Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nitobe London"'
Autor:
Adrienne Barber, Nitobe London, Aimee J Littleton, Kwaku N. Opoku, Lori B. Koch, Yi Deng, Charles L. Asbury, Sue Biggins
Publikováno v:
Proceedings of the National Academy of Sciences. 116:17355-17360
Accurate mitosis depends on a surveillance system called the spindle assembly checkpoint. This checkpoint acts at kinetochores, which attach chromosomes to the dynamic tips of spindle microtubules. When a kinetochore is unattached or improperly attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1dce22cd8bd042ca3b5d3aa7447490
https://doi.org/10.1073/pnas.1901653116
https://doi.org/10.1073/pnas.1901653116
Autor:
Nitobe London, Sue Biggins
Publikováno v:
Nature Reviews Molecular Cell Biology. 15:736-748
The spindle checkpoint ensures proper chromosome segregation during cell division. Unravelling checkpoint signalling has been a long-standing challenge owing to the complexity of the structures and forces that regulate chromosome segregation. New rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc6fc1789dcf5d37098e293965635e1
https://doi.org/10.1038/nrm3888
https://doi.org/10.1038/nrm3888
Publikováno v:
Current Biology. 22:900-906
SummaryKinetochores are the macromolecular complexes that interact with microtubules to mediate chromosome segregation [1]. Accurate segregation requires that kinetochores make bioriented attachments to microtubules from opposite poles. Attachments b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed916635ea22166a6201d78e1a74d4ec
https://doi.org/10.1016/j.cub.2012.03.052
https://doi.org/10.1016/j.cub.2012.03.052
Autor:
Kevin G. Hardwick, Lucile Grzesiak, Yingrui Ma, Ioanna Leontiou, Bethan Medina-Pritchard, Karen M. May, Sue Biggins, A. Arockia Jeyaprakash, Priya Amin, Nitobe London
Publikováno v:
Current Biology
Leontiou, I, London, N, May, K M, Ma, Y, Grzesiak, L, Medina-Pritchard, B, Amin, P, Jeyaprakash, A A, Biggins, S & Hardwick, K G 2019, ' The Bub1-TPR domain interacts directly with Mad3 to generate robust spindle checkpoint arrest ', Current biology : CB, vol. 29, no. 14 . https://doi.org/10.1016/j.cub.2019.06.011
Leontiou, I, London, N, May, K M, Ma, Y, Grzesiak, L, Medina-Pritchard, B, Amin, P, Jeyaprakash, A A, Biggins, S & Hardwick, K G 2019, ' The Bub1-TPR domain interacts directly with Mad3 to generate robust spindle checkpoint arrest ', Current biology : CB, vol. 29, no. 14 . https://doi.org/10.1016/j.cub.2019.06.011
Summary The spindle checkpoint monitors kinetochore-microtubule interactions and generates a “wait anaphase” delay when any defects are apparent [1, 2, 3]. This provides time for cells to correct chromosome attachment errors and ensure high-fidel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d49e76cc5a8301e3ad09e86f23da1c
http://europepmc.org/articles/PMC6657678
http://europepmc.org/articles/PMC6657678
Publikováno v:
Development. 135:3665-3675
Anteroposterior polarity in early C. elegans embryos is required for the specification of somatic and germline lineages, and is initiated by a sperm-induced reorganization of the cortical cytoskeleton and PAR polarity proteins. Through mechanisms tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d115d7197c20fcbdebe9c533a90d3685
https://doi.org/10.1242/dev.027060
https://doi.org/10.1242/dev.027060
Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint
Autor:
Sue Biggins, Nitobe London
The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by preventing cell division when chromosomes are not correctly attached to the spindle. Checkpoint activation depends on the hierarchical recruitment of checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028147a4167e0b88bf73863a8f5f70cd
https://europepmc.org/articles/PMC3909788/
https://europepmc.org/articles/PMC3909788/
