Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Nitinchandra D. Patel"'
Autor:
Suttipol Radomkit, Daniel R. Fandrick, Stefan Braith, Chris H. Senanayake, Arindom Chatterjee, Keith R. Fandrick, Carl A. Busacca, Nitinchandra D. Patel
Publikováno v:
The Journal of Organic Chemistry. 86:4877-4882
A mild and nonreversible tert-butylation of alcohols and phenols can be achieved in high yields using the noncoordinating acid–base catalyst [bis(trifluoromethane)sulfonimide and 2,6-lutidine] with...
Autor:
Heewon Lee, Nelu Grinberg, Nitinchandra D. Patel, Andrew Ye, Azad Hossain, Carl A. Busacca, Jon C. Lorenz, Chris H. Senanayake, Anjan Saha, Denis Byrne, Nizar Haddad, Suresh R. Kapadia, Xudong Wei, Nathan K. Yee, Philomen DeCroos, Bikshandarkoil A. Narayanan, Max Sarvestani, Scott Pennino
Publikováno v:
The Journal of Organic Chemistry. 85:8339-8351
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive SNAr reaction of 4-quinolinyl sulfones with a range of structurally diversified 1°, 2°, and 3° alcohols with a wide substrate scope and
Autor:
Zhulin Tan, Nitinchandra D. Patel, Harald Engelhardt, Mark Petronczki, Georg Egger, Elisabeth Grondal, Lyne Lamarre, Joyce C. Leung, Bernadette Sharps, Nizar Haddad, Anke Baum, Andreas Bergner, Andreas Schrenk, Renate Schnitzer, Eugene Chong, Tobias Wunberg, Moriz Mayer, Thomas Gerstberger, Dietrich Böse, Andreas Zoephel, Darryl B. McConnell, Christian Engelhardt, Monika Kriz, Nina C. Gonnella, Mariusz Krawiec, Heinz Stadtmüller, Peter Ettmayer, Jonathan T. Reeves, Julian E. Fuchs, Barbara Hopfgartner, Dirk Scharn, Andreas Grimm, Biljana Peric Simov, Flavio Solca, Gerd Bader, Sandra Döbel, Roland Kousek
Publikováno v:
Journal of Medicinal Chemistry. 62:10272-10293
The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase inhibitors (TKIs) are accompanied by marked tumor
Autor:
Keith R, Fandrick, Nitinchandra D, Patel, Suttipol, Radomkit, Arindom, Chatterjee, Stefan, Braith, Daniel R, Fandrick, Carl A, Busacca, Chris H, Senanayake
Publikováno v:
The Journal of organic chemistry. 86(6)
A mild and nonreversible
Autor:
Nitinchandra D, Patel, Xudong, Wei, Denis, Byrne, Bikshandarkoil A, Narayanan, Scott, Pennino, Max, Sarvestani, Anjan, Saha, Nizar, Haddad, Suresh, Kapadia, Jon C, Lorenz, Philomen, DeCroos, Andrew, Ye, Heewon, Lee, Nelu, Grinberg, Azad, Hossain, Carl A, Busacca, Nathan K, Yee, Chris H, Senanayake
Publikováno v:
The Journal of organic chemistry. 85(13)
An efficient general methodology for the synthesis of 4-quinolinyl ethers is demonstrated via a highly reactive S
Autor:
Sergei Tcyrulnikov, Joshua D. Sieber, Nitinchandra D. Patel, Kendricks S. Lao, Marisa C. Kozlowski, Soumik Biswas, Chris H. Senanayake, Nelu Grinberg, Krishnaja Duvvuri, Neil K. Garg, B. Frank Gupton, Daniel Rivalti, Jinhua J. Song, Scott Pennino, Bo Qu, Heewon Lee, Donghong A. Gao, Yongda Zhang, Hari P. R. Mangunuru, Nizar Haddad, Bryan J. Simmons, Keith R. Fandrick
Publikováno v:
ACS Catalysis. 8:10190-10209
Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substi
Autor:
Nitinchandra D. Patel, Marisa C. Kozlowski, Osvaldo Gutierrez, Chris H. Senanayake, Carl A. Busacca, Keith R. Fandrick, C. Avery Sader, Daniel R. Fandrick, Yike Zou
Publikováno v:
Organic Letters
A copper-catalyzed site-selective propargylation/allenylation reaction toward carbonyl compounds has been mechanistically investigated using a computational approach. Different reaction pathways and catalytic cycles were investigated. Control of the
Autor:
Zhidong Chen, Carl A. Busacca, Shengli Ma, Xingzhong Zeng, Peter Allen Nemoto, Paige E. Mahaney, Jason A. Mulder, Chris H. Senanayake, Jun Wang, Nitinchandra D. Patel, Zhibin Li, Todd Bosanac, Daniel R. Fandrick, Jean-Nicolas Desrosiers, Heewon Lee, Sonia Rodriguez, Jon C. Lorenz, Nathan K. Yee, Joe Gao, Nelu Grinberg, Hidenori Takahashi, Alessandra Bartolozzi, Jinhua J. Song, Keith R. Fandrick
Publikováno v:
Organic Process Research & Development. 21:1427-1434
A practical and efficient synthesis of the FLAP inhibitor 1 was developed addressing multiple scale-up and safety concerns posed by the established synthesis and utilized a resolution strategy (replacing supercritical fluid chromatography (SFC) separ
Autor:
Daniel Rivalti, Carl A. Busacca, Bo Qu, Arindom Chatterjee, Nathan K. Yee, Nitinchandra D. Patel, Nizar Haddad, Chris H. Senanayake, Joshua D. Sieber, Frederic G. Buono, Sonia Rodriguez, Jean-Nicolas Desrosiers, Stefan Braith, Keith R. Fandrick, Heewon Lee
Publikováno v:
Asian Journal of Organic Chemistry. 6:1285-1291
Autor:
Heewon Lee, Nelu Grinberg, Nizar Haddad, Chris H. Senanayake, Nathan K. Yee, Joshua D. Sieber, Dmitry Kurouski, Nitinchandra D. Patel, Keith R. Fandrick, Jinhua J. Song, Bo Qu, Jean-Nicolas Desrosiers, Sonia Rodriguez, Hari P. R. Mangunuru
Publikováno v:
Advanced Synthesis & Catalysis. 358:3522-3527
Through a computer-guided approach, new series of monophosphine ligands were designed and developed for asymmetric Suzuki–Miyaura couplings of challenging heterocyclic substrates. Computer modeling pointed to a tunable, yet unexplored quadrant in B