoud H. Elbatreek, Harald H.H.W. Schmidt, Jan Baumbach, Javier Egea, Simon J. Larsen, Vanessa Gómez-Rangel, Ana I. Casas, Pamela W. M. Kleikers, Manuela G. López, Ahmed A. Hassan
Publikováno v:
Casas, A I, Hassan, A A, Larsen, S J, Gomez-Rangel, V, Elbatreek, M, Kleikers, P W M, Guney, E, Egea, J, López, M G, Baumbach, J & Schmidt, H H H W 2019, ' From single drug targets to synergistic network pharmacology in ischemic stroke ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7129-7136 . https://doi.org/10.1073/pnas.1820799116
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Current one drug–one target–one disease approaches in drug discovery have become increasingly inefficient. Network pharmacology defines disease mechanisms as networks best targeted by multiple, synergistic drugs. Using the high unmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd3be0432e66a4fc3c69b16682fec9
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf
Autor:
Niamh L. O'Brien, Francesco Lescai, Ditte Demontis, Jakob Grove, Jonatan Pallesen, Manuel Mattheisen, E Eickhardt, Thomas Damm Als, Qingqin S. Li, Jun-Jun Wang, J Liang, Anne Hedemand, Andrew McQuillin, Alex Jarram, Mette Nyegaard, Ole Mors, Alessia Fiorentino, Marjun Biskopstø, Gudrid Andorsdottir, Anders D. Børglum, August G. Wang, Lars Bolund
Publikováno v:
Translational Psychiatry
Lescai, F, Als, T D, Li, Q, Nyegaard, M, Andorsdottir, G, Biskopstø, M, Hedemand, A, Fiorentino, A, O'Brien, N, Jarram, A, Liang, J, Grove, J, Pallesen, J, Eickhardt, E, Mattheisen, M, Bolund, L, Demontis, D, Wang, A G, McQuillin, A, Mors, O, Wang, J & Børglum, A D 2017, ' Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder ', Translational Psychiatry, vol. 7, e1034 . https://doi.org/10.1038/tp.2017.3
Lescai, F, Als, T D, Li, Q, Nyegaard, M, Andorsdottir, G, Biskopstø, M, Hedemand, A, Fiorentino, A, O'Brien, N L, Jarram, A, Liang, T J, Grove, J, Pallesen, J, Eickhardt, E, Mattheisen, M, Bolund, L, Demontis, D, Wang, A G, McQuillin, A, Mors, O, Wang, J & Børglum, A D 2017, ' Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder ', Translational Psychiatry, vol. 7, no. 2, pp. e1034 . https://doi.org/10.1038/tp.2017.3
Lescai, F, Als, T D, Li, Q, Nyegaard, M, Andorsdottir, G, Biskopstø, M, Hedemand, A, Fiorentino, A, O'Brien, N, Jarram, A, Liang, J, Grove, J, Pallesen, J, Eickhardt, E, Mattheisen, M, Bolund, L, Demontis, D, Wang, A G, McQuillin, A, Mors, O, Wang, J & Børglum, A D 2017, ' Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder ', Translational Psychiatry, vol. 7, e1034 . https://doi.org/10.1038/tp.2017.3
Lescai, F, Als, T D, Li, Q, Nyegaard, M, Andorsdottir, G, Biskopstø, M, Hedemand, A, Fiorentino, A, O'Brien, N L, Jarram, A, Liang, T J, Grove, J, Pallesen, J, Eickhardt, E, Mattheisen, M, Bolund, L, Demontis, D, Wang, A G, McQuillin, A, Mors, O, Wang, J & Børglum, A D 2017, ' Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder ', Translational Psychiatry, vol. 7, no. 2, pp. e1034 . https://doi.org/10.1038/tp.2017.3
Bipolar disorder affects about 1% of the world’s population, and its estimated heritability is about 75%. Only few whole genome or whole-exome sequencing studies in bipolar disorder have been reported, and no rare coding variants have yet been robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d624b42c59dee0cf3b78f433922e7b11
https://pubmed.ncbi.nlm.nih.gov/28195573
https://pubmed.ncbi.nlm.nih.gov/28195573
Autor:
Stéphane Cook, Pierre Turini, Rémy Burcelin, Peter Vollenweider, Pierre-Yves Jayet, Pascal Nicod, Mathieu C, Claudio Sartori, Urs Scherrer, Thalmann S
Publikováno v:
Swiss Medical Weekly, vol. 137, no. 49-50, pp. 700-704
BACKGROUND: nitric oxide (NO) plays an important role in the regulation of cardiovascular and glucose homeostasis. Mice lacking the gene encoding the neuronal isoform of nitric oxide synthase (nNOS) are insulin-resistant, but the underlying mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f87944658f80172a225ab57f7b59ce
https://doi.org/10.4414/smw.2007.11950
https://doi.org/10.4414/smw.2007.11950